MRNA LOCALIZATION

Resolving the molecular mechanisms responsible for the localization of mRNA through active transport

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Linda
Cognome: Polik
Email: send email
Telefono: -291632
Fax: -291622

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 169˙957 €
 EC contributo 169˙957 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-2-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-06-09   -   2010-06-08

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Linda
Cognome: Polik
Email: send email
Telefono: -291632
Fax: -291622

UK (OXFORD) coordinator 0.00

Mappa


 Word cloud

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transacting    molecular    active    anchoring    particles    gurken    mechanisms    bicoid    composition    localization    rnas    rna    transport    hypothesis    complexes   

 Obiettivo del progetto (Objective)

'I intend to further characterize the molecular mechanisms responsible for the localization of mRNA (RNA) through active transport by motors on microtubule tracks. My specific aims are: 1) Elucidating the dynamics of active RNA transport. I will investigate how unique RNAs arrive at discrete cellular destinations using the same molecular motor and the hypothesis that RNAs travel on distinct populations of microtubules. To study bicoid and gurken RNA transport particles I will use OMX for very rapid and highly sensitive image acquisition in three dimensions of several channels simultaneously. 2) Distinguishing the mechanisms of RNA maintenance and anchoring. I will test the hypothesis that the ultrastructure and composition of RNA transport and anchoring complexes changes through the course of development using cryo-immuo EM. I will compare the transport particles of different RNAs (i.e. bicoid, gurken, nanos) and co-visualize these with key transacting factors such as Stuafen, Exuperentia and Squid. 3) Determining the mechanism of multiple localization events for a single RNA. I will address the hypothesis that the confirmation and composition of transport and anchoring complexes stage at different steps and times during development. Using live cell imaging of photoactivatable components, I will characterize changes in residency time of RNAs and their transacting factors within transport and anchoring structures'

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