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AEGLE (Ancient Greek: Αá¼´γλη) – An analytics framework for integrated and personalized healthcare services in Europe

Total Cost €


EC-Contrib. €






 AEGLE project word cloud

Explore the words cloud of the AEGLE project. It provides you a very rough idea of what is the project "AEGLE" about.

3vs    diseases    local    domain    realize    clinical    analysing    quantified    stakeholders    ngs    communication    extraction    provision    semantics    critical    custom    cloud    multiparametric    data    evolution    visualization    versatility    care    dynamic    services    aegle    health    databases    big    ict    handling    estimators    speed    pca    hpc    located    resource    demands    regulatory    business    fast    modal    coupled    acceleration    metrics    computing    solution    bio    3v    volume    integration    multidimensional    computational    medical    border    analytics    efficiency    aggregated    linear    combination    chain    led    solutions    medication    biodata    estimates    parametric    decision    malignant    biostreams    ecosystem    algorithms    techniques    coming    time    limited    heterogeneous    infrastructures    allocation    found    estimation    ehrs    informatics    technologies    innovative    bottlenecks    space    cross    landscape    platform    velocity    molecular    lingual    chronic    systemic   

Project "AEGLE" data sheet

The following table provides information about the project.


Organization address
address: ESTIAS 1 & MESOGEION 73-75
city: ATHINA
postcode: 11526
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website
 Total cost 6˙079˙642 €
 EC max contribution 5˙230˙698 € (86%)
 Programme 1. H2020-EU. (Content technologies and information management: ICT for digital content, cultural and creative industries)
 Code Call H2020-ICT-2014-1
 Funding Scheme IA
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
4    MAXELER TECHNOLOGIES LIMITED UK (LONDON) participant 541˙187.00
8    TIME.LEX BE (BRUSSEL) participant 329˙000.00
9    UPPSALA UNIVERSITET SE (UPPSALA) participant 301˙250.00
10    MAAT FRANCE SARL FR (ARGONAY) participant 245˙481.00
12    GLOBAZ, S.A. PT (OLIVEIRA DE AZEMEIS) participant 217˙700.00


 Project objective

The data generated in the health domain is coming from heterogeneous, multi-modal, multi-lingual, dynamic and fast evolving medical technologies. Today we are found in a big health landscape characterized by large volume, versatility and velocity (3Vs) which has led to the evolution of the informatics in the big biodata domain. AEGLE project will build an innovative ICT solution addressing the whole data value chain for health based on: cloud computing enabling dynamic resource allocation, HPC infrastructures for computational acceleration and advanced visualization techniques. AEGLE will: - Realize a multiparametric platform using algorithms for analysing big biodata including features such as volume properties, communication metrics and bottlenecks, estimation of related computational resources needed, handling data versatility and managing velocity - Address the systemic health big bio-data in terms of the 3V multidimensional space, using analytics based on PCA techniques - Demonstrate AEGLE’s efficiency through the provision of aggregated services covering the 3V space of big bio-data. Specifically it will be evaluated in: a)big biostreams where the decision speed is critical and needs non-linear and multi-parametric estimators for clinical decision support within limited time, b)big-data from non-malignant diseases where the need for NGS and molecular data analytics requires the combination of cloud located resources, coupled with local demands for data and visualization, and finally c)big-data from chronic diseases including EHRs and medication, with needs for quantified estimates of important clinical parameters, semantics’ extraction and regulatory issues for integrated care - Bring together all related stakeholders, leading to integration with existing open databases, increasing the speed of AEGLE adaptation - Build a business ecosystem for the wider exploitation and targeting on cross-border production of custom multi-lingual solutions based on AEGLE.


List of deliverables.
Business and HTA framework Documents, reports 2019-05-30 17:02:34
Final system design Documents, reports 2019-05-30 17:02:30
AEGLE final strategy, business evaluation and feasibility analysis Documents, reports 2019-05-30 17:02:34
AEGLE Certification Demonstrators, pilots, prototypes 2019-05-30 17:02:19
AEGLE third prototype Demonstrators, pilots, prototypes 2019-05-30 17:02:27
Project’s Promotional material Websites, patent fillings, videos etc. 2019-05-30 17:02:18
Final components for local, cloud-level BigData Analytics and Applications Other 2019-05-30 17:02:25
Project’s Stationary Websites, patent fillings, videos etc. 2019-05-30 17:02:20
AEGLE Best Practices Open Research Data Pilot 2019-05-30 17:02:21
AEGLE product Demonstrators, pilots, prototypes 2019-05-30 17:02:25
Market Research Report Documents, reports 2019-05-30 17:02:20
Project’s Website Websites, patent fillings, videos etc. 2019-05-30 17:02:21
AEGLE Legal Framework Documents, reports 2019-05-30 17:02:17

