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MOSUDO TERMINATED

Water and Drug Mobility at Silica Surfaces probed with DOSY NMR

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MOSUDO project word cloud

Explore the words cloud of the MOSUDO project. It provides you a very rough idea of what is the project "MOSUDO" about.

dancing    advantage    itself    tackle    interplay    action    cell    expertise    drug    living    near    albert    prize    gain    surfaces    dosy    unravelling    life    tune    ordered    diffusion    winner    dr    resonance    sensitivity    gy    interdisciplinary    nuclear    background    mellaerts    molecules    body    spectacular    europe    drastically    profile    society    molecule    poorly    newly    embark    pharmaceutical    contact    improvement    headline    water    shift    discarded    eyes    mosudo    randy    rely    reaching    compounds    spectroscopy    materials    direct    revolutionary    magnetic    nmr    nobel    silica    fellowship    drugs    toolbox    peptide    industry    rgyi    ouml    hurdles    amino    acquiring    bioavailability    hydrophilicity    solid    acids    multitude    faced    pharmacy    site    difficulties    surface    candidates    act    highest    mobility    szent    probing    human    membranes    recognizes    scientific    scientists    area    complement    approaching    physical    chemistry    varying    popped    solids    insufficient    paradigm    equip   

Project "MOSUDO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Europe’s pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Györgyi even described life itself as “water dancing on the tune of solids”. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry will complement his current research profile and allow him to embark at the highest scientific level in a for society very important research area.

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The information about "MOSUDO" are provided by the European Opendata Portal: CORDIS opendata.

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