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Bacteria for Cancer Therapy

Total Cost €


EC-Contrib. €






 BaCTher project word cloud

Explore the words cloud of the BaCTher project. It provides you a very rough idea of what is the project "BaCTher" about.

bethesda    stm    bacther    inducing    usa    proliferation    organisation    scientific    division    nci    world    mammary    transferred    24h    hypothesis    antitumor    limitations    host    er    section    inhibiting    preliminary    delta    istituto    establishment    tme    vivo    bacteria    znuabc    adenocarcinoma    salmonella    beneficiary    md    observation    expectancy    serovar    therapeutic    immune    cancer    inflammation    compelling    attenuated    life    iss    strategy    relationship    national    protumorigenic    back    exchange    researcher    therapies    cip    superiore    italy    ccr    post    penetrate    effect    sanit    countries    treatment    intrinsic    death    proliferate    western    alternative    educating    model    re    overcome    mechanism    immunobiology    validate    reprogramming    agrave    immunity    center    enterica    di    tumor    anticancer    skills    typhimurium    balb    microenvironment    mutual    outcome    improvement    spend    cells    designed    shift    reduce    influence    mice    models   

Project "BaCTher" data sheet

The following table provides information about the project.


Organization address
address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 164˙203 €
 EC max contribution 164˙203 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTITUTO SUPERIORE DI SANITA IT (ROMA) coordinator 164˙203.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00


 Project objective

Cancer is the second cause of death in the western world and it is expected to become the leading one in developing countries in the next future. The long-term outcome of BaCTher is the improvement of the cancer treatment that can overcome the intrinsic limitations of the current therapies through the development of a new promising therapeutic strategy. The specific hypothesis behind the proposed research is that an attenuated Salmonella enterica serovar Typhimurium (STMΔznuABC) is able to influence the tumor microenvironment (TME) reprogramming or re-educating the immune response, and inducing a shift from protumorigenic inflammation to anticancer immunity, which results in a tumor growth control. This hypothesis is based on the observation that: 1) there is compelling scientific evidence of the effect of bacteria, and in particular Salmonella, against cancer growth; 2) STMΔznuABC is able to reduce cancer growth and to increase the average life expectancy in a mammary adenocarcinoma Balb/c mice model; 3) STMΔznuABC is able to penetrate and proliferate into the tumor cells inhibiting the proliferation of tumor cells at 24h post-treatment. Three specific aims are designed to: 1) investigate the relationship between STMΔznuABC and TME; 2) characterize the mechanism of STMΔznuABC antitumor activity; 3) validate the results obtained in the preliminary studies using alternative in vivo models. The Experienced Researcher (ER), from the Istituto Superiore di Sanità (ISS), Italy, will spend one year at the Cancer Immunobiology Section of the Cancer and Inflammation Program (CIP), Center for Cancer Research (CCR), division of the National Cancer Institute (NCI), Bethesda, MD USA, for mutual exchange of skills and know-how that will be transferred back to the beneficiary organisation (ISS), contributing to the establishment of a wider long-term collaboration between the ER and host institutions.

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The information about "BACTHER" are provided by the European Opendata Portal: CORDIS opendata.

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