MECHPROCMOLS

A Synthetic Molecule that can Walk down a Track!

 Coordinatore THE UNIVERSITY OF EDINBURGH 

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 650 9023

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 178˙874 €
 EC contributo 178˙874 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-2-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2010-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 650 9023

UK (EDINBURGH) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

track    processive    along    walker    stimuli    energy    synthetic    motion    synthesis    molecular   

 Obiettivo del progetto (Objective)

'Nature’s conversion of chemical energy into directed molecular motion has inspired the design of many synthetic molecular architectures aimed at performing function on the molecular scale. Synthesis of small molecule analogues of these much more intricate biological systems may allow man to model the efficiency, and possibly develop processes that parallel the effectiveness of energy transfer in natural systems. The proposed research outlines the synthesis and operation of a synthetic “walker” and “track” conjugate, which is designed to result in synthetic molecular processive motion induced by appropriate stimuli, much like that of Kinesin and Dynein which are linear motor proteins (driven by ATP hydrolysis) that engage in processive motion intracellularly . Organic synthesis of the components and self-assembly of the conjugates by transition metal coordination chemistry will gain us access to the desired synthetic targets. Invoking stimuli responsive molecular movement of the “molecular walker” component along the “molecular track” component will be achieved by exploiting the ligand-coordinate bond with various acid/base and oxidation/reduction states, while progress of the “walker” moving along the “track” will be monitored by NMR, MS, UV-Vis, and FRET.'

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