TRANSSIADRUG

Chagas' disease - Inhibitor discovery and optimization for Trypanosoma cruzi trans-sialidase

 Coordinatore VIB 

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Wim
Cognome: Goemaere
Email: send email
Telefono: +329244 66 11
Fax: +329244 66 99

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 157˙288 €
 EC contributo 157˙288 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-2-1-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2009-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Wim
Cognome: Goemaere
Email: send email
Telefono: +329244 66 11
Fax: +329244 66 99

BE (ZWIJNAARDE - GENT) coordinator 0.00

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enzyme    assay    ligands   

 Obiettivo del progetto (Objective)

'This proposal focus on finding new potential lead compounds to inhibit the trans-sialidase of Trypanosoma cruzi, as a step towards finding a drug against Chagas’ disease. A new high through-put enzyme assay will be used to scan a large library of small molecules and in combination with in silico pharmacophoric modelling this is expected to provide new types of scaffolds as well as identifying important functionalities in the ligand. Based on the obtained information a set of ligands will be designed. These ligands will be synthesised and further evaluated through the enzyme assay, kinetic and thermodynamical studies as well as structural studies. In an iterative optimization, these tools will be combined to obtain future generations of inhibitory ligands.'

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