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HAT-MOZ-sphere

Identification of genes and pathways regulated by the HAT activity of MOZ

Total Cost €

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EC-Contrib. €

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Partnership

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 HAT-MOZ-sphere project word cloud

Explore the words cloud of the HAT-MOZ-sphere project. It provides you a very rough idea of what is the project "HAT-MOZ-sphere" about.

transferable    tool    myeloblastic    determined    maintenance    immunoprecipitation    chip    host    supervisor    marrow    followed    regulated    rna    manchester    chromatin    fusion    line    zinc    leukaemogenesis    sequencing    tif2    genes    moz    transferase    cancer    retrovirus    leukaemia    institute    monocytic    polymerase    seq    exceptionally    critical    histone    programs    training    haematopoietic    relying    function    acetyl    variety    obtain    anne    modifications    recruitment    expertise    epigenetic    acute    calibre    skills    genome    mouse    marks    cells    model    haematopoiesis    performed    laboratory    finger    obtaining    understand    silac    murine    bone    player    translocations    multidisciplinary    comprise    dr    largeot    protein    enzymatic    transduction    powerful    encoding    mutated    deletion    loci    survey    competitive    landscape    leadership    leukaemic    crucially    abrogate    technique    position    hat    uk    proteins   

Project "HAT-MOZ-sphere" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
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surname: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.cruk.manchester.ac.uk/Research/CRUK-MI-Groups/Stem-Cell-Biology/Home
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 195˙454.00

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 Project objective

The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system. In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia. Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activity of MOZ. A mouse line specifically mutated to abrogate the HAT enzymatic activity of MOZ has been developed in the host laboratory, and represents a powerful and unique tool for the study of MOZ HAT activity. Using Chromatin ImmunoPrecipitation followed by sequencing (ChIP-seq), genome wide targets of MOZ will be determined and the consequences of the deletion of its HAT activity on the epigenetic landscape will be investigated through the survey of several histone modifications and RNA polymerase II recruitment. The non-histone targets of MOZ will be identified through the SILAC technique. Finally a MOZ murine leukaemic model has been developed, based on the transduction of bone marrow cells with a retrovirus encoding MOZ-TIF2, one of the fusion proteins involving MOZ. ChIP-seq will be performed in these leukaemic cells to identify genes targeted by MOZ-TIF2 and changes in epigenetic marks at these loci. Overall, this project will provide a better understanding of MOZ HAT activity in haematopoiesis and leukaemogenesis. Crucially, this project will enable Dr Anne Largeot to obtain and develop a wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute

 Publications

year authors and title journal last update
List of publications.
2016 Andrew J. Lilly, Guilherme Costa, Anne Largeot, Muhammad Z. H. Fadlullah, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac
published pages: 4341-4351, ISSN: 0950-1991, DOI: 10.1242/dev.140970
Development 143/23 2019-06-14
2016 Anne Largeot, Flor Maria Perez-Campo, Elli Marinopoulou, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
published pages: 231-237.e4, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2015.12.006
Experimental Hematology 44/4 2019-06-14

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