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Paragone SIGNED

PARAGONE: vaccines for animal parasites

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EC-Contrib. €

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 Paragone project word cloud

Explore the words cloud of the Paragone project. It provides you a very rough idea of what is the project "Paragone" about.

immunosuppressive    signatures    agencies    poultry    clear    pharma    china    previously    gallinae    government    ruminants    polymorphism    candidates    fundamental    drug    ectoparasitic    purpose    immunity    teladorsagia    resistance    proved    scales    immunology    ostertagia    release    move    efficiency    prototypes    antiparasitic    dwindling    farmers    fasciola    biological    huge    output    protection    exploited    dermanyssus    indiscriminate    spp    commercialisation    efficacy    paragone    inform    psoroptes    native    antiparasitics    molecules    overcome    interactions    parasite    sources    ostertagi    utilise    stakeholders    fit    mites    interrogate    circumcincta    helminth    vital    uruguay    regulators    food    vaccines    engagement    least    host    maximise    point    obtain    pathogens    alternative    supply    technologies    feedback    smes    cooperia    failed    scientists    philanthropic    adjuvants    globe    veterinarians    hepatica    vaccine    ruminant    contortus    recombinant    haemonchus    elicit    infections    geographic    led    helminths    ovis   

Project "Paragone" data sheet

The following table provides information about the project.

Coordinator
MOREDUN RESEARCH INSTITUTE 

Organization address
address: Pentlands Science Park, Bush Loan
city: PENICUIK
postcode: EH26 0PZ
website: www.moredun.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.paragoneh2020.eu/
 Total cost 8˙998˙559 €
 EC max contribution 8˙998˙559 € (100%)
 Programme 1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
 Code Call H2020-SFS-2014-2
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MOREDUN RESEARCH INSTITUTE UK (PENICUIK) coordinator 2˙173˙460.00
2    UNIVERSITEIT GENT BE (GENT) participant 1˙322˙233.00
3    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 855˙338.00
4    UNIVERSIDAD DE CORDOBA ES (CORDOBA) participant 782˙932.00
5    UNIVERSIDAD DE LA REPUBLICA UY (Montevideo) participant 531˙250.00
6    BENCHMARK ANIMAL HEALTH LIMITED UK (SHEFFIELD) participant 490˙760.00
7    THE QUEEN'S UNIVERSITY OF BELFAST UK (BELFAST) participant 467˙786.00
8    THE ROYAL VETERINARY COLLEGE UK (LONDON) participant 433˙842.00
9    IMMUNOTOOLS GMBH DE (Friesoythe) participant 346˙750.00
10    Fios Genomics Limited UK (GLASGOW) participant 301˙218.00
11    UNIVERSITY OF STRATHCLYDE UK (GLASGOW) participant 264˙517.00
12    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 254˙082.00
13    UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA ES (LAS PALMAS DE GRAN CANARIA) participant 218˙055.00
14    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 152˙163.00
15    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 131˙085.00
16    XSTALBIO LTD UK (GLASGOW) participant 115˙542.00
17    VETERINAERINSTITUTTET - NORWEGIAN VETERINARY INSTITUTE NO (OSLO) participant 97˙541.00
18    ZOETIS BELGIUM SA BE (LOUVAIN LA NEUVE) participant 60˙000.00
19    LANZHOU VETERINARY RESEARCH INSTITUTE CN (Lanzhou, Gansu) participant 0.00

Map

 Project objective

Helminth and ectoparasitic infections of ruminants and poultry have a huge impact on the biological efficiency of these vital food sources. Indiscriminate antiparasitic use has led to drug resistance across the globe. The main alternative to the dwindling supply of antiparasitics is vaccines. Here, in the PARAGONE project, findings from previous EU and other-funded projects on parasite vaccine development will be exploited to take a number of promising prototypes towards commercialisation. Partners from the Europe, China, Uruguay, SMEs and pharma, will directly move forward prototypes against the ruminant helminths Fasciola hepatica, Cooperia spp., Ostertagia ostertagi, Teladorsagia circumcincta and Haemonchus contortus and, the ectoparasitic mites, Psoroptes ovis (ruminants) and Dermanyssus gallinae (poultry). They will utilise novel adjuvants or delivery systems to maximise efficacy of some of the prototypes. Moreover, immunology studies will focus on pathogens that have previously proved problematic, often because they release immunosuppressive molecules that must be overcome for vaccines to work or because recombinant vaccines have failed to elicit protection observed with native prototypes. State-of-the-art technologies will be used to interrogate host/parasite interactions to define key signatures of protection that can be used to inform delivery systems that will enhance immunity, while other studies will define polymorphism in current vaccine candidates to ensure derived prototypes will be fit-for-purpose across geographic scales. Fundamental, is engagement of the scientists with pharma and other stakeholders (farmers, veterinarians, regulators) via many dissemination activities that will be used to obtain feedback on how the vaccines can be best deployed in the field. The output will be at least two prototypes to the point of uptake by pharma, government or philanthropic agencies, and a clear pathway to commercialisation for all prototypes studied.

