EU H2020 Project "IGEPATH (IgEPath - Contributions of IgE-antibodies and IgE effector cells to host..)": description, partecipants, costs and EC-fundings

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IgEPath project word cloud

Explore the words cloud of the IgEPath project. It provides you a very rough idea of what is the project "IgEPath" about.

acquired connecting facilitates translation msc innate causing participate immune mcs disease effector mc pharmaceutical idea secondary sylvia reintegration combines bactericidal transgenic expertise infectious diseases philipp basophils venom bee induce bacterial immunity atopic invasive toxins fellowship exacerbation supporting iges functions dr mice roles elusive antibiotic led company strains complementarily vitro antibodies ige vivo physiologic toxin mouse cells knapp mechanisms beneficial health models bacteria specificity vaccine allergic sensitivity benefit contrast industrial starkl pathogenic experimental decipher competence hypothesis community detrimental career immunoglobulin investigates inspire combination infections critical acquisition resistant defense reporting prof host mast infection allergies pathogens transfer secondment

Project "IgEPath" data sheet

The following table provides information about the project.

Coordinator	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	https://innere-med-1.meduniwien.ac.at/forschungslabor-infektionsbiologie-research-lab-infectionbiology/
Total cost	166˙156 €
EC max contribution	166˙156 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-RI
Starting year	2015
Duration (year-month-day)	from 2015-08-03 to 2017-08-02

#	participants	country	role	EC contrib. [€]
1	MEDIZINISCHE UNIVERSITAET WIEN	AT (WIEN)	coordinator	166˙156.00

MEDIZINISCHE UNIVERSITAET WIEN

AT (WIEN)

coordinator

166˙156.00

Project objective

In combination, Immunoglobulin E antibodies (IgEs) and IgE effector cells, most importantly mast cells (MCs) and basophils, are best known for their disease-causing roles in allergic conditions. MCs can also participate in innate host defense against pathogens and toxins. In contrast, physiologic functions of IgEs that benefit the host are still elusive. Dr. Philipp Starkl led a recent study reporting the critical role of IgEs and IgE effector cells in a beneficial type 2 immune response against bee venom in mice, supporting the idea that allergies represent defense mechanisms against toxins. Toxins that induce IgE development are also produced by various pathogenic bacteria. IgE production during bacterial infection has been considered detrimental since it is associated with the exacerbation of atopic diseases. This study investigates the hypothesis that toxin-specific IgEs can be important for acquired immunity against pathogenic bacteria by increasing the sensitivity, extent and specificity of the bactericidal MC response. The main objective of this study is to decipher the roles of IgEs and IgE effector cells in host defense against invasive secondary infections with antibiotic resistant pathogenic bacteria, which are a major health problem in Europe. The experimental approach facilitates knowledge transfer between the US and EU and complementarily combines the applicant’s expertise in type 2 immunity, IgEs and MCs (acquired in the US) and Prof. Sylvia Knapp’s competence in bacterial infections and involves in vivo mouse models of infection in transgenic mouse strains and MC in vitro models. The secondment in a pharmaceutical company will inspire collaboration and translation of results into vaccine development. This MSC fellowship will support the applicant’s career development by fostering acquisition of novel expertise in infectious diseases, collaboration with and reintegration into the European research community and connecting with the industrial sector.

Publications

List of publications.
year	authors and title	journal	last update
2016	Kaori Mukai, Mindy Tsai, Philipp Starkl, Thomas Marichal, Stephen J. Galli IgE and mast cells in host defense against parasites and venoms published pages: 581-603, ISSN: 1863-2297, DOI: 10.1007/s00281-016-0565-1	Seminars in Immunopathology 38/5	2019-06-13

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