BIOPYRR
New Methodology for the Synthesis of Bioactive Pyrrolidines and Pyrrolidinones
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 130˙430 € |
| EC contributo | 130˙430 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-03-01 - 2011-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | coordinator | 130˙430.60 |
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Obiettivo del progetto (Objective)
'The development of new and efficient methodology for the synthesis of privileged structures of biological importance is an ever important goal for organic chemists. Natural products continue to provide a source of such important chemical entities for the treatment of human diseases. In particular the pyrrolidine and pyrrolidinone motif are biologically privileged structures which are present in over 9000 natural products, many of which possess important biological activity. The aim of this proposal is to develop a range of new transition metal mediated and transition metal catalysed synthetic methodologies for the efficient synthesis of pyrrolidines and pyrrolidinones which will be applied to the total synthesis of a biologically important natural product which contains a lactone-pyrrolidinone as its core heterocyclic motif. The developed synthetic methodology will also be applicable to the synthesis of a wide range of biologically active natural product targets.'