MCS-INTEST

Mesenchymal Cells of the Lamina Propria in Intestinal Epithelial and Immunological Homeostasis

 Coordinatore BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

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 Nazionalità Coordinatore Greece [EL]
 Totale costo 2˙590˙000 €
 EC contributo 2˙590˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-07-01   -   2019-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

 Organization address address: Al. Fleming Street 34
city: VARI-ATHENS
postcode: 16672

contact info
Titolo: Dr.
Nome: Piyi
Cognome: Papadaki
Email: send email
Telefono: +30 210 9656310
Fax: +30 210 9653934

EL (VARI-ATHENS) hostInstitution 2˙590˙000.00
2    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

 Organization address address: Al. Fleming Street 34
city: VARI-ATHENS
postcode: 16672

contact info
Titolo: Prof.
Nome: Georgios
Cognome: Kollias
Email: send email
Telefono: +30 210 9656507
Fax: +30 210 9656563

EL (VARI-ATHENS) hostInstitution 2˙590˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    homeostasis    mesenchymal    immunological    physiological    inflammatory    mc    chronic    epithelial    mcs    pathophysiology    signals    innate    functions    intestinal    disease   

 Obiettivo del progetto (Objective)

'Mesenchymal cells (MCs) of the intestinal lamina propria refer to a variety of cell types, most commonly intestinal myofibroblasts, fibroblasts, pericytes, and mesenchymal stromal cells, which show many similarities in terms of origin, function and molecular markers. Understanding the physiological significance of MCs in epithelial and immunological homeostasis and the pathophysiology of chronic intestinal inflammatory and neoplastic disease remains a great challenge. In this proposal, we put forward the challenging hypothesis that, especially during acute or chronic inflammatory and tumorigenic conditions, MCs play important physiological roles in intestinal homeostasis regulating key processes such as epithelial damage, regeneration and tumorigenesis, intestinal inflammation and lymphoid tissue formation. We further posit that a unifying principle underlying such functions would be the innate character of MCs, which we hypothesize are capable of directly sensing and metabolizing innate signals from microbiota or cytokines in order to exert homeostatic epithelial and immunological regulatory functions in the intestine. We will be using genetic approaches to target innate pathways in MCs and state of the art phenotyping to discover the physiologically important signals orchestrating intestinal homeostasis in various animal models of intestinal pathophysiology. We will also study MC lineage relations and plasticity during disease and develop ways to interfere therapeutically with MC physiology to achieve translational added value for intestinal diseases, as well as for a range of other pathologies sharing similar characteristics.'

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