DEPRONIL

Development of molecular probes for the non-invasive detection of liver fibrosis

 Coordinatore RIJKSUNIVERSITEIT GRONINGEN 

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Dr.
Nome: Simon K.
Cognome: Kuipers
Email: send email
Telefono: +31 (0)50 3635282
Fax: +31 (0)50 3634847

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 229˙076 €
 EC contributo 229˙076 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-1-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-07-01   -   2012-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Dr.
Nome: Simon K.
Cognome: Kuipers
Email: send email
Telefono: +31 (0)50 3635282
Fax: +31 (0)50 3634847

NL (GRONINGEN) coordinator 0.00
2    "Beth Isreal Deaconess Medical Center, Harvard Medical School"

 Organization address address: Brookline Avenue 330
city: "Boston, MA"
postcode: 2115

contact info
Titolo: Prof.
Nome: Detlef
Cognome: Schuppan
Email: send email
Telefono: 617-667-2371
Fax: 617-667-2767

US ("Boston, MA") participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

liver    fibrosis    imaging    detection    probes    fibrogenesis    fibrolysis    disease    body    markers    quantification   

 Obiettivo del progetto (Objective)

'Liver fibrosis is a progressive and fatal disease characterized by the accumulation of excessive amounts of scar tissue in response to chronic liver injury. The disease proceeds asymptomatically, until clinical signs of liver failure occur only in a very late stage of the disease. Early diagnosis would offer better treatment options. However, early detection and quantification of fibrosis, as well as determining the rate of fibrosis progression (fibrogenesis) or reversal (fibrolysis) still depends on rudimentary and inaccurate methods. This proposal focuses on the development of a new method for the quantification of liver fibrosis and its dynamics, based on the design of molecular probes that can selectively pinpoint these processes in non-invasive imaging studies. To this end, novel disease markers of fibrosis, fibrogenesis and fibrolysis will be identified using state-of-the-art proteomic techniques, simultaneously taking into account that these markers will have to be easily accessible for intravenously-injected ligands in vivo. Based on the identified markers, binding probes will be synthesized and evaluated for their detection capabilities in fibrosis models. To this end, whole body imaging studies are used, combined with novel pharmacokinetic-modeling approaches, in which body distribution, cellular uptake and excretion of the new probes are correlated to disease parameters.'

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