Explore the words cloud of the Protein Lego project. It provides you a very rough idea of what is the project "Protein Lego" about.
The following table provides information about the project.
|EC max contribution
|1˙950˙000 € (100%)
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|from 2015-09-01 to 2020-08-31
Take a look of project's partnership.
|MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Proteins are ubiquitous, very diverse, and participate in virtually every cellular process. Nature has generated this impressive set of proteins using mechanisms such as recombination of smaller, sub-domain sized protein fragments that serve as building blocks in a Lego-like manner. Based on these observations we propose a rational design strategy in which new functional proteins are build from fragments of existing proteins. With this approach we aim to tackle a long-standing goal in biochemistry, namely the design of complex, custom-made proteins. Initial experiments that recombine fragments from the same as well as from different folds have been successful in creating new proteins. Moreover, the utilized fragments contribute their unique functional properties to the protein chimeras, which is a tremendous advantage of using existing subunits for the design. Here, we aim to generalize this approach. We will identify common structural fragments and classify them based on their associated functions. We will build stable hybrid proteins from different folds, transfer functional sites associated with particular fragments, and thereby learn about general design rules. The proposed approach offers a rigorous test for the identification of minimal determinants of protein structure and function. It simultaneously allows us to test our understanding of protein evolution and will have profound implications on the current view of structural classification and interactions. And lastly, the development of a reliable methodology for the design of complex proteins will be very valuable for synthetic biology and bioengineering approaches.
|authors and title
Saacnicteh Toledo-PatiÃ±o, Manish Chaubey, Murray Coles, Birte HÃ¶cker
Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor
published pages: 4790-4793, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00900
Horst Lechner, Noelia Ferruz, Birte HÃ¶cker
Strategies for designing non-natural enzymes and binders
published pages: 67-76, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2018.07.022
|Current Opinion in Chemical Biology 47
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