UBIQCANCER

THE ROLE OF UBIQUITYLATION AND DEUBIQUITINATION ENZYMES IN CANCER

 Coordinatore LUNDS UNIVERSITET 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Sweden [SE]
 Totale costo 1˙067˙280 €
 EC contributo 1˙067˙280 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091118
 Funding Scheme ERC-SG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-04-01   -   2016-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Dr.
Nome: Ramin
Cognome: Masoumi
Email: send email
Telefono: +4640 391175
Fax: +4640 391177

SE (LUND) hostInstitution 1˙067˙280.00
2    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Prof.
Nome: Jakob
Cognome: Testad
Email: send email
Telefono: +4640 338494
Fax: +4640 336234

SE (LUND) hostInstitution 1˙067˙280.00

Mappa


 Word cloud

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cancer    enzymes    model    tissue    tumor    melanoma    deficient    human    transgenic    genetic    progression    patients    generating    skin    mouse    ligation    drug    ubiquitin    animals    mice   

 Obiettivo del progetto (Objective)

'The overall goal of my research is to identify and characterize genetic factors leading to tumor development in human by establishing mouse models for development of anticancer drugs. The objective of the present study is to understand the function of ubiquitin ligation enzymes and deubiquitin enzymes during progression of different human skin cancers. This is analysed by generating transgenic animals and applying tumour-promoting protocol to specifically dissect the role of these enzymes during progression of cancer on mouse skin. During the proposed studies, mice deficient in various ubiquitin mediated signaling molecules such as CYLD and Bcl-3 will be used to test their contribution to cancer development. In addition we will identify novel E3 ligation and deubiquitination enzymes involved in progression of skin cancer using a multidisciplinary approach that combines mouse genetic, masspectrometry in vivo and gene expression profiling. To correlate information obtained from animal model to the development of treatments of human cancer, we are generating human tissue platforms from skin cancer patients regenerated on immune deficient mice. This model enables to study human epithelial neoplasms under in situ conditions. The results obtained in the transgenic animals as well as human tissue platform are correlated and compared to the samples from melanoma and non-melanoma human cancer patients. Furthermore, transgenic animals and transplanted human tissues are treated with proposed drug before tumor induction to test their specificity. Using state-of-the-art approaches and techniques, this project will identify novel markers for improved diagnosis and validation of candidate drug target for skin cancer therapies.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

MFMF (2012)

Market Frictions in Mathematical Finance

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AMOPROX (2010)

Quantifying Aerobic Methane Oxidation in the Ocean: Calibration and palaeo application of a novel proxy

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CDSIF (2008)

Contour dynamics and singularities in incompressible flows

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