Explore the words cloud of the ProteinFactory project. It provides you a very rough idea of what is the project "ProteinFactory" about.
The following table provides information about the project.
ACADEMISCH ZIEKENHUIS GRONINGEN
|Coordinator Country||Netherlands [NL]|
|Total cost||3˙685˙072 €|
|EC max contribution||3˙685˙072 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2015-01-01 to 2018-12-31|
Take a look of project's partnership.
|1||ACADEMISCH ZIEKENHUIS GRONINGEN||NL (GRONINGEN)||coordinator||383˙061.00|
|2||STOCKHOLMS UNIVERSITET||SE (STOCKHOLM)||participant||790˙977.00|
|3||UNIVERSITY OF KENT||UK (CANTERBURY, KENT)||participant||546˙575.00|
|4||INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT||FR (PARIS CEDEX 07)||participant||525˙751.00|
|5||UNIVERSITAET GREIFSWALD||DE (GREIFSWALD)||participant||498˙432.00|
|6||NOVOZYMES A/S||DK (BAGSVAERD)||participant||290˙081.00|
|7||CELLTECH R&D LIMITED||UK (SLOUGH)||participant||273˙287.00|
|8||HUMBOLDT-UNIVERSITAET ZU BERLIN||DE (BERLIN)||participant||249˙216.00|
|9||DSM FOOD SPECIALTIES BV||NL (DELFT)||participant||127˙687.00|
|10||UCB PHARMA SA||BE (BRUXELLES)||participant||0.00|
|11||ABERA BIOSCIENCE AB||SE (Stockholm)||partner||0.00|
The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and membrane proteins. There is an overwhelming need for new production systems that can deliver these products in greater yields, with higher quality and at lower costs. The 'ProteinFactory' ETN will meet these challenges through the provision of a suite of super-secreting strains with unique capabilities. These strains will be engineered to bypass major production bottlenecks such as secretion stress, and will be capable of secreting an unprecedented range of target molecules. Equally important will be the training of a new generation of researchers, versed in Systems and Synthetic Biology approaches. The ProteinFactory project will involve extensive collaboration between 6 academic Institutes, who provide world-leading expertise in synthetic biology and protein secretion, and 5 non-academic partners who include some of the world's premier biotechnology companies. Training will be inter-sectoral from the outset, with every ESR undertaking extensive secondments within the non-academic partners in order to encourage an entrepreneurial mind-set. The project is furthermore explicitly multi-disciplinary in scope, with two of the five research work packages dominated by theoretical approaches. Based on a responsible innovation approach and with a clear focus on inter-sectoral collaboration, ProteinFactory will deliver a cohort of superbly-trained scientists, put the industrial and SME partners at the forefront of global competition and reinforce European innovation potentials with growth and job creation.
|Validated membrane protein complexes and their dynamics||Documents, reports||2019-07-24 10:30:56|
|Membrane proteome data sets for B. subtilis + E. coli under all growth regimes||Documents, reports||2019-07-24 10:30:56|
|Model for protein trafficking through the secretory pathway||Documents, reports||2019-07-24 10:31:15|
|Global quantitative analysis of membrane proteome||Documents, reports||2019-07-24 10:28:23|
|New algorithms that predict inter-helix pairings in membrane proteins||Documents, reports||2019-07-24 10:30:52|
|New method for predicting membrane protein complexes||Documents, reports||2019-07-24 10:30:52|
|Global models for protein secretion and secretion stress progression||Documents, reports||2019-07-24 10:30:55|
|Secretion bottlenecks identified||Documents, reports||2019-07-10 14:40:13|
|Supervisory board of the network established||Documents, reports||2019-07-10 14:40:13|
|First quantitative data for selected membrane proteins||Documents, reports||2019-07-10 14:40:13|
|Project website.||Websites, patent fillings, videos etc.||2019-07-10 14:40:13|
|List of common and critical conditions that are relevant during industrial fermentation processes||Documents, reports||2019-07-10 14:40:13|
|Refined regulatory model including membrane proteins validated with proteomics data||Documents, reports||2019-07-24 10:30:52|
|Definition of protein production stress responses in E. coli||Documents, reports||2019-07-24 10:30:54|
|Established model for secretion stress onset||Documents, reports||2019-07-24 10:30:51|
Take a look to the deliverables list in detail: detailed list of ProteinFactory deliverables.
|year||authors and title||journal||last update|
Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea SchlÃ¼ter, Gilles Malherbe, Susanne Sievers, Daniela ZÃ¼hlke, Thomas Sura, Emma Dave, Katharina Riedel, Colin Robinson
Comparative proteome analysis in an Escherichia coli CyDisCo strain identifies stress responses related to protein production, oxidative stress and accumulation of misfolded protein
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-019-1071-7
|Microbial Cell Factories 18/1||2019-07-10|
Katarzyna M. Dolata, Isabel Guerrero Montero, Wayne Miller, Susanne Sievers, Thomas Sura, Christian Wolff, Rabea SchlÃ¼ter, Katharina Riedel, Colin Robinson
Far-reaching cellular consequences of tat deletion in Escherichia coli revealed by comprehensive proteome analyses
published pages: 97-107, ISSN: 0944-5013, DOI: 10.1016/j.micres.2018.10.008
|Microbiological Research 218||2019-07-10|
George A. Sutherland, Katie J. Grayson, Nathan B. P. Adams, Daphne M. J. Mermans, Alexander S. Jones, Angus J. Robertson, Dirk B. Auman, Amanda A. Brindley, Fabio Sterpone, Pierre Tuffery, Philippe Derreumaux, P. Leslie Dutton, Colin Robinson, Andrew Hitchcock, C. Neil Hunter
Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo â€“designed heme protein
published pages: 6672-6681, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000880
|Journal of Biological Chemistry 293/18||2019-07-10|
Suruchi Nepal, Florian Bonn, Stefano Grasso, Tim Stobernack, Anne de Jong, Kai Zhou, Ronald Wedema, Sigrid Rosema, DÃ¶rte Becher, Andreas Otto, John W. Rossen, Jan Maarten van Dijl, Erik Bathoorn
An ancient family of mobile genomic islands introducing cephalosporinase and carbapenemase genes in Enterobacteriaceae
published pages: 1377-1389, ISSN: 2150-5594, DOI: 10.1080/21505594.2018.1509666
Grietje Kuipers, Alexandros Karyolaimos, Zhe Zhang, Nurzian Ismail, Gianluca Trinco, David VikstrÃ¶m, Dirk Jan Slotboom, Jan-Willem de Gier
The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-017-0840-4
|Microbial Cell Factories 16/1||2019-07-10|
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The information about "PROTEINFACTORY" are provided by the European Opendata Portal: CORDIS opendata.