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TROPSENSE SIGNED

Development of a non-invassive breath test for early diagnosis of tropical diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 TROPSENSE project word cloud

Explore the words cloud of the TROPSENSE project. It provides you a very rough idea of what is the project "TROPSENSE" about.

standardised    dengue    nanomaterials    america    maghreb    sensors    spectroscopy    follow    fingerprints    pattern    risk    organic    complementary    safe    procedure    either    carbon    analytical    discriminative    diagnosis    obtaining    gold    identification    enrolled    volatile    attractive    models    pristine    multisensors    methodology    types    vocs    miniaturised    affinity    biomarkers    obtain    molecules    hydrophobic    data    demonstrating    south    patient    maximising    recognition    point    nanotubes    quantum    nanowires    basis    laser    mid    hydatidosis    techniques    chemical    functionalised    pool    employed    patients    resulyts    prototype    semiconducting    discomfort    portable    validated    breath    tropical    suitable    building    fusion    sensing    leishmaniasis    gas    possibility    samples    bio    care    diseases    feasibility    sampling    algorithms    synergic    cascade    rapid    enhanced    geographical    locations    effect    chemistry    nanoparticles    infrared    site    health    invasive   

Project "TROPSENSE" data sheet

The following table provides information about the project.

Coordinator
UPPSALA UNIVERSITET 

Organization address
address: VON KRAEMERS ALLE 4
city: UPPSALA
postcode: 751 05
website: www.uu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://h2020.tropsense.icmpp.ro
 Total cost 1˙386˙000 €
 EC max contribution 1˙386˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UPPSALA UNIVERSITET SE (UPPSALA) coordinator 18˙000.00
2    UNIVERSITAT ROVIRA I VIRGILI ES (TARRAGONA) participant 315˙000.00
3    SITEX 45 SRL RO (BUCHAREST) participant 202˙500.00
4    UNIVERSITAET ULM DE (ULM) participant 198˙000.00
5    INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU METALE NEFEROASE SIRARE-IMNR RO (PANTELIMON ILFOV) participant 184˙500.00
6    POLITECHNIKA GDANSKA PL (GDANSK) participant 126˙000.00
7    JLM INNOVATION GMBH DE (TUEBINGEN) participant 121˙500.00
8    INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI RO (IASI) participant 85˙500.00
9    MOLECULAR FINGERPRINT SWEDEN AB SE (Uppsala) participant 67˙500.00
10    UNIWERSYTECKIE CENTRUM MEDYCYNY MORSKIEJ I TROPIKALNEJ PL (GDYNIA) participant 63˙000.00
11    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) participant 4˙500.00
12    INSTITUT PASTEUR DE TUNIS TN (TUNIS) partner 0.00
13    UNIVERSIDAD DE PAMPLONA CO (PAMPLONA) partner 0.00
14    UNIVERSITE MOULAY ISMAIL MA (MEKNES) partner 0.00

Map

 Project objective

This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hydatidosis, Leishmaniasis and Dengue) from different geographical locations (Europe, South America and Maghreb). Breath sampling will follow a standardised procedure. Analytical chemistry methods will be employed for the identification of the breath volatile biomarkers of these diseases. A pool of potential nanomaterials with high affinity towards the identified VOCs will be selected (e.g., gold nanoparticles, carbon nanotubes and semiconducting nanowires, either pristine or functionalised with selected hydrophobic organic molecules and/or bio-molecules). For maximising the possibility of success of our methodology, we will investigate the synergic effect of different advanced and complementary chemical sensing techniques: Mid-Infrared Quantum Cascade Laser spectroscopy and different types of Chemical Gas Sensors devices. These techniques are particularly attractive, since they can be miniaturised and are suitable for building on-site portable systems. Advanced pattern recognition algorithms will be employed for building discriminative models for the identification of the fingerprints of the different tropical diseases studied, and multisensors data fusion will be then applied for obtaining enhanced resulyts. A point of care prototype will be proposed on the basis of the results obtained and validated on-site.