Take a look to the deliverables list in detail:  detailed list of AEGLE deliverables.


year authors and title journal last update
List of publications.
2016 Larry Mansouri, Nikos Papakonstantinou, Stavroula Ntoufa, Kostas Stamatopoulos, Richard Rosenquist
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions
published pages: 40-48, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2016.07.005
Seminars in Cancer Biology 39 2019-05-30
2016 John Rumbold; Barbara Pierscionek
Reply to Why patients shouldn\'t “own” their medical records
published pages: 586-587, ISSN: 1087-0156, DOI: 10.1038/nbt.3615
Nature Biotechnology 34/6 2019-05-30
2016 P. Baliakas, M. Mattsson, K. Stamatopoulos, R. Rosenquist
Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?
published pages: 347-357, ISSN: 0954-6820, DOI: 10.1111/joim.12455
Journal of Internal Medicine 279/4 2019-05-30
2017 Katerina Vaporidi, Dimitris Babalis, Achilleas Chytas, Emmanuel Lilitsis, Eumorfia Kondili, Vasilis Amargianitakis, Ioanna Chouvarda, Nicos Maglaveras, Dimitris Georgopoulos
Clusters of ineffective efforts during mechanical ventilation: impact on outcome
published pages: 184-191, ISSN: 0342-4642, DOI: 10.1007/s00134-016-4593-z
Intensive Care Medicine 43/2 2019-05-30
2017 John M. M. Rumbold, Barbara K. Pierscionek
A critique of the regulation of data science in healthcare research in the European Union
published pages: , ISSN: 1472-6939, DOI: 10.1186/s12910-017-0184-y
BMC Medical Ethics 18/1 2019-05-30
2016 E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist, F Damm
EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia
published pages: 1547-1554, ISSN: 0887-6924, DOI: 10.1038/leu.2016.359
Leukemia 31/7 2019-05-30
2016 A. Vardi, A. Agathangelidis, E. Stalika, M. Karypidou, A. Siorenta, A. Anagnostopoulos, R. Rosenquist, A. Hadzidimitriou, P. Ghia, L.-A. Sutton, K. Stamatopoulos
Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia
published pages: 167-174, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-3017
Clinical Cancer Research 22/1 2019-05-30
2016 V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, R. Clifford, L.-A. Sutton, S. J. Blakemore, N. Stavroyianni, A. Agathangelidis, D. Rossi, M. Hoglund, J. Kotaskova, G. Juliusson, C. Belessi, N. Chiorazzi, P. Panagiotidis, A. W. Langerak, K. E. Smedby, D. Oscier, G. Gaidano, A. Schuh, F. Davi, C. Pott, J. C. Strefford, L. Trentin, S. Pospisilova, P. Ghia, K. Stamatopoulos, T. Sjoblom, R. Rosenquist
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
published pages: 1007-1016, ISSN: 0006-4971, DOI: 10.1182/blood-2015-10-674572
Blood 127/8 2019-05-30
2016 V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
\"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres\"
published pages: e369-e373, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.142968
Haematologica 101/9 2019-05-30
2016 V. Bikos, M. Karypidou, E. Stalika, P. Baliakas, A. Xochelli, L.-A. Sutton, G. Papadopoulos, A. Agathangelidis, E. Papadopoulou, Z. Davis, P. Algara, G. Kanellis, A. Traverse-Glehen, M. Mollejo, A. Anagnostopoulos, M. Ponzoni, D. Gonzalez, S. Pospisilova, E. Matutes, M. A. Piris, T. Papadaki, P. Ghia, R. Rosenquist, D. Oscier, N. Darzentas, D. Tzovaras, C. Belessi, A. Hadzidimitriou, K. Stamatopoulos
An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors
published pages: 2032-2040, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-15-1170
Clinical Cancer Research 22/8 2019-05-30
2017 John Mark Michael Rumbold, Barbara Pierscionek
The Effect of the General Data Protection Regulation on Medical Research
published pages: e47, ISSN: 1438-8871, DOI: 10.2196/jmir.7108
Journal of Medical Internet Research 19/2 2019-05-30
2017 Vasileios Tsoutsouras, Dimosthenis Masouros, Sotirios Xydis, Dimitrios Soudris
published pages: 1-19, ISSN: 1539-9087, DOI: 10.1145/3126562
ACM Transactions on Embedded Computing Systems 16/5s 2019-05-30
