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Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Total Cost €


EC-Contrib. €






 TARGET SLEEP project word cloud

Explore the words cloud of the TARGET SLEEP project. It provides you a very rough idea of what is the project "TARGET SLEEP" about.

optimal    reduces    hour    students    nap    anticipate    preserved    validated    functioning    sequence    population    reactivation    combination    stimuli    exposure    markers    manipulating    gap    societal    therapeutic    tmr    wellbeing    rigorous    works    adding    compare    communication    controls    neuroscientific    diminish    learning    patients    facilitates    wake    parkinson    effect    effectiveness    time    interventions    astonishing    disease    gained    adults    sleep    period    adaptations    ageing    leadership    integrating    daytime    lacking    behavioral    connections    projected    reinforce    spark    plan    whereby    first    benefits    neural    neuroimaging    auditory    memory    experimentally    techniques    rehabilitation    replayed    healthy    suggested    consolidating    strategy    daily    imperative    imprint    msca    age    learned    teaching    newly    training    underlying    boost    matched    motor    consolidation    skills    supervising    concretely    pd    network    difficulty    formed   

Project "TARGET SLEEP" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Rehabilitation is an important therapeutic strategy for patients with Parkinson’s disease (PD), whereby motor adaptations are learned to maintain daily functioning. However, patients often present difficulty consolidating newly learned skills into long-term memory, which reduces the benefits of training. Interventions that enhance consolidation are therefore projected to diminish the impact of PD. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted memory reactivation (TMR). TMR works by adding associated auditory stimuli during learning, which are replayed during sleep and thus reinforce the recently formed neural connections. Importantly, recent work has suggested that consolidation during sleep may be preserved in PD, but robust findings are lacking and have not involved TMR. This knowledge gap is astonishing given the potential benefits that can be gained by integrating sleep interventions into rehabilitation. My objective is to address this imperative by investigating the effect of sleep on motor memory consolidation by experimentally manipulating exposure to sleep and TMR for the first time. Concretely, I will compare the effect of a 2-hour daytime nap with or without TMR to that of a wake control period in PD and age-matched controls. I will use a validated motor sequence task to test for behavioral markers of motor learning and apply state-of-the-art neuroimaging techniques to study the imprint of neural network changes underlying consolidation. My training objectives include teaching and supervising students in rehabilitation–related neuroscientific topics and research leadership development. I will also implement a rigorous dissemination and communication plan to achieve optimal societal impact of my research findings. I anticipate my MSCA to spark new sleep interventions that boost the effectiveness of rehabilitation and improve the wellbeing of our ageing population, in particular those affected by PD.

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The information about "TARGET SLEEP" are provided by the European Opendata Portal: CORDIS opendata.

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