Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
Nazionalità Coordinatore | United Kingdom [UK] |
Totale costo | 171˙740 € |
EC contributo | 171˙740 € |
Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
Code Call | FP7-PEOPLE-2009-IEF |
Funding Scheme | MC-IEF |
Anno di inizio | 2010 |
Periodo (anno-mese-giorno) | 2010-03-01 - 2010-06-30 |
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1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | coordinator | 171˙740.80 |
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
'This proposal outlines a blueprint towards the development of a new catalytic strategy for chemical synthesis, wherein catalytic cascade processes are designed around the transformation of a common functional motif to a diversity of enantiopure natural product architectures, in a single step. The hypothesis behind the chemo-catalytic synthesis strategy involves the development of a catalytic enantioselective dearomatization (CED) process that directly converts flat aromatic molecules into complex asymmetric structures. The transformation involves a tandem process, comprising oxidative dearomatization and organocatalytic desymmetrization, generating highly functionalized, non-racemic architectures. The natural product targets structures of alkaloids, polyketide, steroid and terpene biosynthetic origin, and complex non-natural frameworks that may have interesting properties, as the basis for novel small-molecule libraries with untapped biological properties. The programme of research will focus on the exploitation and the development of the cascade ‘zipper-reaction’ concept, CED, wherein simple, linear molecules can be directly converted to complex enantiopure architectures that closely resemble the structures of bioactive natural products. The proposal will have four parts over the two-year period of the proposed Fellowship : the method development for the CED cascade process, the total synthesis of morphine and the development of novel scaffolds for drug discovery. The research outlined in this proposal is a representative part of a 'grand challenge' programme to provide a chemo-catalysis blueprint for synthesis that is inspired by the efficacy of biosynthesis.'
"Control of coordinated migration by the differential activation of two GPCRs, CXCR4b and CXCR7"
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