Explore the words cloud of the PEARS project. It provides you a very rough idea of what is the project "PEARS" about.
The following table provides information about the project.
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-06-01 to 2017-05-31|
Take a look of project's partnership.
|1||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||coordinator||195˙454.00|
Streptococcus pneumoniae (the pneumococcus) is a bacterial species generally commensal to humans, but which occasionally causes infections responsible for the death of 800, 000 infants each year worldwide. Multiple genotypes exhibiting resistance to antibiotics have emerged in past years. Intriguingly, despite extensive antibiotic consumption operating strong selection for resistance, the latter remains at a stable frequency, 15% on average over the last 20 years in Europe. This is paradoxical, as robust coexistence of resistant and sensitive strains is unexpected under the simplest epidemiological models. In this project, I will investigate the possibility that coexistence is instead maintained by a more complex mechanism, relying on local adaptation to several niches characterized by different rates of antibiotic administration. I will develop a series of novel models with increasing realism and relevance to the context of S. pneumoniae, drawing from the often separate fields of population genetics and epidemiology. Starting with simple but general two- and multiple-niches models that allow for analytical solutions to provide initial insights, I will then build a more complex simulation model parameterized with biologically realistic contact and treatment structures. Output of this model will be confronted to large-scale patterns of spatial variation in resistance observed in epidemiological datasets. The analysis of these models will help us understand what factors facilitate the maintenance of coexistence in S. pneumoniae. This work may lead to better treatment policies to manage antibiotic resistance in this major pathogen.
|year||authors and title||journal||last update|
FranÃ§ois Blanquart, Myriam Valero, Catharina Alves-de-Souza, Aliou Dia, FrÃ©dÃ©ric Lepelletier, Estelle Bigeard, Christian Jeanthon, Christophe Destombe, Laure Guillou
Evidence for parasite-mediated selection during short-lasting toxic algal blooms
published pages: 20161870, ISSN: 0962-8452, DOI: 10.1098/rspb.2016.1870
|Proceedings of the Royal Society B: Biological Sciences 283/1841||2019-07-24|
FranÃ§ois Blanquart, Sonja Lehtinen, Christophe Fraser
An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae
published pages: 20170679, ISSN: 0962-8452, DOI: 10.1098/rspb.2017.0679
|Proceedings of the Royal Society B: Biological Sciences 284/1855||2019-07-24|
FranÃ§ois Blanquart, Mary Kate Grabowski, Joshua Herbeck, Fred Nalugoda, David Serwadda, Michael A Eller, Merlin L Robb, Ronald Gray, Godfrey Kigozi, Oliver Laeyendecker, Katrina A Lythgoe, Gertrude Nakigozi, Thomas C Quinn, Steven J Reynolds, Maria J Wawer, Christophe Fraser
A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.20492
Sonja Lehtinen, FranÃ§ois Blanquart, Nicholas J. Croucher, Paul Turner, Marc Lipsitch, Christophe Fraser
Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage
published pages: 1075-1080, ISSN: 0027-8424, DOI: 10.1073/pnas.1617849114
|Proceedings of the National Academy of Sciences 114/5||2019-07-24|
Susan F. Bailey, FranÃ§ois Blanquart, Thomas Bataillon, Rees Kassen
What drives parallel evolution?
published pages: e201600176, ISSN: 0265-9247, DOI: 10.1002/bies.201600176
Katrina A. Lythgoe, FranÃ§ois Blanquart, Lorenzo Pellis, Christophe Fraser
Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics
published pages: e1002567, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002567
|PLOS Biology 14/10||2019-07-24|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PEARS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PEARS" are provided by the European Opendata Portal: CORDIS opendata.
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and IconographyRead More
Role of the SWI/SNF complex in the Androgen Receptor cistrome regulationRead More
Quantum Topological PolaritonicsRead More