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DiaChemo SIGNED

Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "DiaChemo" data sheet

The following table provides information about the project.

Coordinator
ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS 

Organization address
address: VIA TURI 27
city: CASTELLANA GROTTE BA
postcode: 70013
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.diachemo.eu
 Total cost 5˙240˙708 €
 EC max contribution 4˙654˙333 € (89%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS IT (CASTELLANA GROTTE BA) coordinator 293˙636.00
2    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 984˙208.00
3    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 849˙400.00
4    VERMES MICRODISPENSING GMBH DE (OTTERFING) participant 767˙250.00
5    CENTRO DI RIFERIMENTO ONCOLOGICO DI AVIANO IT (AVIANO PN) participant 716˙375.00
6    LIONIX INTERNATIONAL BV NL (ENSCHEDE) participant 587˙000.00
7    PROVENION GMBH DE (Zorneding) participant 186˙249.00
8    EUROPEAN RESEARCH SERVICES GMBH DE (MUENSTER) participant 137˙600.00
9    "INSTITUTO TUMORI ""GIOVANNI PAOLO II""" IT (BARI) participant 129˙712.00
10    FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA IT (MILANO) participant 2˙900.00
11    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 0.00
12    LIONIX BV NL (ENSCHEDE) participant 0.00

Map

 Project objective

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

 Deliverables

List of deliverables.
Project Website Websites, patent fillings, videos etc. 2019-10-14 15:52:06

Take a look to the deliverables list in detail:  detailed list of DiaChemo deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Ye Yang, Guillaume Poss, Yini Weng, Runzhang Qi, Hanrui Zheng, Nikolaos Nianias, Euan R. Kay, Stefan Guldin
Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring
published pages: 11107-11113, ISSN: 2040-3364, DOI: 10.1039/c9nr03162f
Nanoscale 11/23 2020-04-15
2018 Luis A. Serrano, Maximiliano J. Fornerod, Ye Yang, Simon Gaisford, Francesco Stellacci, Stefan Guldin
Phase behaviour and applications of a binary liquid mixture of methanol and a thermotropic liquid crystal
published pages: 4615-4620, ISSN: 1744-683X, DOI: 10.1039/c8sm00327k
Soft Matter 14/22 2020-04-15
2018 Ye Yang, Luis A. Serrano, Stefan Guldin
A Versatile AuNP Synthetic Platform for Decoupled Control of Size and Surface Composition
published pages: 6820-6826, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b00353
Langmuir 34/23 2019-10-14
2018 Niamh Mac Fhionnlaoich Stephen Schrettl Nicholas B. Tito Ye Yang Malavika Nair Luis A. Serrano Kellen Harkness Paulo Jacob Silva Holger Frauenrath Francesco Stellacci Stefan Guldin
Reversible microscale assembly of nanoparticles driven by the phase transition of a thermotropic liquid crystal
published pages: , ISSN: 0306-0012, DOI:
ChemRXIV 2019-10-14
2018 Bianca Posocco, Mauro Buzzo, Andrea Follegot, Luciana Giodini, Roberto Sorio, Elena Marangon, Giuseppe Toffoli
A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study
published pages: e0193500, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193500
PLOS ONE 13/2 2019-10-14
2018 Niamh Mac Fhionnlaoich, Stuart Ibsen, Luis A. Serrano, Alaric Taylor, Runzhang Qi, Stefan Guldin
A Toolkit to Quantify Target Compounds in Thin-Layer-Chromatography Experiments
published pages: 2191-2196, ISSN: 0021-9584, DOI: 10.1021/acs.jchemed.8b00144
Journal of Chemical Education 95/12 2019-10-14

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The information about "DIACHEMO" are provided by the European Opendata Portal: CORDIS opendata.

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