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gluactive SIGNED

Activation Mechanism of a Glutamate Receptor

Total Cost €

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EC-Contrib. €

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Partnership

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Project "gluactive" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSVERBUND BERLIN EV 

Organization address
address: RUDOWER CHAUSSEE 17
city: BERLIN
postcode: 12489
website: www.fv-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙981˙500 €
 EC max contribution 1˙981˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) coordinator 1˙981˙500.00

Map

 Project objective

Glutamate receptors are amongst the most important signalling molecules in the brain. Activation of receptors by the neurotransmitter glutamate is required for nervous system function, underlying cognition, learning, memory and sensation. Despite advances in the study of their structural biology and physiology, how glutamate receptor complexes are activated remains unclear. With this proposal, we aim to determine how receptor activation and desensitisation are driven by glutamate binding. Our central approach is to map the motions of glutamate receptors during synaptic-like activity, in order to grab the frames needed to produce the movie of receptor activation. We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds. Trapped receptors will be examined using biochemical measures of subunit association, biophysical reports of receptor activity and by structural biology. The results we obtain will be useful to rationally interfere with excitatory synapses in the brain and may therefore help the development of therapies.

 Publications

year authors and title journal last update
List of publications.
2018 Jelena Baranovic, Andrew JR Plested
Auxiliary subunits keep AMPA receptors compact during activation and desensitization
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40548
eLife 7 2020-03-05
2016 Andrew J.R. Plested
Single-Channel Recording of Ligand-Gated Ion Channels
published pages: pdb.top087239, ISSN: 1559-6095, DOI: 10.1101/pdb.top087239
Cold Spring Harbor Protocols 2016/8 2019-06-06
2017 Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Mechanism of partial agonism in AMPA-type glutamate receptors
published pages: 14327, ISSN: 2041-1723, DOI: 10.1038/ncomms14327
Nature Communications 8 2019-06-06
2016 Andrew J.R. Plested, Jelena Baranovic
Single-Channel Recording of Glycine Receptors in Human Embryonic Kidney (HEK) Cells
published pages: pdb.prot091652, ISSN: 1559-6095, DOI: 10.1101/pdb.prot091652
Cold Spring Harbor Protocols 2016/8 2019-06-06
2018 Alvin Yu, Héctor Salazar, Andrew J.R. Plested, Albert Y. Lau
Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics
published pages: 139-149.e4, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.11.024
Neuron 97/1 2019-06-06

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