MUSTEMERR

Regulation of muscle stem cells by ERRgamma

 Coordinatore UNIVERSITY OF HULL 

 Organization address address: COTTINGHAM ROAD
city: HULL
postcode: HU6 7RX

contact info
Titolo: Mr.
Nome: Phil
Cognome: Macdonald
Email: send email
Telefono: 441482000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-09-01   -   2018-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF HULL

 Organization address address: COTTINGHAM ROAD
city: HULL
postcode: HU6 7RX

contact info
Titolo: Mr.
Nome: Phil
Cognome: Macdonald
Email: send email
Telefono: 441482000000

UK (HULL) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

repair    myofibre    err    muscle    satellite    regeneration    gamma    cells    hypothesis    receptors    injury    skeletal    recruitment    determine    cell   

 Obiettivo del progetto (Objective)

'Skeletal muscle is a highly plastic tissue capable of spontaneous repair in response to injury via the recruitment of muscle stem cells called the satellite cells. These cells are localised within the myofibre basal lamina and are activated upon muscle damage, they proliferate and differentiate to replace the damaged muscle. Satellite cells are the key rate-limiting step for successful repair and the transcriptional cues that emanate from the skeletal muscle to activate regeneration are unclear. Thus, discovery of key molecules that regulate satellite cell activation will accelerate the ability to stimulate muscle repair. Estrogen related receptors (ERR isoforms α, β and γ) are a sub-family of orphan nuclear hormone receptors that have been identified as major regulators of cellular and mitochondrial metabolism. Skeletal muscle-specific overexpression of ERRγ has been shown to drive metabolic and angiogenic muscle reprogramming in both health and disease. This project will test the hypothesis that targeting ERRγ in skeletal muscle will improve the myofibre regenerative capacity via satellite cell recruitment and secretion of growth factors. Identification of the underlying mechanisms will provide new knowledge that can be exploited to develop new therapeutic avenues for promoting satellite cell recruitment and myofibre regeneration in terms of injury or degenerative conditions like ageing and muscle wasting disorders. The hypothesis will be tested by addressing the following specific aims: 1) To establish the satellite cell proliferation and differentiation profiles in ERRγ transgenic muscles at baseline and in response to acute eccentric exercise. 2) To investigate the effect of ERRγ on satellite cell recruitment in response to muscle injury. 3) To determine the interplay between muscular revascularisation and reparative myogenesis by ERRγ. 4) To determine whether an AAV-mediated ERRγ delivery increases satellite cell recruitment and improves muscle integrity.'

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