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BaCTher

Bacteria for Cancer Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BaCTher project word cloud

Explore the words cloud of the BaCTher project. It provides you a very rough idea of what is the project "BaCTher" about.

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Project "BaCTher" data sheet

The following table provides information about the project.

Coordinator
ISTITUTO SUPERIORE DI SANITA 

Organization address
address: Viale Regina Elena 299
city: ROMA
postcode: 161
website: http://www.iss.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.iss.it/spva/index.php
 Total cost 164˙203 €
 EC max contribution 164˙203 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTITUTO SUPERIORE DI SANITA IT (ROMA) coordinator 164˙203.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

Cancer is the second cause of death in the western world and it is expected to become the leading one in developing countries in the next future. The long-term outcome of BaCTher is the improvement of the cancer treatment that can overcome the intrinsic limitations of the current therapies through the development of a new promising therapeutic strategy. The specific hypothesis behind the proposed research is that an attenuated Salmonella enterica serovar Typhimurium (STMΔznuABC) is able to influence the tumor microenvironment (TME) reprogramming or re-educating the immune response, and inducing a shift from protumorigenic inflammation to anticancer immunity, which results in a tumor growth control. This hypothesis is based on the observation that: 1) there is compelling scientific evidence of the effect of bacteria, and in particular Salmonella, against cancer growth; 2) STMΔznuABC is able to reduce cancer growth and to increase the average life expectancy in a mammary adenocarcinoma Balb/c mice model; 3) STMΔznuABC is able to penetrate and proliferate into the tumor cells inhibiting the proliferation of tumor cells at 24h post-treatment. Three specific aims are designed to: 1) investigate the relationship between STMΔznuABC and TME; 2) characterize the mechanism of STMΔznuABC antitumor activity; 3) validate the results obtained in the preliminary studies using alternative in vivo models. The Experienced Researcher (ER), from the Istituto Superiore di Sanità (ISS), Italy, will spend one year at the Cancer Immunobiology Section of the Cancer and Inflammation Program (CIP), Center for Cancer Research (CCR), division of the National Cancer Institute (NCI), Bethesda, MD USA, for mutual exchange of skills and know-how that will be transferred back to the beneficiary organisation (ISS), contributing to the establishment of a wider long-term collaboration between the ER and host institutions.

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The information about "BACTHER" are provided by the European Opendata Portal: CORDIS opendata.

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