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LQTS-HORSES

Platform for diagnosing long QT syndrome in horses - Step II: Identification of long QT syndrome

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "LQTS-HORSES" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://ecg.ku.dk/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The Equine Cardiac Group at the University of Copenhagen has established a platform for diagnosing long QT syndrome (LQTS) in horses. In men, this condition is a cause of severe ventricular arrhythmias leading to death in some cases. The pathophysiological mechanism behind this disturbance of the cardiac rhythm is a delayed repolarisation often associated with reduced function of voltage gated potassium (K-) channels. LQTS is one of the cardiac causes of sudden death in athletes. Sudden deaths occurring during public events have a highly negative impact on the public perception about high performance sports, both in men and in horses, and raise concerns about animal welfare especially in the racing industry. With the new tools developed by the Equine Cardiac Group the presence of LQTS will be investigated in horses by screening ECGs from a large pool of horses with different genetic backgrounds. Genetic sequencing will be performed on blood samples from this population and from horses with sudden death to describe genetic polymorphisms or mutations in the K-channels. The identified equine sequences will be compared to those described for men and the function of the identified mutations will be characterized electrophysiologically using voltage-clamp techniques, generating then new insights into the pathophysiology of LQTS in horses. The benefit of the proposed project will be triple: 1) It will allow for identification of LQTS in horses and will aim at developing a reliable diagnostic test to screen horses for LQTS; 2) It will enable us to exclude them form racing and to reduce sudden deaths during sport events and therefore it will increase safety and animal welfare in racing industry, an important economic factor for many European areas; 3) Similitudes between men and horses in regard to the pathophysiology of LQTS might establish horses as a valuable model for investigating disturbances of repolarisation, especially those occurring in highly trained athletes.

 Publications

year authors and title journal last update
List of publications.
2017 Philip J. Pedersen, Kirsten B. Thomsen, Jon B. Flak, Maria A. Tejada, Frank Hauser, Dagmar Trachsel, Rikke Buhl, Theodore Kalbfleisch, Michael Scott DePriest, James N. MacLeod, Kirstine Calloe, Dan A. Klaerke
Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium
published pages: 79-86, ISSN: 0034-5288, DOI: 10.1016/j.rvsc.2017.09.010
Research in Veterinary Science 113 2019-07-23
2016 P.J. Pedersen, M. Karlsson, M. Flethøj, D.S. Trachsel, J.K. Kanters, D.A. Klaerke, R. Buhl
Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise
published pages: 255-264, ISSN: 1760-2734, DOI: 10.1016/j.jvc.2016.02.002
Journal of Veterinary Cardiology 18/3 2019-07-23

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The information about "LQTS-HORSES" are provided by the European Opendata Portal: CORDIS opendata.

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