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OsteoNano

Spatial nanoscale control of growth and adhesion factors to enhance the osteogenic differentiation of mesenchymal stem cells

Total Cost €

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EC-Contrib. €

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Project "OsteoNano" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.lmgp.grenoble-inp.fr/annuaire-/elisa-migliorini--869551.kjsp
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

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 Project objective

In OsteoNano project the training-through-research is targeted at the developing of biomimetic surfaces to study and control the osteogenic differentiation of human Mesenchymal Stem Cells (hMSCs). Osteogenic differentiation of hMSCs can be guided by growth factors, such as bone morphogenetic protein 2 (BMP-2). Currently, recombinantly expressed BMP-2 is applied clinically to enhance the healing of fractured sites. However, the absence of a control over the growth factor surface density and adhesion of cells induce side effects such as ectopic bone formation. The first aim of this project is to present BMP-2 to hMSCs in a spatially controlled manner by applying surface sensitive and high-resolution techniques. The growth factors will be linked to the surface using glycosamminoglycans (GAGs) such as heparan sulphate (HS), and combined with adhesives molecules such as cyclic RGD sequences, which are known to increase the osteogenic effects of BMP-2 by activation of Integrin alphaV-beta3 and alpha5beta1. Our approach will be to design biomimetic surfaces with stepwise increasing complexity, by binding each component in a controlled manner, in terms of orientation, surface density and spatial arrangement. By using these functionalized substrates for hMSCs osteogenic differentiation we will answer several fundamental questions regarding the role of BMP-2 and its interaction with HS and RGD sequences on the osteogenic commitment of hMSCs. The biomimetic surfaces proposed here, present several fundamental studies, advantages and breakthroughs (i) reduced use of BMP-2 bound on the surface: indeed (i) the binding prevents the cellular internalization of the growth factors; (ii) possibility to enhance the osteogenic differentiation by surface co-presentation of BMPs or/and of RGDs; (iii) surface versatility with respect to stiffness which could positively impact osteogenic differentiation.

 Publications

year authors and title journal last update
List of publications.
2016 Elisa Migliorini, Anne Valat, Catherine Picart, Elisabetta Ada Cavalcanti-Adam
Tuning cellular responses to BMP-2 with material surfaces
published pages: 43-54, ISSN: 1359-6101, DOI: 10.1016/j.cytogfr.2015.11.008
Cytokine & Growth Factor Reviews 27 2019-07-24
2017 Elisa Migliorini, Patrick Horn, Tamás Haraszti, Seraphine V. Wegner, Christian Hiepen, Petra Knaus, Ralf P. Richter, Elisabetta Ada Cavalcanti-Adam
Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate
published pages: 1600041, ISSN: 2366-7478, DOI: 10.1002/adbi.201600041
Advanced Biosystems 27 March 2019-07-24

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The information about "OSTEONANO" are provided by the European Opendata Portal: CORDIS opendata.

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