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FeSensor

Finding the iron sensing protein in crop plants

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "FeSensor" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF EAST ANGLIA 

Organization address
address: EARLHAM ROAD
city: NORWICH
postcode: NR4 7TJ
website: http://www.uea.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.jic.ac.uk/directory/janneke-balk/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF EAST ANGLIA UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

Iron (Fe) is needed for all living organisms but in high concentrations within the cell it is toxic, therefore balancing the physiological level of iron is essential. Although the Fe sensing mechanism has been described for a wide variety of living forms, from bacteria to mammals, no clear information about how plants sense Fe is available. Whether or not Fe is sensed in roots or in shoots or in both, the chemical form of the Fe or the identity of the sensing protein, remains unknown. In yeast and mammals, Fe is sensed via Fe-S proteins, but in plants the Fe sensing mechanism has been shown to be independent from Fe-S cluster assembly in the mitochondria or cytosol. Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors. I would like to investigate if their putative Fe binding motifs, haemerythrin and rubredoxin, are functional in an Fe-sensing capacity. Moreover, I will investigate if the proteins have ubiquitination activity as predicted, and tissue-specific expression compatible with a double sensing mechanism in roots and leaves. Other possibilities for the Fe-sensing mechanism will be explored by using mutants defective in Fe-S assembly in the plastids, and unknown candidates will be uncovered with an unbiased mutant screening. Perturbing the Fe sensing mechanism in a tissue-specific manner would be a smart way of increasing the Fe content without causing toxicity symptoms in the rest of the plant.

 Publications

year authors and title journal last update
List of publications.
2019 Jorge Rodríguez-Celma, James M. Connorton, Inga Kruse, Robert T. Green, Marina Franceschetti, Yi-Tze Chen, Yan Cui, Hong-Qing Ling, Kuo-Chen Yeh, Janneke Balk
Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling
published pages: 17584-17591, ISSN: 0027-8424, DOI: 10.1073/pnas.1907971116
Proceedings of the National Academy of Sciences 116/35 2019-09-20
2019 Jorge Rodríguez-Celma, Hsuan Chou, Takanori Kobayashi, Terri A. Long, Janneke Balk
Hemerythrin E3 Ubiquitin Ligases as Negative Regulators of Iron Homeostasis in Plants
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00098
Frontiers in Plant Science 10 2019-09-20
2017 James M Connorton, Janneke Balk and Jorge Rodriguez-Celma
Iron homeostasis in plants - a brief overview
published pages: , ISSN: 1756-591X, DOI:
Metallomics 2019-07-23

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