 Deliverables

List of deliverables.
Material related with formation/training and knowledge-share activities Documents, reports 2019-09-03 08:10:54
Publications and other dissemination of the results Other 2019-09-03 08:10:54
Fabrication of the nanomaterial-based devices Other 2019-09-03 08:10:53
Breath samples collection Other 2019-09-03 08:10:53
Project webpage Websites, patent fillings, videos etc. 2019-09-03 08:10:53

Take a look to the deliverables list in detail:  detailed list of TROPSENSE deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 O. Bibikova, J. Haas, A. I. López-Lorente, A. Popov, M. Kinnunen, I. Meglinski, B. Mizaikoff
Towards enhanced optical sensor performance: SEIRA and SERS with plasmonic nanostars
published pages: 951-958, ISSN: 0003-2654, DOI: 10.1039/C6AN02596J
The Analyst 142/6 2019-09-03
2017 Mohamed Fethi Diouani, Oussama Ouerghi, Amira Refai, Kamel Belgacem, Chaker Tlili, Dhafer Laouini, Makram Essafi
Detection of ESAT-6 by a label free miniature immuno-electrochemical biosensor as a diagnostic tool for tuberculosis
published pages: 465-470, ISSN: 0928-4931, DOI: 10.1016/j.msec.2016.12.051
Materials Science and Engineering: C 74 2019-09-03
2018 Carsten Jaeschke, Oriol Gonzalez, Johannes J. Glöckler, Leila T. Hagemann, Kaylen E. Richardson, Francesc Adrover, Marta Padilla, Jan Mitrovics, Boris Mizaikoff
A Novel Modular eNose System Based on Commercial MOX Sensors to Detect Low Concentrations of VOCs for Breath Gas Analysis
published pages: 993, ISSN: 2504-3900, DOI: 10.3390/proceedings2130993
Proceedings 2/13 2019-09-03
2018 Tarik Saidi, Dariusz Palmowski, Sylwia Babicz-Kiewlicz, Tesfalem Geremariam Welearegay, Nezha El Bari, Radu Ionescu, Janusz Smulko, Benachir Bouchikhi
Exhaled breath gas sensing using pristine and functionalized WO3 nanowire sensors enhanced by UV-light irradiation
published pages: 1719-1729, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.07.098
Sensors and Actuators B: Chemical 273 2019-09-03
2017 Umut Cindemir, Maciej Trawka, Janusz Smulko, Claes-Göran Granqvist, Lars Österlund, Gunnar A. Niklasson
Fluctuation-enhanced and conductometric gas sensing with nanocrystalline NiO thin films: A comparison
published pages: 132-139, ISSN: 0925-4005, DOI: 10.1016/j.snb.2016.11.015
Sensors and Actuators B: Chemical 242 2019-09-03
2016 Łukasz Lentka, Mateusz Kotarski, Janusz Smulko, Umut Cindemir, Zareh Topalian, Claes G. Granqvist, Raul Calavia, Radu Ionescu
Fluctuation-enhanced sensing with organically functionalized gold nanoparticle gas sensors targeting biomedical applications
published pages: 9-14, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2016.06.063
Talanta 160 2019-09-03
2018 Tarik Saidi, Omar Zaim, Mohammed Moufid, Nezha El Bari, Radu Ionescu, Benachir Bouchikhi
Exhaled breath analysis using electronic nose and gas chromatography–mass spectrometry for non-invasive diagnosis of chronic kidney disease, diabetes mellitus and healthy subjects
published pages: 178-188, ISSN: 0925-4005, DOI: 10.1016/j.snb.2017.10.178
Sensors and Actuators B: Chemical 257 2019-09-03
2018 Tarik Saidi, Mohammed Moufid, Omar Zaim, Nezha El Bari, Benachir Bouchikhi
Voltammetric electronic tongue combined with chemometric techniques for direct identification of creatinine level in human urine
published pages: 178-184, ISSN: 0263-2241, DOI: 10.1016/j.measurement.2017.10.044
Measurement 115 2019-09-03
2017 Tarik Saidi, Mohamed Moufid, Omar Zaim, Nezha El Bari, Radu Ionescu, Benachir Bouchikhi
Artificial Sensory Systems Combined with UV-Vis Spectrophotometry as a Robust Approach for VOCs Analysis of Human Urine and Exhaled Breath
published pages: 256-257, ISSN: 2212-0173, DOI: 10.1016/j.protcy.2017.04.110
Procedia Technology 27 2019-09-03
