STEMRB

Role of siRNA-mediated DNA methylation in the root stem cell niche

Coordinatore	UNIVERSITEIT UTRECHT    more  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Herminia Cognome: Erasmo Email: send email Telefono: 31-30-2532614 Fax: 31-30-2531645
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	0 €
EC contributo	169˙425 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2011-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Herminia Cognome: Erasmo Email: send email Telefono: 31-30-2532614 Fax: 31-30-2531645	NL (UTRECHT)	coordinator	169˙425.40

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 Obiettivo del progetto (Objective)

'Stem cells are undifferentiated cells that can give rise to different cell types in multicellular organisms. Plant and animal stem cells are usually not specified by the same subset of genes, even though the niche organizations are very similar. The Retinoblastoma (Rb) protein and its plant homologue RETINOBLASTOMA-RELATED (RBR) in stem cell identity however constitutes a possible common pathway in both kingdoms (1). We want to further explore possible similarities in stem cell control, so we focused on RBR interactors in order to find conserved mechanisms. RBR shares two main protein-protein interaction domains with its animal homologs; one interacts with the transcription factor E2F and the other with LxCxE containing motif proteins (such as viral proteins and histone deacetylases). Interestingly, we have found that two proteins implicated in siRNA mediated silencing contain LxCxE domains, and both mutants show a root phenotype. Our aim is to characterize the role of siRNA-mediated silencing in the root meristem stem cells, and to identify the role of RBR in this pathway. It has been found that small inhibitory RNAs control the shoot apical meristem and flowering transition as well as root cap cell formation and lateral root formation (2,3). We will try to identify the role that siRNAs have in stem cell identity.'