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ProteinFactory SIGNED

Engineering of new-generation protein secretion systems

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ProteinFactory project word cloud

Explore the words cloud of the ProteinFactory project. It provides you a very rough idea of what is the project "ProteinFactory" about.

institutes inter secretion bottlenecks proteinfactory companies severe bacteria limitations secreting 78 trained bypass mind reinforce scope super scientists entrepreneurial forefront quality engineered stress cytoplasm involve packages secondments rising world innovation industrial biopharmaceuticals biology equally generation enzymes esr extensive unprecedented cohort suite handle academic favoured outset superbly strategy responsible training membrane global encourage sme job billion recombinant platforms potentials etn molecules undertaking yields disciplinary strains dominated sectoral explicitly clear provision put proteins biotechnology creation synthetic secreted theoretical versed overwhelming protein market proportion lower expertise premier meet competition

Project "ProteinFactory" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.proteinfactory-msca-itn.eu
Total cost	3˙685˙072 €
EC max contribution	3˙685˙072 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	383˙061.00
2	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	790˙977.00
3	UNIVERSITY OF KENT UNIVERSITY OF KENT Organization address address: THE REGISTRY CANTERBURY city: CANTERBURY, KENT postcode: CT2 7NZ website: www.kent.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CANTERBURY, KENT)	participant	546˙575.00
4	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	participant	525˙751.00
5	UNIVERSITAET GREIFSWALD UNIVERSITAET GREIFSWALD Organization address address: DOMSTRASSE 11 city: GREIFSWALD postcode: 17489 website: www.uni-greifswald.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	498˙432.00
6	NOVOZYMES A/S NOVOZYMES A/S Organization address address: Krogshoejvej 36 city: BAGSVAERD postcode: 2880 website: www.novozymes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	290˙081.00
7	CELLTECH R&D LIMITED CELLTECH R&D LIMITED Organization address address: 208 BATH ROAD city: SLOUGH postcode: SL1 3WE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SLOUGH)	participant	273˙287.00
8	HUMBOLDT-UNIVERSITAET ZU BERLIN HUMBOLDT-UNIVERSITAET ZU BERLIN Organization address address: UNTER DEN LINDEN 6 city: BERLIN postcode: 10117 website: www.hu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	249˙216.00
9	DSM FOOD SPECIALTIES BV DSM FOOD SPECIALTIES BV Organization address address: ALEXANDER FLEMINGLAAN 1 city: DELFT postcode: 2613 AX website: www.dsmfoodspecialties.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	127˙687.00
10	UCB PHARMA SA UCB PHARMA SA Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00
11	ABERA BIOSCIENCE AB ABERA BIOSCIENCE AB Organization address address: n.a. city: Stockholm postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Stockholm)	partner	0.00

Map

Project objective

The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and membrane proteins. There is an overwhelming need for new production systems that can deliver these products in greater yields, with higher quality and at lower costs. The 'ProteinFactory' ETN will meet these challenges through the provision of a suite of super-secreting strains with unique capabilities. These strains will be engineered to bypass major production bottlenecks such as secretion stress, and will be capable of secreting an unprecedented range of target molecules. Equally important will be the training of a new generation of researchers, versed in Systems and Synthetic Biology approaches. The ProteinFactory project will involve extensive collaboration between 6 academic Institutes, who provide world-leading expertise in synthetic biology and protein secretion, and 5 non-academic partners who include some of the world's premier biotechnology companies. Training will be inter-sectoral from the outset, with every ESR undertaking extensive secondments within the non-academic partners in order to encourage an entrepreneurial mind-set. The project is furthermore explicitly multi-disciplinary in scope, with two of the five research work packages dominated by theoretical approaches. Based on a responsible innovation approach and with a clear focus on inter-sectoral collaboration, ProteinFactory will deliver a cohort of superbly-trained scientists, put the industrial and SME partners at the forefront of global competition and reinforce European innovation potentials with growth and job creation.

