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BBLOCK

Stereocontrolled synthesis of polypropionates based on building block assembly strategies by lithiation-borylation methodologies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BBLOCK project word cloud

Explore the words cloud of the BBLOCK project. It provides you a very rough idea of what is the project "BBLOCK" about.

permit    sharing    antitumoral    complete    organic    polypropionates    chemistry    natural    hydroxy    lithiation    chiral    attractive    polyketides    antiparasitic    stereochemically    molecules    posses    envisioned    agents    synthetic    spectrum    demonstrated    block    generating    synthesis    constitute    varying    permutations    molecule    structural    successful    centre    relative    too    herein    platform    amongst    methodology    bristol    plan    antibiotic    streptovaricin    combining    career    strategy    innovative    tools    power    analogues    class    complexity    sequences    borylation    polypropionate    core    capitalize    preparation    building    construction    centres    broad    biological    disseminating    training    compounds    stereochemistry    possibility    biomedical    facilitated    antifungal    modify    made    shortcut    methyl    assembly    bearing    therapeutic    eg    stereochemical    university    transferring    stereogenic    fragments    length    blocks    construct    absolute   

Project "BBLOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.chm.bris.ac.uk/org/aggarwal/former_members.php
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.

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The information about "BBLOCK" are provided by the European Opendata Portal: CORDIS opendata.

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