CHROMATINMODWEB

Functional and regulatory protein networks of chromatin modifying enzymes

Coordinatore	UNIVERSITY OF CYPRUS    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Cyprus [CY]
Totale costo	1˙498˙278 €
EC contributo	1˙498˙278 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2016-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF CYPRUS  Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 contact info Titolo: Dr. Nome: Antonis Cognome: Kirmizis Email: send email Telefono: +357 22 892678 Fax: +357 22 892881	CY (NICOSIA)	hostInstitution	1˙498˙278.80
2	UNIVERSITY OF CYPRUS  Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 contact info Titolo: Ms. Nome: Xenia Cognome: Constantinou Email: send email Telefono: +357 22 894297 Fax: +357 22 894472	CY (NICOSIA)	hostInstitution	1˙498˙278.80

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 Obiettivo del progetto (Objective)

'Proper and controlled expression of genes is essential for normal cell growth. Chromatin modifying enzymes play a fundamental role in the control of gene expression and their deregulation is often linked to cancer. In recent years chromatin modifiers have been considered key targets for cancer therapy and this demands a full understanding of their biological functions. Previous biochemical and structural studies have focused on the identification of chromatin modifying enzymes and characterization of their substrate specificities and catalytic mechanisms. However, a comprehensive view of the biological processes, signaling pathways and regulatory circuits in which these enzymes participate is missing. Protein arginine methyltransferases (PRMTs), which methylate histones and are evolutionarily conserved from yeast to human, constitute an example of chromatin modifying enzymes whose functional and regulatory networks remain unexplored. I propose to use complementary state-of-the-art genomic and proteomic approaches in order to identify the protein networks and cellular pathways that are linked to PRMTs. In parallel, I will identify novel regulatory circuits and define the molecular mechanisms that control methylation of specific histone arginine residues. I will utilize the yeast S. cerevisiae as a model organism because it allows genetic, biochemical and genomic approaches to be combined. Most importantly, many of the pathways and mechanisms in yeast are highly conserved and therefore, the findings from this study will be pertinent to human and other eukaryotic organisms. Establishing a global cellular wiring diagram of PRMTs will serve as a paradigm for other chromatin modifiers and is imperative for assessing the efficacy of these enzymes as therapeutic targets.'