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CARBONFIX SIGNED

Towards a Self-Amplifying Carbon-Fixing Anabolic Cycle

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CARBONFIX" data sheet

The following table provides information about the project.

Coordinator
CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION 

Organization address
address: ALLEE G MONGE 8
city: STRASBOURG
postcode: 67000
website: http://www.icfrc.fr/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://moranlab.com
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION FR (STRASBOURG) coordinator 1˙500˙000.00

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 Project objective

How can simple molecules self-organize into a growing synthetic reaction network like biochemical metabolism? This proposal takes a novel synthesis-driven approach to the question by mimicking a central self-amplifying CO2-fixing biochemical reaction cycle known as the reductive tricarboxylic acid cycle. The intermediates of this cycle are the synthetic precursors to all major classes of biomolecules and are built from CO2, an anhydride and electrons from simple reducing agents. Based on the nature of the reactions in the cycle and the specific structural features of the intermediates that comprise it, we propose that the entire cycle may be enabled in a single reaction vessel with a surprisingly small number of simple, mutually compatible catalysts from the recent synthetic organic literature. However, since one of the required reactions does not yet have an efficient synthetic equivalent in the literature and since those that do have not yet been carried out sequentially in a single reaction vessel, we will first independently develop the new reaction and sequences before attempting to combine them into the entire cycle. The new reaction and sequences will be useful green synthetic methods in their own right. Most significantly, this endeavour could provide the first experimental evidence of an exciting new alternative model for early biochemical evolution that finally illuminates the origins and necessity of biochemistry’s core reactions.

 Publications

year authors and title journal last update
List of publications.
2019 A. Thomas, L. Lethuillier-Karl, K. Nagarajan, R. M. A. Vergauwe, J. George, T. Chervy, A. Shalabney, E. Devaux, C. Genet, J. Moran, T. W. Ebbesen
Tilting a ground-state reactivity landscape by vibrational strong coupling
published pages: 615-619, ISSN: 0036-8075, DOI: 10.1126/science.aau7742
Science 363/6427 2020-03-31
2019 Kamila B. Muchowska, Elodie Chevallot-Beroux, Joseph Moran
Recreating ancient metabolic pathways before enzymes
published pages: 2292-2297, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.012
Bioorganic & Medicinal Chemistry 27/12 2020-03-31
2019 Paul Chatelain, Abhijit Sau, Christopher N. Rowley, Joseph Moran
Suzuki–Miyaura Coupling of (Hetero)Aryl Sulfones: Complementary Reactivity Enables Iterative Polyaryl Synthesis
published pages: 14959-14963, ISSN: 1433-7851, DOI: 10.1002/anie.201908336
Angewandte Chemie International Edition 58/42 2020-03-31
2019 Florent Noël, Vuk D. Vuković, Jing Yi, Edward Richmond, Pavle Kravljanac, Joseph Moran
Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP
published pages: 15926-15947, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b02398
The Journal of Organic Chemistry 84/24 2020-03-31
2019 Kamila B. Muchowska, Sreejith J. Varma, Joseph Moran
Synthesis and breakdown of universal metabolic precursors promoted by iron
published pages: 104-107, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1151-1
Nature 569/7754 2020-03-31
2019 Elodie Chevallot-Beroux, Ayuk M. Ako, Wolfgang Schmitt, Brendan Twamley, Joseph Moran, Boudon Corinne, Laurent Ruhlmann, Samir Mameri
Synthesis of new Mn 19 analogues and their structural, electrochemical and catalytic properties
published pages: 4830-4836, ISSN: 1477-9226, DOI: 10.1039/c8dt04807j
Dalton Transactions 48/15 2020-03-31
2018 Edward Richmond, Jing Yi, Vuk D. Vuković, Fatima Sajadi, Christopher N. Rowley, Joseph Moran
Ring-opening hydroarylation of monosubstituted cyclopropanes enabled by hexafluoroisopropanol
published pages: 6411-6416, ISSN: 2041-6520, DOI: 10.1039/c8sc02126k
Chemical Science 9/30 2020-03-31
2020 Martina Preiner, Kensuke Igarashi, Kamila B. Muchowska, Mingquan Yu, Sreejith J. Varma, Karl Kleinermanns, Masaru K. Nobu, Yoichi Kamagata, Harun Tüysüz, Joseph Moran, William F. Martin
A hydrogen-dependent geochemical analogue of primordial carbon and energy metabolism
published pages: , ISSN: 2397-334X, DOI: 10.1038/s41559-020-1125-6
Nature Ecology & Evolution 2020-03-31
2020 Anoop Thomas, Anjali Jayachandran, Lucas Lethuillier-Karl, Robrecht M.A. Vergauwe, Kalaivanan Nagarajan, Eloise Devaux, Cyriaque Genet, Joseph Moran, Thomas W. Ebbesen
Ground state chemistry under vibrational strong coupling: dependence of thermodynamic parameters on the Rabi splitting energy
published pages: 249-255, ISSN: 2192-8614, DOI: 10.1515/nanoph-2019-0340
Nanophotonics 9/2 2020-03-31
2017 Sreejith Jayasree Varma, Kamila B. Muchowska, Paul Chatelain, Joseph Moran
Metals enable a non-enzymatic acetyl CoA pathway
published pages: , ISSN: , DOI: 10.1101/235523
bioRxiv 2019-05-29
2017 Vuk D. Vuković, Edward Richmond, Eléna Wolf, Joseph Moran
Catalytic Friedel-Crafts Reactions of Highly Electronically Deactivated Benzylic Alcohols
published pages: 3085-3089, ISSN: 1433-7851, DOI: 10.1002/anie.201612573
Angewandte Chemie International Edition 56/11 2019-05-29
2017 Kamila B. Muchowska, Sreejith J. Varma, Elodie Chevallot-Beroux, Lucas Lethuillier-Karl, Guang Li, Joseph Moran
Metals promote sequences of the reverse Krebs cycle
published pages: 1716-1721, ISSN: 2397-334X, DOI: 10.1038/s41559-017-0311-7
Nature Ecology & Evolution 1/11 2019-05-29
2018 Edward Richmond, Joseph Moran
Recent Advances in Nickel Catalysis Enabled by Stoichiometric Metallic Reducing Agents
published pages: 499-513, ISSN: 0039-7881, DOI: 10.1055/s-0036-1591853
Synthesis 50/03 2019-05-29
2018 Edward Richmond, Vuk D. Vuković, Joseph Moran
Nucleophilic Ring Opening of Donor–Acceptor Cyclopropanes Catalyzed by a Brønsted Acid in Hexafluoroisopropanol
published pages: 574-577, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b03688
Organic Letters 20/3 2019-05-29

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