Explore the words cloud of the LYMPHORG project. It provides you a very rough idea of what is the project "LYMPHORG" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||2˙368˙439 €|
|EC max contribution||2˙368˙439 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-05-01 to 2020-04-30|
Take a look of project's partnership.
|1||UPPSALA UNIVERSITET||SE (UPPSALA)||coordinator||2˙368˙439.00|
Lymphatic vasculature maintains tissue fluid homeostasis and has important emerging roles in inflammation, immunity, lipid metabolism, blood pressure regulation and cancer metastasis. Lymphatic vessels are specialised to fulfil the functional needs of different organs while diseases associated with lymphatic dysfunction frequently affect vessels of specific tissues. How functional specialisation of vessels is achieved and what underlies tissue-specific vessel failure is not understood. I hypothesise that organ-specific manifestation of lymphatic dysfunction in disease is due to vascular bed-specific differences in vessel formation. In this project my aim is to identify genes and mechanisms required for organ-specific lymphatic development. Building on our recent discovery of a previously unknown progenitor cell type that is required for lymphatic development in an organ-specific manner I set out to identify the origin and function of lymphatic endothelial progenitor cells (LEPC) during development and assess their potential for therapeutic lymphatic regeneration. Towards this aim, we will identify organ-specific origins of lymphatic vasculature using lineage tracing and determine genetic signatures of lymphatic endothelial progenitors by mRNA sequencing. Cells and tissues from normal and mutant mice that show organ-specific lymphatic defects will be analysed. To identify molecular and cellular mechanisms of LEPC derived vessel formation, we will functionally characterise LEPC signature genes using mouse models and visualise vessel development by in vivo two-photon microscopy. The function and therapeutic potential of LEPCs and LEPC derived vessels will be assessed using mouse models of tolerance, inflammation, obesity and lymphoedema. This work will provide novel insights into organ-specific mechanisms of vascular morphogenesis and identify a progenitor cell that may be expoited to restore lymphatic function in disorders associated with lymphatic vessel failure.
|year||authors and title||journal||last update|
A. Ãlvarez-Aznar, I. MartÃnez-Corral, N. Daubel, C. Betsholtz, T. MÃ¤kinen, K. Gaengel
Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines
published pages: , ISSN: 0962-8819, DOI: 10.1007/s11248-019-00177-8
Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik OrtsÃ¤ter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija MÃ¤kinen
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03959-6
|Nature Communications 9/1||2019-05-30|
Yang Zhang, Nina Daubel, Simon Stritt, Taija MÃ¤kinen
Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels
published pages: dev156745, ISSN: 0950-1991, DOI: 10.1242/dev.156745
Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija MÃ¤kinen
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03692-0
|Nature Communications 9/1||2019-05-30|
Ines Martinez-Corral, Lukas Stanczuk, Maike Frye, Maria Helena Ulvmar, Rodrigo DiÃ©guez-Hurtado, David Olmeda, Taija Makinen, Sagrario Ortega
Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system
published pages: 433-445, ISSN: 0969-6970, DOI: 10.1007/s10456-016-9505-x
Michael Potente, Taija MÃ¤kinen
Vascular heterogeneity and specialization in development and disease
published pages: 477-494, ISSN: 1471-0072, DOI: 10.1038/nrm.2017.36
|Nature Reviews Molecular Cell Biology 18/8||2019-05-30|
Yixin Wang, Yi Jin, Maarja Andaloussi MÃ¤e, Yang Zhang, Henrik OrtsÃ¤ter, Christer Betsholtz, Taija MÃ¤kinen, Lars Jakobsson
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
published pages: 3590-3601, ISSN: 0950-1991, DOI: 10.1242/dev.147967
Maria H. Ulvmar, Ines Martinez-Corral, Lukas Stanczuk, Taija MÃ¤kinen
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins
published pages: 350-358, ISSN: 1526-954X, DOI: 10.1002/dvg.22939
Maria H. Ulvmar, Taija MÃ¤kinen
Heterogeneity in the lymphatic vascular system and its origin
published pages: 310-321, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw175
|Cardiovascular Research 111/4||2019-05-30|
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