GEFOS
GENETIC FACTORS FOR OSTEOPOROSIS
| Coordinatore | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Sito del progetto | http://www.gefos.org/ |
| Totale costo | 4˙648˙972 € |
| EC contributo | 2˙998˙650 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-03-01 - 2012-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | coordinator | 0.00 |
| 2 |
CALIFORNIA PACIFIC MEDICAL CENTER RESEACH INSTITUTE
Organization address
address: California street contact info |
US (SAN FRANSISCO) | participant | 0.00 |
| 3 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 0.00 |
| 4 |
HEBREW SENIOR LIFE
Organization address
address: Centre st contact info |
US ("BOSTON, MA") | participant | 0.00 |
| 5 |
ISLENSK ERFDAGREINING EHF
Organization address
address: Sturlugata 8 contact info |
IS (REYKJAVIK) | participant | 0.00 |
| 6 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 0.00 |
| 7 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 0.00 |
| 8 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 0.00 |
| 9 |
THE UNIVERSITY OF QUEENSLAND
Organization address
address: ST LUCIA contact info |
AU (BRISBANE) | participant | 0.00 |
| 10 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 0.00 |
| 11 |
UNIVERSITY OF IOANNINA
Organization address
address: "LEOFOROS STAVROS S NIARCHOS, PANEPISTIMIOUPOLI IOANNINON" contact info |
EL (IOANNINA) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Osteoporosis is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe and industrialised countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this, and genetic susceptibility alleles are the most promising risk factors in this respect. Large-scale prospective meta-analysis of individual gene polymorphisms in the EU-funded GENOMOS consortium was shown successful in identifying the expected subtle effects of gene polymorphisms which predispose to osteoporosis. The recent development of powerful genome-wide genotyping technology now allows to identify -hypothesis free- strong and common genetic risk factors for complex diseases by Genome Wide Association (GWA) analysis. The AIM of the proposal is to identify osteoporosis susceptibility alleles by meta-analysis of GWA data obtained from a large collection of osteoporosis genetics cohorts in Europe and outside (n=46.000). Prospective meta-analysis of GENOMOS, a large consortium of genetic studies on osteoporosis (n=80.000), is used to assess generalizability of genetic effects and develop sufficient power to quantify even small, but clinically important risks. The improvement in clinical risk-assessment for osteoporosis by adding the diagnostic panel of osteoporosis risk-alleles identified in this project, will be quantified in prospective studies including genetic and classical risk factors.'
Introduzione (Teaser)
A large-scale research effort has for the first time identified genetic markers that can be used to predict susceptibility to osteoporosis. This age-related disease affects millions of older individuals every year, and places a huge economic burden on the EU.
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