SELECT-AND-ACT

"The role of striatum in selection of behaviour and motor learning - neuronal code, microcircuits and modelling"

 Coordinatore KAROLINSKA INSTITUTET 

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Prof.
Nome: Sten
Cognome: Grillner
Email: send email
Telefono: +46 8 52486900
Fax: +46 8 349544

 Nazionalità Coordinatore Sweden [SE]
 Sito del progetto http://www.neuro.ki.se/selact/site/
 Totale costo 3˙253˙587 €
 EC contributo 2˙495˙781 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-08-01   -   2012-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Prof.
Nome: Sten
Cognome: Grillner
Email: send email
Telefono: +46 8 52486900
Fax: +46 8 349544

SE (STOCKHOLM) coordinator 0.00
2    KUNGLIGA TEKNISKA HOEGSKOLAN

 Organization address address: Valhallavaegen 79
city: STOCKHOLM
postcode: 10044

contact info
Titolo: Ms.
Nome: Tina
Cognome: Billing-Ericson
Email: send email
Telefono: +46 8 7907323
Fax: +46 8 7900930

SE (STOCKHOLM) participant 0.00
3    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Ann-Marie
Cognome: Coriat
Email: send email
Telefono: +44 (0)1235 841290
Fax: +44 (0)1235 841451

UK (SWINDON) participant 0.00
4    THE HEBREW UNIVERSITY OF JERUSALEM.

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Dr.
Nome: Eran
Cognome: Vardi
Email: send email
Telefono: +972 2 6586676
Fax: +972 2 6513205

IL (JERUSALEM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

striatum    modulatory    cholinergic    performed    organisation    thalamic    actions    cognitive    select    underlying    motor    studied    neuronal    projections    microcircuitry    determining    histaminergic    inputs    cortical    cortex    patch    signals    symptoms    microcircuit    dysfunction    critical    computer    separate    microcircuits    plasticity    neurons    dopamine    synaptic    ht    ganglia    input    takes    connections    brain    experimental    dopaminergic    act    striatal    interaction    function    pallidal    relation    disease    basal    instant    filter    thalamus   

 Obiettivo del progetto (Objective)

'The input layer of the basal ganglia, the striatum, plays a critical role in the control of motor behaviour and cognitive function. It serves as a filter for cortical and thalamic signals and takes part in determining which actions should be performed at a given instant. Our goal is to define the cellular and network organisation underlying decision-making by analysing the microcircuitry of subpopulations of neurons in striatum (interneurons and projection neurons) concerned with the control of different patterns of behaviour, and their input from cortex (pallium), thalamus and the modulatory inputs from dopaminergic, histaminergic and 5-HT neurons. The microcircuitry will be studied in slices of striatum with patch electrode recordings from three or more identified subtypes of neurons at the same time, while synaptic and membrane properties are investigated and also the synaptic response to the different input systems. Specific synaptic connections of the recorded neurons will be identified by electron microscopy and quantitative aspects of the connections of the different classes of neurons will be defined. Striatal neuronal activity will also be studied in behaving animals with multiunit neuronal recording in relation to defined motor behaviours utilizing several vertebrate model systems (lamprey, rodent and primate). The primary focus will be on striato-pallidal projections indirectly controlling motor programs at the brainstem/spinal cord level, rather than via the thalamo-cortical forebrain projections since these projections cannot as easily be interpreted. Neuronal function and synaptic interaction at the microcircuit level will be subjected to a detailed computer modelling based directly on the outcome of the experimental analyses. Plasticity underlying motor learning/synaptic plasticity, particularly in relation to the dopaminergic, 5-HT and histaminergic inputs will also be characterized.'

Introduzione (Teaser)

Many motor, psychiatric and neurological conditions involve dysfunction of the basal ganglia. Understanding the normal function of the striatum is therefore a prerequisite for determining the underlying pathology in a diseased state.

Descrizione progetto (Article)

The debilitating motor symptoms underlying Parkinson's disease (PD) are due to a deficiency of dopamine and other neuromodulators causing dysfunction of striatal microcircuits. It is therefore of critical importance to understand how these circuits function in order to develop new therapeutic interventions.

The striatum is an internal structure of the brain responsible for regulating motor behaviour and cognitive function. It receives input from many brain areas but sends output only to other components of the basal ganglia, essentially serving as a filter for cortical and thalamic signals. As a result, it takes part in determining which actions should be performed at a given instant.

The overall objective of the EU-funded Select-AND-ACT project was to delineate the intrinsic function of the basal ganglia located in the striatum. This would unveil the neural mechanisms involved in action determination.

To achieve this, partners analysed multicellular microcircuits of striatal sub-populations combining modeling and functional monitoring of neuronal activity during actual behaviour. Using fish, rats and primates as experimental models, they investigated input from the cortex and the thalamus, and modulatory inputs from dopaminergic, histaminergic and cholinergic (5-HT) neurons.

Patch electrodes were used to record the activity of neurons, and also monitor the synaptic response to different input systems. Results suggested that histamine release entrained striatal function, and cholinergic modulation had an inhibitory effect on GABAergic synapses.

Moreover, it was seen that the separate compartments within the striatum (referred to as striosomes and matriosomes) received input from separate types of cortex, but they affected the dopamine system and pallidal neurons separately. Detailed computer modelling was also developed to study neuronal function and synaptic interaction at the microcircuit level.

From a scientific perspective, the Select-AND-ACT consortium showed that the striatum is an evolutionary conserved region of the brain with the basal ganglia maintaining a specific organisation pattern throughout evolution. The project findings provided important knowledge on striatal function at the microcircuit level, linked to behaviour, and are expected to contribute to an understanding of basal ganglia disease symptoms and reasons for dysfunction.

Altri progetti dello stesso programma (FP7-HEALTH)

ADVANCE_HTA (2013)

Advancing and strengthening the methodological tools and practices relating to the application and implementation of Health Technology Assessment (HTA)

Read More  

NANOBIO4TRANS (2012)

A new nanotechnology-based paradigm for engineering vascularised liver tissue for transplantation

Read More  

SPIDIA (2008)

Standardisation and improvement of generic pre-analytical tools and procedures for in vitro diagnostics

Read More