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Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Total Cost €


EC-Contrib. €






 TARGET SLEEP project word cloud

Explore the words cloud of the TARGET SLEEP project. It provides you a very rough idea of what is the project "TARGET SLEEP" about.

auditory    training    astonishing    adaptations    controls    integrating    exposure    replayed    gained    daily    imperative    functioning    reduces    supervising    motor    boost    concretely    therapeutic    anticipate    consolidating    suggested    leadership    lacking    rigorous    optimal    benefits    works    reactivation    plan    parkinson    sequence    behavioral    effectiveness    experimentally    learning    wellbeing    patients    gap    msca    validated    network    whereby    matched    population    daytime    tmr    memory    difficulty    neuroimaging    neuroscientific    effect    markers    preserved    compare    pd    teaching    communication    strategy    age    first    adding    disease    manipulating    reinforce    consolidation    period    hour    techniques    healthy    projected    imprint    ageing    skills    sleep    spark    connections    underlying    facilitates    diminish    formed    adults    rehabilitation    combination    stimuli    students    newly    neural    learned    time    interventions    wake    societal    nap   

Project "TARGET SLEEP" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Rehabilitation is an important therapeutic strategy for patients with Parkinson’s disease (PD), whereby motor adaptations are learned to maintain daily functioning. However, patients often present difficulty consolidating newly learned skills into long-term memory, which reduces the benefits of training. Interventions that enhance consolidation are therefore projected to diminish the impact of PD. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted memory reactivation (TMR). TMR works by adding associated auditory stimuli during learning, which are replayed during sleep and thus reinforce the recently formed neural connections. Importantly, recent work has suggested that consolidation during sleep may be preserved in PD, but robust findings are lacking and have not involved TMR. This knowledge gap is astonishing given the potential benefits that can be gained by integrating sleep interventions into rehabilitation. My objective is to address this imperative by investigating the effect of sleep on motor memory consolidation by experimentally manipulating exposure to sleep and TMR for the first time. Concretely, I will compare the effect of a 2-hour daytime nap with or without TMR to that of a wake control period in PD and age-matched controls. I will use a validated motor sequence task to test for behavioral markers of motor learning and apply state-of-the-art neuroimaging techniques to study the imprint of neural network changes underlying consolidation. My training objectives include teaching and supervising students in rehabilitation–related neuroscientific topics and research leadership development. I will also implement a rigorous dissemination and communication plan to achieve optimal societal impact of my research findings. I anticipate my MSCA to spark new sleep interventions that boost the effectiveness of rehabilitation and improve the wellbeing of our ageing population, in particular those affected by PD.

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The information about "TARGET SLEEP" are provided by the European Opendata Portal: CORDIS opendata.

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