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PTALLENEST

Platinum-Catalysed Reaction of Bis-Allenes with Nucleophiles: Mechanistic Insights and Future Applications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PTALLENEST" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF EAST ANGLIA 

Organization address
address: EARLHAM ROAD
city: NORWICH
postcode: NR4 7TJ
website: http://www.uea.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.uea.ac.uk/chemistry/people/profile/m-munoz-herranz
 Total cost 91˙727 €
 EC max contribution 91˙727 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-13   to  2016-04-12

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF EAST ANGLIA UK (NORWICH) coordinator 91˙727.00

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 Project objective

For some time allenes were considered simple curiosities because of their apparent unstable nature. However, in the last few years the chemistry of allenes has been extensively developed since they have shown an interesting reactivity and selectivity affording complex structures in an atom economic manner. Bis-allenes have recently appeared as useful building blocks for the synthesis of carbo- and heterocycles. However, their reaction with nucleophiles has barely been studied. The main objective of this project deals with a recently discovered Pt-catalysed reaction of bis-allenes with oxygen nucleophiles leading to seven membered cycles with a molecule of the nucleophile incorporated in the final skeleton. This new reaction could involve a double coordination of the Pt atom to both allenes, but the mechanism remains unclear. Recent studies in Dr Muñoz’s group suggest that the Pt, in addition to the more common η2-coordination with the allene, can also appear as a η1-structure, with the Pt atom coordinated to the central carbon of the allene. The discoveries in this field highlight the importance of acquiring knowledge in the bis-allene coordination, since this information could lead to the preparation of more selective catalyst as well as the isolation of reactive intermediates that can be milestones for the construction of new interesting scaffolds. The present project attempts to shed light into the Pt-bis-allene interaction, to exploit the implications of the coordination modes in the reaction mechanisms, and to apply the gained knowledge to the synthesis of new natural-product like structures with potential biological activity.

 Publications

year authors and title journal last update
List of publications.
2020 María Teresa Quirós, Enrique Gómez-Bengoa, María Paz Muñoz
Unravelling mechanistic insights in the platinum-catalysed dihydroalkoxylation of allenes
published pages: 167-177, ISSN: 0033-4545, DOI: 10.1515/pac-2019-0214
Pure and Applied Chemistry 92/1 2020-01-30
2016 José Miguel Alonso, María Teresa Quirós, María Paz Muñoz
Chirality transfer in metal-catalysed intermolecular addition reactions involving allenes
published pages: in press, ISSN: 2052-4129, DOI: 10.1039/C6QO00207B
Org. Chem. Front. 12 issues per year 2019-07-24

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