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Bacteria for Cancer Therapy

Total Cost €


EC-Contrib. €






 BaCTher project word cloud

Explore the words cloud of the BaCTher project. It provides you a very rough idea of what is the project "BaCTher" about.

compelling    bethesda    attenuated    world    post    iss    typhimurium    immunobiology    establishment    immunity    cells    salmonella    proliferation    inducing    nci    reduce    designed    shift    er    division    treatment    alternative    outcome    western    bacther    vivo    national    strategy    scientific    md    ccr    death    immune    protumorigenic    model    italy    mutual    expectancy    delta    skills    reprogramming    life    transferred    therapeutic    cancer    therapies    validate    section    24h    countries    improvement    models    researcher    relationship    influence    effect    mammary    exchange    antitumor    educating    usa    anticancer    host    limitations    adenocarcinoma    preliminary    mice    enterica    center    penetrate    superiore    beneficiary    tme    back    spend    intrinsic    organisation    stm    re    overcome    znuabc    hypothesis    microenvironment    cip    bacteria    istituto    serovar    inflammation    mechanism    tumor    agrave    di    proliferate    inhibiting    sanit    balb    observation   

Project "BaCTher" data sheet

The following table provides information about the project.


Organization address
address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 164˙203 €
 EC max contribution 164˙203 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTITUTO SUPERIORE DI SANITA IT (ROMA) coordinator 164˙203.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00


 Project objective

Cancer is the second cause of death in the western world and it is expected to become the leading one in developing countries in the next future. The long-term outcome of BaCTher is the improvement of the cancer treatment that can overcome the intrinsic limitations of the current therapies through the development of a new promising therapeutic strategy. The specific hypothesis behind the proposed research is that an attenuated Salmonella enterica serovar Typhimurium (STMΔznuABC) is able to influence the tumor microenvironment (TME) reprogramming or re-educating the immune response, and inducing a shift from protumorigenic inflammation to anticancer immunity, which results in a tumor growth control. This hypothesis is based on the observation that: 1) there is compelling scientific evidence of the effect of bacteria, and in particular Salmonella, against cancer growth; 2) STMΔznuABC is able to reduce cancer growth and to increase the average life expectancy in a mammary adenocarcinoma Balb/c mice model; 3) STMΔznuABC is able to penetrate and proliferate into the tumor cells inhibiting the proliferation of tumor cells at 24h post-treatment. Three specific aims are designed to: 1) investigate the relationship between STMΔznuABC and TME; 2) characterize the mechanism of STMΔznuABC antitumor activity; 3) validate the results obtained in the preliminary studies using alternative in vivo models. The Experienced Researcher (ER), from the Istituto Superiore di Sanità (ISS), Italy, will spend one year at the Cancer Immunobiology Section of the Cancer and Inflammation Program (CIP), Center for Cancer Research (CCR), division of the National Cancer Institute (NCI), Bethesda, MD USA, for mutual exchange of skills and know-how that will be transferred back to the beneficiary organisation (ISS), contributing to the establishment of a wider long-term collaboration between the ER and host institutions.

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The information about "BACTHER" are provided by the European Opendata Portal: CORDIS opendata.

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