 Deliverables

List of deliverables.
Stakeholder Meeting III: Stakeholders\' Input to Prototype Development Documents, reports 2020-04-06 08:25:54
Immunological Tools Workshop Documents, reports 2020-04-06 08:25:54
F. hepatica phenotypes Documents, reports 2020-04-06 08:25:54
PARAGONE website established Websites, patent fillings, videos etc. 2020-04-06 08:25:54

Take a look to the deliverables list in detail:  detailed list of Paragone deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Jorge F. González, Julia N. Hernández, Cynthia Machín, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet
Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria
published pages: 1-7, ISSN: 1297-9716, DOI: 10.1186/s13567-019-0646-y
Veterinary Research 50/1 2020-04-06
2018 Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas
Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization
published pages: 46-52, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2018.06.011
Veterinary Parasitology 258 2020-04-06
2018 Krystyna Cwiklinski, John P. Dalton
Advances in Fasciola hepatica research using ‘omics’ technologies
published pages: 321-331, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2017.12.001
International Journal for Parasitology 48/5 2020-04-06
2017 Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy
Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00485
Frontiers in Immunology 8 2020-04-06
2016 Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill
Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor
published pages: e0004601, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0004601
PLOS Neglected Tropical Diseases 10/4 2020-04-06
2018 Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly
The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.01.050
Journal of Allergy and Clinical Immunology 2020-04-06
2016 Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O\'Sullivan, Paul A. McGettigan, Grace Mulcahy
Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection
published pages: e0005015, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005015
PLOS Neglected Tropical Diseases 10/9 2020-04-06
2016 David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton
Unexpected Activity of a Novel Kunitz-type Inhibitor
published pages: 19220-19234, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.724344
Journal of Biological Chemistry 291/37 2020-04-06
2019 I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. Martínez-Moreno, J. Pérez
Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37672-7
Scientific Reports 9/1 2020-04-06
2015 Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O\'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson
The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis
published pages: 3258-3273, ISSN: 1535-9476, DOI: 10.1074/mcp.M115.053934
Molecular & Cellular Proteomics 14/12 2020-04-06
2018 Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy
Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes
published pages: 958-968, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2018.01.020
Vaccine 36/7 2020-04-06
2016 A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. Martínez-Moreno, V. Molina-Hernández, A. Martínez-Moreno
Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica
published pages: 14-19, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2016.10.020
Veterinary Parasitology 230 2020-04-06
2018 Raúl Pérez-Caballero, Leandro Buffoni, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Álvaro Martínez-Moreno
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection
published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3072-5
Parasites & Vectors 11/1 2020-04-06
2016 Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly
A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis
published pages: 37789, ISSN: 2045-2322, DOI: 10.1038/srep37789
Scientific Reports 6 2020-04-06
2018 Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni
Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3250-5
Parasites & Vectors 11/1 2020-04-06
2016 L. Garza-Cuartero, J. O\'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy
Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response
published pages: 387-402, ISSN: 0141-9838, DOI: 10.1111/pim.12326
Parasite Immunology 38/7 2020-04-06
2016 K. Cwiklinski, S. M. O\'Neill, S. Donnelly, J. P. Dalton
A prospective view of animal and human Fasciolosis
published pages: 558-568, ISSN: 0141-9838, DOI: 10.1111/pim.12343
Parasite Immunology 38/9 2020-04-06
2018 Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O\'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton
Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host
published pages: 792-809, ISSN: 1535-9476, DOI: 10.1074/mcp.RA117.000445
Molecular & Cellular Proteomics 17/4 2020-04-06
2016 Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response
published pages: 29496, ISSN: 2045-2322, DOI: 10.1038/srep29496
Scientific Reports 6 2020-04-06
2016 A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep
published pages: 84-88, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2015.12.013
Veterinary Parasitology 216 2020-04-06
2018 Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora
published pages: 41-49, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2017.07.002
International Journal for Parasitology 48/1 2020-04-06
2016 James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley
Impeding movement of the poultry red mite, Dermanyssus gallinae
published pages: 104-107, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2016.06.006
Veterinary Parasitology 225 2020-04-06
2016 R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly
The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages
published pages: 1 - 11, ISSN: 0892-6638, DOI: 10.1096/fj.201500093R
The FASEB Journal 28/09/2016 2020-04-06
2017 I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. Martínez-Moreno, J. Pérez
Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica
published pages: 61-65, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2017.03.022
Veterinary Parasitology 238 2020-04-06
2017 A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. Martínez-Cruz, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep
published pages: 49-53, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2017.03.015
Veterinary Parasitology 238 2020-04-06
2016 Alessandra Ravidà, Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O\'Neill
Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host
published pages: 3139-3153, ISSN: 1535-9476, DOI: 10.1074/mcp.M116.059774
Molecular & Cellular Proteomics 15/10 2020-04-06
2016 C. Carmona, J.F. Tort
Fasciolosis in South America: epidemiology and control challenges
published pages: 1-11, ISSN: 0022-149X, DOI: 10.1017/S0022149X16000560
Journal of Helminthology 2020-04-06
2016 Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy
Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans
published pages: e0004688, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0004688
PLOS Neglected Tropical Diseases 10/5 2020-04-06
2019 Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews
The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta
published pages: 257-265, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2018.10.006
International Journal for Parasitology 49/3-4 2020-04-06

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