2016 L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaidano, S. Pospisilova, F. Davi, P. Ghia, K. Stamatopoulos, R. Rosenquist
Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors
published pages: 959-967, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.141812
Haematologica 101/8 2019-05-30
2016 Ioannis Kavakiotis, Aliki Xochelli, Andreas Agathangelidis, Grigorios Tsoumakas, Nicos Maglaveras, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Ioannis Vlahavas, Ioanna Chouvarda
Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of “towards analysis” in chronic lymphocytic leukaemia
published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-016-1044-3
BMC Bioinformatics 17/S5 2019-05-30
2016 K Stamatopoulos, A Agathangelidis, R Rosenquist, P Ghia
Antigen receptor stereotypy in chronic lymphocytic leukemia
published pages: 282-291, ISSN: 0887-6924, DOI: 10.1038/leu.2016.322
Leukemia 31/2 2019-05-30
2017 Lesley-Ann Sutton, Anastasia Hadzidimitriou, Panagiotis Baliakas, Andreas Agathangelidis, Anton W. Langerak, Stephan Stilgenbauer, Sarka Pospisilova, Zadie Davis, Francesco Forconi, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification
published pages: 968-971, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.165605
Haematologica 102/6 2019-05-30
2016 Georgios Zervakis, Kostas Tsoumanis, Sotirios Xydis, Dimitrios Soudris, Kiamal Pekmestzi
Design-Efficient Approximate Multiplication Circuits Through Partial Product Perforation
published pages: 3105-3117, ISSN: 1063-8210, DOI: 10.1109/TVLSI.2016.2535398
IEEE Transactions on Very Large Scale Integration (VLSI) Systems 24/10 2019-05-30
2017 Ioannis Kavakiotis, Olga Tsave, Athanasios Salifoglou, Nicos Maglaveras, Ioannis Vlahavas, Ioanna Chouvarda
Machine Learning and Data Mining Methods in Diabetes Research
published pages: 104-116, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2016.12.005
Computational and Structural Biotechnology Journal 15 2019-05-30
2016 P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference
published pages: e299-e302, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.140202
Haematologica 101/7 2019-05-30
2017 John Rumbold, Barbara Pierscionek
Does your electronic butler owe you a duty of confidentiality?
published pages: , ISSN: 2194-4164, DOI: 10.9785/cri-2017-0206
Computer Law Review International 18/2 2019-05-30
2016 S. Pospisilova, L.-A. Sutton, J. Malcikova, E. Tausch, D. Rossi, E. Montserrat, C. Moreno, K. Stamatopoulos, G. Gaidano, R. Rosenquist, P. Ghia
Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?
published pages: 263-265, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.139246
Haematologica 101/3 2019-05-30
2016 Chrysi Panopoulou, Christos Maramis, Nicos Maglaveras, Ioanna Chouvarda
Novel Methods for Correcting Next Generation Sequencing Errors in the β Chainof T Cell Receptors
published pages: 529-534, ISSN: , DOI: 10.1007/978-3-319-32703-7_103
2016 R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond
published pages: 1002-1009, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.134510
Haematologica 101/9 2019-05-30
2016 Kostas Siozios, Dimitrios Soudris
A Customizable Framework for Application Implementation onto 3-D FPGAs
published pages: 1-1, ISSN: 0278-0070, DOI: 10.1109/TCAD.2016.2529421
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 2019-05-30
2016 Achilleas Chytas, Katerina Vaporidi, Dimitris Babalis, Dimitris Georgopoulos, Nicos Maglaveras, Ioanna Chouvarda
Ineffective Efforts in ICU Assisted Ventilation: Feature Extraction and Analysis Platform
published pages: 642-650, ISSN: , DOI: 10.1007/978-3-319-44944-9_57
2015 Lazaros Papadopoulos, Ivan Walulya, Philippas Tsigas, Dimitris Soudris
A Systematic Methodology for Optimization of Applications Utilizing Concurrent Data Structures
published pages: 1-1, ISSN: 0018-9340, DOI: 10.1109/TC.2015.2479604
IEEE Transactions on Computers 2019-05-30

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