CANCERSTEM

Stem cells in epithelial cancer initiation and growth

 Coordinatore UNIVERSITE LIBRE DE BRUXELLES 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 1˙600˙000 €
 EC contributo 1˙600˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-07-01   -   2013-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Dr.
Nome: Cédric
Cognome: Blanpain
Email: send email
Telefono: +32-2-555 4175
Fax: +32-2-555 4655

BE (BRUXELLES) hostInstitution 0.00
2    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Dr.
Nome: Christine
Cognome: Courillon
Email: send email
Telefono: +32 2 650 67 18
Fax: 3226502321

BE (BRUXELLES) hostInstitution 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

tumor    stem    self    tools    mutations    initial    scs    cancer    determine    oncogenic    epithelial    specifically    normal    cells    cancers    arise    sc    adult    contain    skin   

 Obiettivo del progetto (Objective)

'Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes. For most cancers, the target cells of oncogenic mutations are unknown. Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation. Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumor upon transplantation. However, whether the initial oncogenic mutations arise in normal stem cells or in more differentiated cells that re-acquire stem cell-like properties remains to be determined. The demonstration that SCs are the target cells of the initial transforming events and that cancers contain cells with SC characteristics await the development of tools allowing for the isolation and characterization of normal adult SCs. In most epithelia from which cancers naturally arise, such tools are not yet available. We have recently developed novel methods to specifically mark and isolate multipotent epidermal slow-cycling SCs, making it now possible to determine the role of SC during epithelial cancer formation. In this project, we will use mice epidermis as a model to define the role of SC in epithelial cancer initiation and growth. Specifically, we will determine whether epithelial SCs are the initial target cells of oncogenic mutations during skin cancer formation, whether oncogenic mutations lead preferentially to skin cancer when they arise in SC rather than in more committed cells and whether cancer stem cells contribute to epithelial tumor growth and relapse after therapy.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

LABCHIP_MULTIPLEX (2010)

Simultaneous Detection of Multiple DNA and Protein Targets on Paramagnetic Beads Packed in Microfluidic Channels using Quantum Dots as Tracers

Read More  

GTMT (2011)

Group Theory and Model Theory

Read More  

X-MUSIC (2014)

XUV/X-ray Multidimensional Spectroscopy of Fundamental Electron Dynamics and Impulsive Control of X-ray Light

Read More