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IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria

Total Cost €


EC-Contrib. €






 IgEPath project word cloud

Explore the words cloud of the IgEPath project. It provides you a very rough idea of what is the project "IgEPath" about.

diseases    reporting    health    community    secondary    mice    models    ige    physiologic    company    functions    immunity    complementarily    expertise    prof    infections    transfer    basophils    combines    knapp    infection    competence    mc    pathogens    msc    innate    allergies    vitro    antibodies    bacteria    specificity    toxin    detrimental    critical    mouse    host    translation    invasive    toxins    resistant    experimental    roles    immunoglobulin    sensitivity    connecting    career    allergic    pathogenic    induce    led    mechanisms    combination    fellowship    effector    facilitates    beneficial    bactericidal    acquired    decipher    contrast    philipp    infectious    investigates    iges    cells    reintegration    secondment    dr    sylvia    inspire    exacerbation    vaccine    atopic    venom    mcs    benefit    causing    mast    bacterial    pharmaceutical    bee    industrial    participate    starkl    vivo    disease    elusive    supporting    immune    hypothesis    strains    idea    acquisition    defense    antibiotic    transgenic   

Project "IgEPath" data sheet

The following table provides information about the project.


Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-03   to  2017-08-02


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 166˙156.00


 Project objective

In combination, Immunoglobulin E antibodies (IgEs) and IgE effector cells, most importantly mast cells (MCs) and basophils, are best known for their disease-causing roles in allergic conditions. MCs can also participate in innate host defense against pathogens and toxins. In contrast, physiologic functions of IgEs that benefit the host are still elusive. Dr. Philipp Starkl led a recent study reporting the critical role of IgEs and IgE effector cells in a beneficial type 2 immune response against bee venom in mice, supporting the idea that allergies represent defense mechanisms against toxins. Toxins that induce IgE development are also produced by various pathogenic bacteria. IgE production during bacterial infection has been considered detrimental since it is associated with the exacerbation of atopic diseases. This study investigates the hypothesis that toxin-specific IgEs can be important for acquired immunity against pathogenic bacteria by increasing the sensitivity, extent and specificity of the bactericidal MC response. The main objective of this study is to decipher the roles of IgEs and IgE effector cells in host defense against invasive secondary infections with antibiotic resistant pathogenic bacteria, which are a major health problem in Europe. The experimental approach facilitates knowledge transfer between the US and EU and complementarily combines the applicant’s expertise in type 2 immunity, IgEs and MCs (acquired in the US) and Prof. Sylvia Knapp’s competence in bacterial infections and involves in vivo mouse models of infection in transgenic mouse strains and MC in vitro models. The secondment in a pharmaceutical company will inspire collaboration and translation of results into vaccine development. This MSC fellowship will support the applicant’s career development by fostering acquisition of novel expertise in infectious diseases, collaboration with and reintegration into the European research community and connecting with the industrial sector.


year authors and title journal last update
List of publications.
2016 Kaori Mukai, Mindy Tsai, Philipp Starkl, Thomas Marichal, Stephen J. Galli
IgE and mast cells in host defense against parasites and venoms
published pages: 581-603, ISSN: 1863-2297, DOI: 10.1007/s00281-016-0565-1
Seminars in Immunopathology 38/5 2019-06-13

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The information about "IGEPATH" are provided by the European Opendata Portal: CORDIS opendata.

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