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MOSUDO TERMINATED

Water and Drug Mobility at Silica Surfaces probed with DOSY NMR

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MOSUDO project word cloud

Explore the words cloud of the MOSUDO project. It provides you a very rough idea of what is the project "MOSUDO" about.

water    europe    contact    society    szent    winner    albert    molecules    paradigm    itself    eyes    nuclear    chemistry    solids    candidates    human    ouml    highest    headline    recognizes    physical    rgyi    poorly    pharmacy    profile    surfaces    approaching    resonance    near    nobel    shift    unravelling    insufficient    area    scientists    direct    fellowship    diffusion    revolutionary    rely    sensitivity    living    compounds    peptide    cell    prize    industry    act    probing    reaching    interplay    materials    scientific    action    mellaerts    molecule    complement    hurdles    site    pharmaceutical    gy    life    faced    acids    equip    embark    toolbox    drugs    acquiring    tackle    magnetic    mosudo    tune    dr    ordered    hydrophilicity    newly    discarded    expertise    popped    drug    drastically    solid    silica    bioavailability    difficulties    mobility    interdisciplinary    varying    advantage    dancing    background    spectroscopy    surface    multitude    gain    membranes    dosy    body    spectacular    randy    nmr    amino    improvement   

Project "MOSUDO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Europe’s pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Györgyi even described life itself as “water dancing on the tune of solids”. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry will complement his current research profile and allow him to embark at the highest scientific level in a for society very important research area.

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The information about "MOSUDO" are provided by the European Opendata Portal: CORDIS opendata.

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