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ProteinFactory SIGNED

Engineering of new-generation protein secretion systems

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ProteinFactory" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.proteinfactory-msca-itn.eu
 Total cost 3˙685˙072 €
 EC max contribution 3˙685˙072 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 383˙061.00
2    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 790˙977.00
3    UNIVERSITY OF KENT UK (CANTERBURY, KENT) participant 546˙575.00
4    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) participant 525˙751.00
5    UNIVERSITAET GREIFSWALD DE (GREIFSWALD) participant 498˙432.00
6    NOVOZYMES A/S DK (BAGSVAERD) participant 290˙081.00
7    CELLTECH R&D LIMITED UK (SLOUGH) participant 273˙287.00
8    HUMBOLDT-UNIVERSITAET ZU BERLIN DE (BERLIN) participant 249˙216.00
9    DSM FOOD SPECIALTIES BV NL (DELFT) participant 127˙687.00
10    UCB PHARMA SA BE (BRUXELLES) participant 0.00
11    ABERA BIOSCIENCE AB SE (Stockholm) partner 0.00

Map

 Project objective

The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and membrane proteins. There is an overwhelming need for new production systems that can deliver these products in greater yields, with higher quality and at lower costs. The 'ProteinFactory' ETN will meet these challenges through the provision of a suite of super-secreting strains with unique capabilities. These strains will be engineered to bypass major production bottlenecks such as secretion stress, and will be capable of secreting an unprecedented range of target molecules. Equally important will be the training of a new generation of researchers, versed in Systems and Synthetic Biology approaches. The ProteinFactory project will involve extensive collaboration between 6 academic Institutes, who provide world-leading expertise in synthetic biology and protein secretion, and 5 non-academic partners who include some of the world's premier biotechnology companies. Training will be inter-sectoral from the outset, with every ESR undertaking extensive secondments within the non-academic partners in order to encourage an entrepreneurial mind-set. The project is furthermore explicitly multi-disciplinary in scope, with two of the five research work packages dominated by theoretical approaches. Based on a responsible innovation approach and with a clear focus on inter-sectoral collaboration, ProteinFactory will deliver a cohort of superbly-trained scientists, put the industrial and SME partners at the forefront of global competition and reinforce European innovation potentials with growth and job creation.

 Deliverables

List of deliverables.
Validated membrane protein complexes and their dynamics Documents, reports 2019-07-24 10:30:56
Membrane proteome data sets for B. subtilis + E. coli under all growth regimes Documents, reports 2019-07-24 10:30:56
Model for protein trafficking through the secretory pathway Documents, reports 2019-07-24 10:31:15
Global quantitative analysis of membrane proteome Documents, reports 2019-07-24 10:28:23
New algorithms that predict inter-helix pairings in membrane proteins Documents, reports 2019-07-24 10:30:52
New method for predicting membrane protein complexes Documents, reports 2019-07-24 10:30:52
Global models for protein secretion and secretion stress progression Documents, reports 2019-07-24 10:30:55
Secretion bottlenecks identified Documents, reports 2019-07-10 14:40:13
Supervisory board of the network established Documents, reports 2019-07-10 14:40:13
First quantitative data for selected membrane proteins Documents, reports 2019-07-10 14:40:13
Project website. Websites, patent fillings, videos etc. 2019-07-10 14:40:13
List of common and critical conditions that are relevant during industrial fermentation processes Documents, reports 2019-07-10 14:40:13
Refined regulatory model including membrane proteins validated with proteomics data Documents, reports 2019-07-24 10:30:52
Definition of protein production stress responses in E. coli Documents, reports 2019-07-24 10:30:54
Established model for secretion stress onset Documents, reports 2019-07-24 10:30:51

Take a look to the deliverables list in detail:  detailed list of ProteinFactory deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea Schlüter, Gilles Malherbe, Susanne Sievers, Daniela Zühlke, Thomas Sura, Emma Dave, Katharina Riedel, Colin Robinson
Comparative proteome analysis in an Escherichia coli CyDisCo strain identifies stress responses related to protein production, oxidative stress and accumulation of misfolded protein
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-019-1071-7
Microbial Cell Factories 18/1 2019-07-10
2019 Katarzyna M. Dolata, Isabel Guerrero Montero, Wayne Miller, Susanne Sievers, Thomas Sura, Christian Wolff, Rabea Schlüter, Katharina Riedel, Colin Robinson
Far-reaching cellular consequences of tat deletion in Escherichia coli revealed by comprehensive proteome analyses
published pages: 97-107, ISSN: 0944-5013, DOI: 10.1016/j.micres.2018.10.008
Microbiological Research 218 2019-07-10
2018 George A. Sutherland, Katie J. Grayson, Nathan B. P. Adams, Daphne M. J. Mermans, Alexander S. Jones, Angus J. Robertson, Dirk B. Auman, Amanda A. Brindley, Fabio Sterpone, Pierre Tuffery, Philippe Derreumaux, P. Leslie Dutton, Colin Robinson, Andrew Hitchcock, C. Neil Hunter
Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo –designed heme protein
published pages: 6672-6681, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000880
Journal of Biological Chemistry 293/18 2019-07-10
2018 Suruchi Nepal, Florian Bonn, Stefano Grasso, Tim Stobernack, Anne de Jong, Kai Zhou, Ronald Wedema, Sigrid Rosema, Dörte Becher, Andreas Otto, John W. Rossen, Jan Maarten van Dijl, Erik Bathoorn
An ancient family of mobile genomic islands introducing cephalosporinase and carbapenemase genes in Enterobacteriaceae
published pages: 1377-1389, ISSN: 2150-5594, DOI: 10.1080/21505594.2018.1509666
Virulence 9/1 2019-07-10
2017 Grietje Kuipers, Alexandros Karyolaimos, Zhe Zhang, Nurzian Ismail, Gianluca Trinco, David Vikström, Dirk Jan Slotboom, Jan-Willem de Gier
The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-017-0840-4
Microbial Cell Factories 16/1 2019-07-10

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