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Stereocontrolled synthesis of polypropionates based on building block assembly strategies by lithiation-borylation methodologies

Total Cost €


EC-Contrib. €






 BBLOCK project word cloud

Explore the words cloud of the BBLOCK project. It provides you a very rough idea of what is the project "BBLOCK" about.

blocks    assembly    training    plan    possibility    herein    university    building    antitumoral    fragments    synthesis    strategy    tools    permutations    antifungal    eg    stereogenic    capitalize    chiral    streptovaricin    block    disseminating    spectrum    centres    agents    stereochemistry    sharing    analogues    borylation    hydroxy    permit    length    preparation    therapeutic    molecules    too    innovative    modify    generating    compounds    bristol    bearing    constitute    platform    attractive    synthetic    structural    stereochemical    shortcut    biomedical    broad    transferring    biological    amongst    absolute    complexity    molecule    construction    varying    organic    power    facilitated    construct    career    centre    stereochemically    lithiation    natural    antiparasitic    class    methodology    chemistry    relative    envisioned    successful    sequences    polyketides    antibiotic    posses    methyl    complete    made    demonstrated    polypropionates    core    combining    polypropionate   

Project "BBLOCK" data sheet

The following table provides information about the project.


Organization address
postcode: BS8 1QU

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00


 Project objective

Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.

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The information about "BBLOCK" are provided by the European Opendata Portal: CORDIS opendata.

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