Explore the words cloud of the CoordinGrowthDev project. It provides you a very rough idea of what is the project "CoordinGrowthDev" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||173˙076 €|
|EC max contribution||173˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-03-01 to 2018-06-20|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||173˙076.00|
Over the recent years, research in developmental biology has stumbled upon the problem of how development ensures that organisms achieve appropriate body and organ size. The coordination of organ growth with the developmental program is essential for the emergence of adults with proper body size and proportions. These species-specific features condition many traits of adult life such as fitness and survival. Studies on fruit flies have allowed setting up the conceptual frame for this research. Our current understanding is that tissue growth and the developmental program are synchronized by feedback control mechanisms that block the transition to the next developmental period until all tissues have completed growth.
Recent work in Drosophila has started unraveling the nature of the signals that couple tissue growth with developmental progression. A newly discovered Drosophila insulin-like peptide called Dilp8 is key in this coupling, raising the possibility that peptides with similar roles may exist in vertebrates. The current project aims at characterizing the molecular mechanisms by which Dilp8 coordinates development of the different body parts. First, I will conduct a biased genetic screen to identify the receptor for Dilp8. This will allow a better characterization of the biological functions of Dilp8. On one hand, I will unravel the target tissues of Dilp8 mediating regulation of steroid hormone and developmental transitions. On the other hand, I will investigate the role of Dilp8 signaling in coordinating growth among developing organs.
The project will shed light on the mechanisms of inter-organ communication that ensure the coordination of growth between tissues and with the developmental timing. The expertise of the host laboratory, combined the conceptual frame and experimental approaches of the project, will allow me to gain new skills and scientific knowledge, and to develop a successful research career in the field of growth control.
|year||authors and title||journal||last update|
Julien Colombani, DitteÂ S. Andersen, Laura Boulan, Emilie Boone, Nuria Romero, Virginie Virolle, Michael Texada, Pierre LÃ©opold
Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability
published pages: 2723-2729, ISSN: 0960-9822, DOI: 10.1016/j.cub.2015.09.020
|Current Biology 25/20||2019-06-13|
Emilie Boone, Laura Boulan, Ditte S. Andersen, Nuria Romero, Pierre LÃ©opold, Julien Colombani
Des insulines pour orchestrer laÂ croissance
published pages: 637-641, ISSN: 0767-0974, DOI: 10.1051/medsci/20173306021
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The information about "COORDINGROWTHDEV" are provided by the European Opendata Portal: CORDIS opendata.
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