ATOMICROBIOLOGY

Elucidation of the architecture and dynamics of the bacterial cell wall by an interdisciplinary approach

 Coordinatore THE UNIVERSITY OF SHEFFIELD 

 Organization address address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN

contact info
Titolo: Dr.
Nome: Tracey
Cognome: Swift
Email: send email
Telefono: -1142221403
Fax: -1142221408

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 239˙289 €
 EC contributo 239˙289 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-05-01   -   2012-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD

 Organization address address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN

contact info
Titolo: Dr.
Nome: Tracey
Cognome: Swift
Email: send email
Telefono: -1142221403
Fax: -1142221408

UK (SHEFFIELD) coordinator 239˙289.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

researcher    training    cell    forefront    architecture    bacterial    whilst    bacteria    wall    pg    afm    ovococci    host    interdisciplinary   

 Obiettivo del progetto (Objective)

'The fellowship will provide the researcher with a word class, career defining, interdisciplinary training in bacterial cell architecture and dynamics. The project is at the interface of biology, chemistry and physics, at an extremely timely moment at the forefront of technological developments. Peptidoglycan (PG) is the main component of the bacterial cell wall, crucial for cell shape and viability. PG is unique to bacteria and its importance is illustrated by the incredibly wide use of cell wall antibiotics such as penicillin and vancomycin. PG is a single macromolecule that surrounds the cell and whilst very strong, is also dynamic, allowing cells to growth and divide. Although the basic composition of PG is quite simple, its complex PG architecture has remained elusive. In a truly interdisciplinary approach the host institution has pioneered the application of high-resolution atomic force microscopy (AFM) to the study of PG architecture of the rod shaped bacterium, Bacillus subtilis. The initial work has provided exciting new and unexpected information, overturning previous models. A key question now arises as to how bacteria with different shapes solve their engineering problems of maintaining cell integrity whilst allowing growth? The researcher has a great pedigree in the study of the biochemistry of the PG of the ovococci (which include a number of important human pathogens). The architecture of the PG of the ovococci is currently unknown. Thus the project will be a fantastic synergy between the researcher and the host laboratory, providing cutting edge training, not only in the application of novel AFM techniques, but also in their development. Such a cross disciplinary project will lift the fellow to be at the forefront of research in the field worldwide. This will give him an ideal platform for his reintegration and establishment as a mature and successful scientist on the international stage.'

Altri progetti dello stesso programma (FP7-PEOPLE)

ALBANIAN DIASPORA (2012)

The invention of a diaspora: the case of Arbëresh

Read More  

NEW IRE-1 ACTIVITY (2010)

Insulin/IGF-1 Signaling Regulates Novel Activities of the ER Stress Response Gene ire-1

Read More  

IRGSCIMA (2012)

Integrated Risk Governance via Spatial Complexity Inspired Models and Algorithms

Read More