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MOSUDO TERMINATED

Water and Drug Mobility at Silica Surfaces probed with DOSY NMR

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MOSUDO project word cloud

Explore the words cloud of the MOSUDO project. It provides you a very rough idea of what is the project "MOSUDO" about.

hurdles    magnetic    shift    mobility    water    physical    drugs    itself    area    fellowship    insufficient    surface    nmr    candidates    dosy    materials    background    europe    near    direct    newly    dr    society    silica    ouml    expertise    act    molecule    human    mosudo    life    probing    solid    diffusion    drug    paradigm    toolbox    amino    szent    prize    hydrophilicity    rely    membranes    resonance    varying    tune    solids    spectroscopy    approaching    recognizes    eyes    popped    poorly    equip    mellaerts    molecules    compounds    highest    albert    cell    scientists    gain    unravelling    discarded    gy    pharmacy    revolutionary    bioavailability    acquiring    surfaces    living    body    nuclear    difficulties    interdisciplinary    profile    scientific    advantage    headline    complement    winner    peptide    spectacular    randy    chemistry    tackle    industry    reaching    pharmaceutical    sensitivity    rgyi    embark    multitude    acids    drastically    contact    faced    dancing    action    site    interplay    ordered    nobel    improvement   

Project "MOSUDO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Europe’s pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Györgyi even described life itself as “water dancing on the tune of solids”. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry will complement his current research profile and allow him to embark at the highest scientific level in a for society very important research area.

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The information about "MOSUDO" are provided by the European Opendata Portal: CORDIS opendata.

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