SUPMED

"Supramolecular Medicine: Modular, Double Dynamic and Orthogonal Functionalization of Supramolecular Biomaterials"

Coordinatore	TECHNISCHE UNIVERSITEIT EINDHOVEN    more  Organization address address: DEN DOLECH 2 city: EINDHOVEN postcode: 5612 AZ contact info Titolo: Mr. Nome: J.M.R. Cognome: Debeij Email: send email Telefono: 0031 40 247 5132 Fax: 0031 40 247 2206
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	0 €
EC contributo	168˙291 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2011-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN  Organization address address: DEN DOLECH 2 city: EINDHOVEN postcode: 5612 AZ contact info Titolo: Mr. Nome: J.M.R. Cognome: Debeij Email: send email Telefono: 0031 40 247 5132 Fax: 0031 40 247 2206	NL (EINDHOVEN)	coordinator	168˙291.38

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 Obiettivo del progetto (Objective)

'The main objective of this project is to create a new generation of smart biomaterials with great potential for tissue engineering and controlled drug delivery. Supramolecular polymers based on quadruple hydrogen bonding ureido-pyrimidinone (UPy) moieties (developed by the host group of Prof. Dr. E. W. Meijer in Eindhoven University of Technology, the Netherlands) will be employed as a basic scaffold. To fulfill the biomaterials trinity, namely tuneable mechanical properties, biodegradability and bioactivity, we propose a unique approach to functionalize the biomaterial scaffold in order to generate biomedical activity. The combination of dynamic covalent chemistry (developed by the group of Prof. Dr. Jean-Marie Lehn in Louis Pasteur University, France where the applicant comes from) and non-covalent UPy-UPy hydrogen bonding allows for a modular (self-assembly) and orthogonal (self-sorting) approach to control cellular behaviour and activity both in vitro and in vivo. Due to their dynamic characters on both non-covalent and reversible covalent levels, they can be considered as constitutional double dynamic biomaterials, capable of response to different external stimuli (pH, temperature etc.), thus behaving as adaptive biomaterials. The results that will emerge from the current proposal are of particular interest for the fields of regenerative medicine and controlled drug delivery, which have a remarkable impact in human health care. This project will initiate the first cooperation between the host group and the group the applicant comes from, to tackle a major challenge for chemical biologists. Hence, it will contribute to European research and transfer of knowledge.'