WBAWBA

Polymer conjugation of peptides/salmon calcitonin for increased efficacy

 Coordinatore THE UNIVERSITY OF WARWICK 

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Dr.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: +44 24 7652 3716
Fax: +44 24 7652 4991

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 0 €
 EC contributo 182˙484 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-09-14   -   2011-09-13

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Dr.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: +44 24 7652 3716
Fax: +44 24 7652 4991

UK (COVENTRY) coordinator 182˙484.78

Mappa


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conjugation    peptide    polymers    living    synthesis    radical    lrp    conjugates    polymerization   

 Obiettivo del progetto (Objective)

'This project is concerned with the development of a new peptide conjugation strategy which has the potential to overcome the limitations of the, commercially successful, conventional pegylation with linear polymers. In addition it will explore the application of single electron transfer living radical polymerization (SET-LRP) for this purpose. Project Objectives 1. Synthesis and characterization of α-functional comb polymers by living radical polymerization 2. Hydrolysis studies of polymers and polymer conjugates 3. Evaluation of SET-LRP for synthesis of conjugates 4. Conjugation of polymers to salmon calcitonin 5. Purification and isolation of conjugates 6. Gastric peptide stability testing 7. Use of tryptic digestion to confirm conjugation site(s) 8. In vitro cAMP bio assays for sCT activity'

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