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FeSensor

Finding the iron sensing protein in crop plants

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FeSensor project word cloud

Explore the words cloud of the FeSensor project. It provides you a very rough idea of what is the project "FeSensor" about.

concentrations leaves sensors candidates perturbing sense content uncovered binding identity variety rest organisms toxicity unbiased expression irs1 cytosol double iron possibilities roots yeast mutants good physiological plants plastids manner shown motifs cluster functional predicted species causing mechanism balancing independent putative chemical smart screening proteins protein rubredoxin shoots ubiquitination clear forms cell tissue living assembly mammals mitochondria genes bts bacteria small sensing plant symptoms unknown fe capacity defective haemerythrin mutant model sensed explored toxic irs2 transcriptomics form compatible family

Project "FeSensor" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.jic.ac.uk/directory/janneke-balk/
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2017-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF EAST ANGLIA UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	coordinator	183˙454.00

Map

Project objective

Iron (Fe) is needed for all living organisms but in high concentrations within the cell it is toxic, therefore balancing the physiological level of iron is essential. Although the Fe sensing mechanism has been described for a wide variety of living forms, from bacteria to mammals, no clear information about how plants sense Fe is available. Whether or not Fe is sensed in roots or in shoots or in both, the chemical form of the Fe or the identity of the sensing protein, remains unknown. In yeast and mammals, Fe is sensed via Fe-S proteins, but in plants the Fe sensing mechanism has been shown to be independent from Fe-S cluster assembly in the mitochondria or cytosol. Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors. I would like to investigate if their putative Fe binding motifs, haemerythrin and rubredoxin, are functional in an Fe-sensing capacity. Moreover, I will investigate if the proteins have ubiquitination activity as predicted, and tissue-specific expression compatible with a double sensing mechanism in roots and leaves. Other possibilities for the Fe-sensing mechanism will be explored by using mutants defective in Fe-S assembly in the plastids, and unknown candidates will be uncovered with an unbiased mutant screening. Perturbing the Fe sensing mechanism in a tissue-specific manner would be a smart way of increasing the Fe content without causing toxicity symptoms in the rest of the plant.

Publications

List of publications.
year	authors and title	journal	last update
2019	Jorge RodrÃguez-Celma, James M. Connorton, Inga Kruse, Robert T. Green, Marina Franceschetti, Yi-Tze Chen, Yan Cui, Hong-Qing Ling, Kuo-Chen Yeh, Janneke Balk Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling published pages: 17584-17591, ISSN: 0027-8424, DOI: 10.1073/pnas.1907971116	Proceedings of the National Academy of Sciences 116/35	2019-09-20
2019	Jorge RodrÃguez-Celma, Hsuan Chou, Takanori Kobayashi, Terri A. Long, Janneke Balk Hemerythrin E3 Ubiquitin Ligases as Negative Regulators of Iron Homeostasis in Plants published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00098	Frontiers in Plant Science 10	2019-09-20
2017	James M Connorton, Janneke Balk and Jorge Rodriguez-Celma Iron homeostasis in plants - a brief overview published pages: , ISSN: 1756-591X, DOI:	Metallomics	2019-07-23

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The information about "FESENSOR" are provided by the European Opendata Portal: CORDIS opendata.