2017 A. Diouf, S. Motia, N. El Alami El Hassani, N. El Bari, B. Bouchikhi
Development and characterization of an electrochemical biosensor for creatinine detection in human urine based on functional molecularly imprinted polymer
published pages: 44-53, ISSN: 1572-6657, DOI: 10.1016/j.jelechem.2017.01.068
Journal of Electroanalytical Chemistry 788 2019-09-03
2018 Tesfalem Geremariam Welearegay, Umut Cindemir, Lars Österlund, Radu Ionescu
Fabrication and characterisation of ligand-functionalised ultrapure monodispersed metal nanoparticle nanoassemblies employing advanced gas deposition technique
published pages: 65603, ISSN: 0957-4484, DOI: 10.1088/1361-6528/aa9f65
Nanotechnology 29/6 2019-09-03
2018 Maher Sayhi, Oussama Ouerghi, Kamel Belgacem, Marwa Arbi, Yudum Tepeli, Abdeljalil Ghram, Ülkü Anik, Lars Österlund, Dhafer Laouini, Mohamed Fethi Diouani
Electrochemical detection of influenza virus H9N2 based on both immunomagnetic extraction and gold catalysis using an immobilization-free screen printed carbon microelectrode
published pages: 170-177, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.02.018
Biosensors and Bioelectronics 107 2019-09-03
2018 Tesfalem Geremariam Welearegay, Mohamed Fethi Diouani, Lars Österlund, Sebastian Borys, Samira Khaled, Hanen Smadhi, Florina Ionescu, Meriam Bouchekoua, Dorsaf Aloui, Dhafer Laouini, Umut Cindemir, Radu Ionescu
Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths
published pages: 101-109, ISSN: 0022-1899, DOI: 10.1093/infdis/jiy449
The Journal of Infectious Diseases 219 2019-09-03
2018 Cristhian Manuel Durán-Acevedo, Aylen Lisset Jaimes-Mogollón, Oscar Eduardo Gualdrón-Guerrero, Tesfalem Geremariam Welearegay, Julián Davíd Martinez-Marín, Juan Martín Caceres-Tarazona, Zayda Constanza Sánchez-Acevedo, Kelvin de Jesus Beleño-Saenz, Umut Cindemir, Lars Österlund, Radu Ionescu
Exhaled breath analysis for gastric cancer diagnosis in Colombian patients
published pages: 28805-28817, ISSN: 1949-2553, DOI: 10.18632/oncotarget.25331
Oncotarget 9/48 2019-09-03
2017 Radu Ionescu, Umut Cindemir, Tesfalem Geremariam Welearegay, Raul Calavia, Zouhair Haddi, Zareh Topalian, Claes-Göran Granqvist, Eduard Llobet
Fabrication of ultra-pure gold nanoparticles capped with dodecanethiol for Schottky-diode chemical gas sensing devices
published pages: 455-461, ISSN: 0925-4005, DOI: 10.1016/j.snb.2016.07.182
Sensors and Actuators B: Chemical 239 2019-09-03
2018 Carsten Jaeschke, Oriol Gonzalez, Johannes J. Glöckler, Leila T. Hagemann, Kaylen E. Richardson, Francesc Adrover, Marta Padilla, Jan Mitrovics, Boris Mizaikoff
A Novel Modular eNose System Based on Commercial MOX Sensors to Detect Low Concentrations of VOCs for Breath Gas Analysis
published pages: 993, ISSN: 2504-3900, DOI: 10.3390/proceedings2130993
Proceedings 2/13 2019-09-03
2018 Erhan Tütüncü, Markus Nägele, Steffen Becker, Marc Fischer, Johannes Koeth, Christian Wolf, Stefan Köstler, Volker Ribitsch, Andrea Teuber, Michael Gröger, Sandra Kress, Martin Wepler, Ulrich Wachter, Josef Vogt, Peter Radermacher, Boris Mizaikoff
Advanced Photonic Sensors Based on Interband Cascade Lasers for Real-Time Mouse Breath Analysis
published pages: 1743-1749, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00477
ACS Sensors 3/9 2019-09-03
2018 Nadia El Alami El Hassani, Eduard Llobet, Laura-Madalina Popescu, Mihai Ghita, Benachir Bouchikhi, Nezha El Bari
Development of a highly sensitive and selective molecularly imprinted electrochemical sensor for sulfaguanidine detection in honey samples
published pages: 647-655, ISSN: 1572-6657, DOI: 10.1016/j.jelechem.2018.07.011
Journal of Electroanalytical Chemistry 823 2019-09-03
2018 Erhan Tütüncü, Boris Mizaikoff
Cascade laser sensing concepts for advanced breath diagnostics
