Functional and regulatory protein networks of chromatin modifying enzymes


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 Nazionalità Coordinatore Cyprus [CY]
 Totale costo 1˙498˙278 €
 EC contributo 1˙498˙278 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091118
 Funding Scheme ERC-SG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2016-06-30


# participant  country  role  EC contrib. [€] 

 Organization address address: KALLIPOLEOS STREET 75
postcode: 1678

contact info
Titolo: Dr.
Nome: Antonis
Cognome: Kirmizis
Email: send email
Telefono: +357 22 892678
Fax: +357 22 892881

CY (NICOSIA) hostInstitution 1˙498˙278.80

 Organization address address: KALLIPOLEOS STREET 75
postcode: 1678

contact info
Titolo: Ms.
Nome: Xenia
Cognome: Constantinou
Email: send email
Telefono: +357 22 894297
Fax: +357 22 894472

CY (NICOSIA) hostInstitution 1˙498˙278.80


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

regulatory    human    protein    networks    enzymes    biological    modifiers    arginine    modifying    conserved    biochemical    cancer    mechanisms    expression    yeast    cellular    chromatin    genomic    prmts    circuits    pathways    linked   

 Obiettivo del progetto (Objective)

'Proper and controlled expression of genes is essential for normal cell growth. Chromatin modifying enzymes play a fundamental role in the control of gene expression and their deregulation is often linked to cancer. In recent years chromatin modifiers have been considered key targets for cancer therapy and this demands a full understanding of their biological functions. Previous biochemical and structural studies have focused on the identification of chromatin modifying enzymes and characterization of their substrate specificities and catalytic mechanisms. However, a comprehensive view of the biological processes, signaling pathways and regulatory circuits in which these enzymes participate is missing. Protein arginine methyltransferases (PRMTs), which methylate histones and are evolutionarily conserved from yeast to human, constitute an example of chromatin modifying enzymes whose functional and regulatory networks remain unexplored. I propose to use complementary state-of-the-art genomic and proteomic approaches in order to identify the protein networks and cellular pathways that are linked to PRMTs. In parallel, I will identify novel regulatory circuits and define the molecular mechanisms that control methylation of specific histone arginine residues. I will utilize the yeast S. cerevisiae as a model organism because it allows genetic, biochemical and genomic approaches to be combined. Most importantly, many of the pathways and mechanisms in yeast are highly conserved and therefore, the findings from this study will be pertinent to human and other eukaryotic organisms. Establishing a global cellular wiring diagram of PRMTs will serve as a paradigm for other chromatin modifiers and is imperative for assessing the efficacy of these enzymes as therapeutic targets.'

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