Deliverables

List of deliverables.
Validated membrane protein complexes and their dynamics	Documents, reports	2019-07-24 10:30:56
Membrane proteome data sets for B. subtilis + E. coli under all growth regimes	Documents, reports	2019-07-24 10:30:56
Model for protein trafficking through the secretory pathway	Documents, reports	2019-07-24 10:31:15
Global quantitative analysis of membrane proteome	Documents, reports	2019-07-24 10:28:23
New algorithms that predict inter-helix pairings in membrane proteins	Documents, reports	2019-07-24 10:30:52
New method for predicting membrane protein complexes	Documents, reports	2019-07-24 10:30:52
Global models for protein secretion and secretion stress progression	Documents, reports	2019-07-24 10:30:55
Secretion bottlenecks identified	Documents, reports	2019-07-10 14:40:13
Supervisory board of the network established	Documents, reports	2019-07-10 14:40:13
First quantitative data for selected membrane proteins	Documents, reports	2019-07-10 14:40:13
Project website.	Websites, patent fillings, videos etc.	2019-07-10 14:40:13
List of common and critical conditions that are relevant during industrial fermentation processes	Documents, reports	2019-07-10 14:40:13
Refined regulatory model including membrane proteins validated with proteomics data	Documents, reports	2019-07-24 10:30:52
Definition of protein production stress responses in E. coli	Documents, reports	2019-07-24 10:30:54
Established model for secretion stress onset	Documents, reports	2019-07-24 10:30:51

Take a look to the deliverables list in detail: detailed list of ProteinFactory deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea SchlÃ¼ter, Gilles Malherbe, Susanne Sievers, Daniela ZÃ¼hlke, Thomas Sura, Emma Dave, Katharina Riedel, Colin Robinson Comparative proteome analysis in an Escherichia coli CyDisCo strain identifies stress responses related to protein production, oxidative stress and accumulation of misfolded protein published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-019-1071-7	Microbial Cell Factories 18/1	2019-07-10
2019	Katarzyna M. Dolata, Isabel Guerrero Montero, Wayne Miller, Susanne Sievers, Thomas Sura, Christian Wolff, Rabea SchlÃ¼ter, Katharina Riedel, Colin Robinson Far-reaching cellular consequences of tat deletion in Escherichia coli revealed by comprehensive proteome analyses published pages: 97-107, ISSN: 0944-5013, DOI: 10.1016/j.micres.2018.10.008	Microbiological Research 218	2019-07-10
2018	George A. Sutherland, Katie J. Grayson, Nathan B. P. Adams, Daphne M. J. Mermans, Alexander S. Jones, Angus J. Robertson, Dirk B. Auman, Amanda A. Brindley, Fabio Sterpone, Pierre Tuffery, Philippe Derreumaux, P. Leslie Dutton, Colin Robinson, Andrew Hitchcock, C. Neil Hunter Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo â€“designed heme protein published pages: 6672-6681, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000880	Journal of Biological Chemistry 293/18	2019-07-10
2018	Suruchi Nepal, Florian Bonn, Stefano Grasso, Tim Stobernack, Anne de Jong, Kai Zhou, Ronald Wedema, Sigrid Rosema, DÃ¶rte Becher, Andreas Otto, John W. Rossen, Jan Maarten van Dijl, Erik Bathoorn An ancient family of mobile genomic islands introducing cephalosporinase and carbapenemase genes in Enterobacteriaceae published pages: 1377-1389, ISSN: 2150-5594, DOI: 10.1080/21505594.2018.1509666	Virulence 9/1	2019-07-10
2017	Grietje Kuipers, Alexandros Karyolaimos, Zhe Zhang, Nurzian Ismail, Gianluca Trinco, David VikstrÃ¶m, Dirk Jan Slotboom, Jan-Willem de Gier The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-017-0840-4	Microbial Cell Factories 16/1	2019-07-10

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The information about "PROTEINFACTORY" are provided by the European Opendata Portal: CORDIS opendata.