MODELCELL

Building a Model Cell to Achieve Control of Cellular Organization

Coordinatore	TECHNISCHE UNIVERSITEIT DELFT    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	7˙150˙812 €
EC contributo	7˙150˙812 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-SyG
Funding Scheme	ERC-SyG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-07-01   -   2020-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Astrid Cognome: Haijma Email: send email Telefono: +31 30 2539227	NL (UTRECHT)	beneficiary	3˙559˙640.00
2	TECHNISCHE UNIVERSITEIT DELFT  Organization address address: Stevinweg 1 city: DELFT postcode: 2628 CN contact info Titolo: Mrs. Nome: Jose Cognome: Van Vugt Email: send email Telefono: +31 15 2787413	NL (DELFT)	hostInstitution	3˙591˙172.00
3	TECHNISCHE UNIVERSITEIT DELFT  Organization address address: Stevinweg 1 city: DELFT postcode: 2628 CN contact info Titolo: Prof. Nome: Aletta Maria Cognome: Dogterom Email: send email Telefono: 31152785937 Fax: 31152781202	NL (DELFT)	hostInstitution	3˙591˙172.00

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 Obiettivo del progetto (Objective)

A hallmark of profound understanding of the organization of a living cell is the ability to reconstitute essential cellular functionalities from minimal components. To achieve this breakthrough a concerted effort of cell biology, biochemistry and biophysics is required. Our project brings together this expertise to reconstitute the cell’s ability to control the organization of cytoskeletal networks in an artificial ‘Model’ Cell.

To achieve a mechanistic understanding of how cell organization is regulated, we will develop methods to manipulate cytoskeletal interactions in space and time and study the effects of such manipulation on functional cytoskeletal organization in the confinement of both artificial systems and cells. We will focus on regulatory interactions at dynamic microtubule plus ends, which play an essential role in cell division, polarization, and migration. Using a combination of in vitro, in vivo, and theoretical approaches, we aim at the following goals: 1. Achieve a molecular scale understanding of cooperative and competitive relationships between regulators at microtubule ends, and their effect on microtubule dynamics, microtubule behavior at the cell boundary, and interactions with actin filaments. 2. Generate a quantitative understanding of symmetric and polarized positioning of the microtubule cytoskeleton by microtubule-cell boundary interactions during cell division and cell migration. 3. Obtain a mechanistic view of microtubule-actin co-organization driven by regulatory effects at microtubule ends, with and without the additional contribution of microtubule-cell boundary interactions, and apply this knowledge to manipulate cell polarization and migration.

Synergy between our complementary expertise, tools, infrastructure and local collaboration networks is key to achieving these goals. Our groups are located within short travel distance from each other, allowing the coupling of infrastructure and resources on a daily basis.