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CuRE SIGNED

Cardiac REgeneration from within

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CuRE project word cloud

Explore the words cloud of the CuRE project. It provides you a very rough idea of what is the project "CuRE" about.

vivo    first    validity    infarction    arrayed    vectors    screenings    myocardial    entail    patients    involvement    lack    treatments    libraries    cytoskeleton    primary    search    proliferate    recombinant    systematic    heart    sarcomere    extend    small    innovative    cardiomyocytes    acids    stimulate    cure    capacity    complemented    therapies    proteasome    molecules    possesses    achievement    intrinsic    regeneration    biotherapeutics    leads    translational    animal    ubiquitin    synthetic    discovery    administration    secretome    mirnaome    assessing    proliferation    biotechnological    cardiac    form    basic    intermediate    aav    1200    micrornas    advantage    nucleic    urgently    proteins    800    respectively    functionally    virus    stimulating    efficacy    genes    ex    therapeutic    adeno    curative    mirnas    screened    endogenous    successful    cardiovascular    transformed    corresponding    diseases    components    cytokines    models    throughput    mouse    series    therapeutics    mirna    damage    cloned    mice    light    pri    cardiomyocyte    systematically    cell    breadth   

Project "CuRE" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙428˙492 €
 EC max contribution 2˙428˙492 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙428˙492.00

Map

 Project objective

Biotechnological therapies for patients with myocardial infarction and heart failure are urgently needed, in light of the breadth of these diseases and a lack of curative treatments. CuRE is an ambitious project aimed at identifying novel factors (cytokines, growth factors, microRNAs) that promote cardiomyocyte proliferation and can thus be transformed into innovative therapeutics to stimulate cardiac regeneration. The Project leads from two concepts: first, that cardiac regeneration can be obtained by stimulating the endogenous capacity of cardiomyocytes to proliferate, second that effective biotherapeutics might be identified through systematic screenings both in vivo and ex vivo. In the mouse, CuRE will take advantage of two unique arrayed libraries cloned in adeno-associated virus (AAV) vectors, one corresponding to the secretome (1200 factors) and the other to the miRNAome (800 pri-miRNA genes). Both libraries will be functionally screened in mice to search for factors that enhance cardiac regeneration. This in vivo selection approach will be complemented by a series of high throughput screenings on primary cardiomyocytes ex vivo, aimed at systematically assessing the involvement of all components of the ubiquitin/proteasome pathway, the cytoskeleton and the sarcomere on cell proliferation. Cytokines and miRNAs can both be developed to become therapeutic molecules, in the form of recombinant proteins and synthetic nucleic acids, respectively. Therefore, a key aim of CuRE will be to establish procedures for their production and administration in vivo, and to assess their efficacy in both small and large animal models of myocardial damage. In addition to this translational goal, the project will entail the successful achievement of several intermediate objectives, each of which possesses intrinsic validity in terms of basic discovery and is thus expected to extend technology and knowledge in the cardiovascular field beyond state-of-the art.

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The information about "CURE" are provided by the European Opendata Portal: CORDIS opendata.

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