published pages: 1-8, ISSN: 1618-2642, DOI: 10.1007/s00216-018-1509-5
Analytical and Bioanalytical Chemistry 2019-09-03
2018 Julian Haas, Ernesto Vargas Catalán, Pierre Piron, Fredrik Nikolajeff, Lars Österlund, Mikael Karlsson, Boris Mizaikoff
Polycrystalline Diamond Thin-Film Waveguides for Mid-Infrared Evanescent Field Sensors
published pages: 6190-6198, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b00623
ACS Omega 3/6 2019-09-03
2018 J.M. Cáceres, C.M. Durán, O.E. Gualdron
Thermal Desorption System for Breath Samples Analysis from Colombian Patients with Gastric Cancer
published pages: 427-432, ISSN: 2283-9216, DOI: 10.3303/cet1868072
Chemical Engineering Transactions 68 2019-09-03
2019 Alassane Diouf, Benachir Bouchikhi, Nezha El Bari
A nonenzymatic electrochemical glucose sensor based on molecularly imprinted polymer and its application in measuring saliva glucose
published pages: 1196-1209, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.01.001
Materials Science and Engineering: C 98 2019-09-03
2018 Tesfalem Geremariam Welearegay, Mohamed Fethi Diouani, Lars Österlund, Florina Ionescu, Kamel Belgacem, Hanen Smadhi, Samira Khaled, Abdelhamid Kidar, Umut Cindemir, Dhafer Laouini, Radu Ionescu
Ligand-Capped Ultrapure Metal Nanoparticle Sensors for the Detection of Cutaneous Leishmaniasis Disease in Exhaled Breath
published pages: 2532-2540, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00759
ACS Sensors 3/12 2019-09-03
2017 Á.I. López-Lorente, M. Karlsson, L. Österlund, B. Mizaikoff
Diamond Waveguides for Infrared Spectroscopy and Sensing
published pages: , ISSN: , DOI:
Springer Series on Chemical Sensors and Biosensors (Methods and Applications) 2019-09-03
2018 Julian Haas, Ernesto Vargas Catalán, Pierre Piron, Mikael Karlsson, Boris Mizaikoff
Infrared spectroscopy based on broadly tunable quantum cascade lasers and polycrystalline diamond waveguides
published pages: 5112-5119, ISSN: 0003-2654, DOI: 10.1039/c8an00919h
The Analyst 143/21 2019-09-03
2018 Felicia Seichter, Erhan Tütüncü, Leila Tamina Hagemann, Josef Vogt, Ulrich Wachter, Michael Gröger, Sandra Kress, Peter Radermacher, Boris Mizaikoff
Online monitoring of carbon dioxide and oxygen in exhaled mouse breath via substrate-integrated hollow waveguide Fourier-transform infrared-luminescence spectroscopy
published pages: 36018, ISSN: 1752-7163, DOI: 10.1088/1752-7163/aabf98
Journal of Breath Research 12/3 2019-09-03
2018 A. Kwiatkowski, T. Chludziński, J. Smulko
Portable exhaled breath analyzer employing fluctuation-enhanced gas sensing method in resistive gas sensors
published pages: 551–560, ISSN: 0860-8229, DOI: 10.24425/123892
Metrology and Measurement Systems 25 2019-09-03
2018 A.L. Jaimes, C.M. Durán, O.E. Gualdrón, S.R. Ionescu
Stomach Cancer Detection through Exhaled Breath using Biomarkers Analysis
published pages: , ISSN: 2283-9216, DOI: 10.3303/cet1868008
68 43-48 2019-09-03
2018 Soukaina Motia, Ioan Albert Tudor, L. Madalina Popescu, Roxana Mioara Piticescu, Benachir Bouchikhi, Nezha El Bari
Development of a novel electrochemical sensor based on electropolymerized molecularly imprinted polymer for selective detection of sodium lauryl sulfate in environmental waters and cosmetic products
published pages: 553-562, ISSN: 1572-6657, DOI: 10.1016/j.jelechem.2018.03.069
Journal of Electroanalytical Chemistry 823 2019-09-03
2017 Łukasz Lentka, Janusz Smulko, Mateusz Kotarski, Claes-Göran Granqvist, Radu Ionescu
Non-Gaussian Resistance Fluctuations in Gold-Nanoparticle-Based Gas Sensors: An Appraisal of Different Evaluation Techniques
published pages: 757, ISSN: 1424-8220, DOI: 10.3390/s17040757
Sensors 17/4 2019-09-03
2018 A. Ben Slama, L. Lentka, A. Mouelhi, M.F. Diouani, M. Sayadi, J. Smulko
