PORPH_IMP_SHG

Porphyrin-Based Dyes for Imaging Membrane Potential via Second Harmonic Generation

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Linda
Cognome: Pialek
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 172˙740 €
 EC contributo 172˙740 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-05-01   -   2012-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Linda
Cognome: Pialek
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

UK (OXFORD) coordinator 172˙740.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biological    area    expertise    optical    living    membrane    synthesis    porphyrins    group    chemistry    cells    porphyrin    dyes    oxford    shg    anderson   

 Obiettivo del progetto (Objective)

'Based on recently published work from Anderson’s group in Oxford, this proposal aims to develop a new technique for optical imaging of membrane potential in living cells using second-harmonic generation (SHG) microscopy with porphyrin-based dyes. This technology should enable the function of neurons, and other excitable cells, to be monitored in real time, with high spatial resolution, in their native networks. The objectives of this project include (1) the synthesis of new porphyrins that bind efficiently to the plasma membranes of cells, exhibit strong voltage-dependent SHG and which avoid photo-damage and phototoxicity, and (2) the demonstration that these dyes can be used to monitor membrane potential in living cells. Prof. Anderson's group in Oxford has pioneered research into porphyrin-based nonlinear optical dyes for many years, and has great expertise in this area. The Department of Chemistry in Oxford has world-class facilities for this research. Ismael López Duarte will soon complete his PhD in the field of phthalocyanine chemistry, but he has no experience in the synthesis of porphyrins, nor of the design and testing of dyes for biological applications. This Fellowship will give him the opportunity to apply his expertise in synthesis to the creation of useful new biological probes. It will provide him with experience in a new and rapidly growing area of research and enable him to broaden his horizons.'

Altri progetti dello stesso programma (FP7-PEOPLE)

ENACASCASYN (2011)

Enantioselective Organocatalytic Reaction Cascades of Substituted Pyrroles and their Application in Complex Alkaloid Natural Product Synthesis

Read More  

PRESTIGE (2014)

PRES Towards International Gain of Excellence

Read More  

2007UWM (2007)

Let’s discover 2007 underwater mysteries

Read More