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BBLOCK

Stereocontrolled synthesis of polypropionates based on building block assembly strategies by lithiation-borylation methodologies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BBLOCK project word cloud

Explore the words cloud of the BBLOCK project. It provides you a very rough idea of what is the project "BBLOCK" about.

power    assembly    analogues    demonstrated    relative    molecule    disseminating    strategy    stereochemistry    sequences    therapeutic    attractive    shortcut    biomedical    modify    envisioned    antifungal    synthesis    combining    broad    possibility    construction    generating    streptovaricin    synthetic    length    university    blocks    chiral    molecules    tools    methodology    antibiotic    block    bearing    antiparasitic    centre    varying    absolute    complete    polypropionate    transferring    compounds    organic    herein    class    antitumoral    fragments    successful    natural    posses    agents    too    structural    career    polyketides    permit    amongst    facilitated    constitute    sharing    polypropionates    lithiation    construct    stereochemically    centres    made    stereogenic    hydroxy    biological    chemistry    core    innovative    training    permutations    capitalize    borylation    building    methyl    plan    eg    platform    preparation    stereochemical    spectrum    complexity    bristol   

Project "BBLOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.chm.bris.ac.uk/org/aggarwal/former_members.php
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.

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The information about "BBLOCK" are provided by the European Opendata Portal: CORDIS opendata.

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