Application of Statistical Features and Multilayer Neural Network for Automatic Diagnosis of Arrhythmia by ECG Signals
published pages: 87-101, ISSN: 0860-8229, DOI: 10.24425/118163
Journal of Metrology and Measurement Systems 2019-09-03
2017 Ángela Inmaculada López-Lorente, Pei Wang, Boris Mizaikoff
Towards label-free mid-infrared protein assays: in-situ formation of bare gold nanoparticles for surface enhanced infrared absorption spectroscopy of bovine serum albumin
published pages: 453-462, ISSN: 0026-3672, DOI: 10.1007/s00604-016-2031-0
Microchimica Acta 184/2 2019-09-03
2016 Ángela I. López-Lorente, Javier Izquierdo, Christine Kranz, Boris Mizaikoff
Boron-doped diamond modified with gold nanoparticles for the characterization of bovine serum albumin protein
published pages: 147-156, ISSN: 0924-2031, DOI: 10.1016/j.vibspec.2016.10.010
Vibrational Spectroscopy 91 2019-09-03
2016 Per Ola Andersson, Pernilla Viberg, Pontus Forsberg, Fredrik Nikolajeff, Lars Österlund, Mikael Karlsson
Nanocrystalline diamond sensor targeted for selective CRP detection: an ATR-FTIR spectroscopy study
published pages: 3675-3680, ISSN: 1618-2642, DOI: 10.1007/s00216-016-9485-0
Analytical and Bioanalytical Chemistry 408/14 2019-09-03
2016 Ekhlas Homede, Mohammad Abo-Jabal, Radu Ionescu, Hossam Haick
Printing Ultrasensitive Artificially Intelligent Sensors Array with a Single Self-Propelled Droplet Containing Nanoparticles
published pages: 6359-6370, ISSN: 1616-301X, DOI: 10.1002/adfm.201602326
Advanced Functional Materials 26/35 2019-09-03
2016 Łukasz Lentka, Mateusz Kotarski, Janusz Smulko, Umut Cindemir, Zareh Topalian, Claes G. Granqvist, Raul Calavia, Radu Ionescu
Fluctuation-enhanced sensing with organically functionalized gold nanoparticle gas sensors targeting biomedical applications
published pages: 9-14, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2016.06.063
Talanta 160 2019-09-03
2016 Maciej Trawka, Janusz Smulko, Lech Hasse, Claes-Göran Granqvist, Fatima Ezahra Annanouch, Radu Ionescu
Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths
published pages: 453-461, ISSN: 0925-4005, DOI: 10.1016/j.snb.2016.05.032
Sensors and Actuators B: Chemical 234 2019-09-03
2018 Cristhian Manuel Durán-Acevedo, Aylen Lisset Jaimes-Mogollón, Oscar Eduardo Gualdrón-Guerrero, Tesfalem Geremariam Welearegay, Julián Davíd Martinez-Marín, Juan Martín Caceres-Tarazona, Zayda Constanza Sánchez-Acevedo, Kelvin de Jesus Beleño-Saenz, Umut Cindemir, Lars Österlund, Radu Ionescu
Exhaled breath analysis for gastric cancer diagnosis in Colombian patients
published pages: 28805-28817, ISSN: 1949-2553, DOI: 10.18632/oncotarget.25331
Oncotarget 9/48 2019-09-03
2016 T.G. Welearegay, O.E. Gualdrón, A.L. Jaimes, J.M. Cáceres, G. Pugliese, U. Cindemir, C.M. Durán, L. Österlund, R. Ionescu
Ultrapure Organically Modified Gold Nanoparticles for Breath Analysis
published pages: 133-136, ISSN: 1877-7058, DOI: 10.1016/j.proeng.2016.11.176
Procedia Engineering 168 2019-09-03
2016 Ángela I. López-Lorente, Pei Wang, Markus Sieger, Ernesto Vargas Catalan, Mikael Karlsson, Fredrik Nikolajeff, Lars Österlund, Boris Mizaikoff
Mid-infrared thin-film diamond waveguides combined with tunable quantum cascade lasers for analyzing the secondary structure of proteins
published pages: 2117-2123, ISSN: 1862-6300, DOI: 10.1002/pssa.201600134
physica status solidi (a) 213/8 2019-09-03
2017 Tarik Saidi, Mohamed Moufid, Omar Zaim, Nezha El Bari, Radu Ionescu, Benachir Bouchikhi
Artificial Sensory Systems Combined with UV-Vis Spectrophotometry as a Robust Approach for VOCs Analysis of Human Urine and Exhaled Breath
published pages: 256-257, ISSN: 2212-0173, DOI: 10.1016/j.protcy.2017.04.110
Procedia Technology 27 2019-09-03

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