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MediVAC

Bio-sustainable production of natural medicines from Vitex

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "MediVAC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://synbio.ku.dk/researchers/allison_maree_heskes/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Vitex agnus-castus (VAC) is a medicinal plant clinically shown to be an effective treatment for premenstrual syndrome. The bioactive constituents are diterpenoids that can interact with G-protein-coupled receptors such as the dopamine D2 and D3 receptors. This specific activity also opens up the possibility of other therapeutic applications where dopaminergic drugs are required, such as for the treatment of Parkinson’s disease and other movement disorders. The major barrier to the development of VAC diterpenoid drugs, and the further exploration of pharmacological activity of VAC diterpenoids, is the lack of a source of pure compounds. MediVAC is a 24 month research project that will discover the genes involved in the biosynthesis of pharmacologically active diterpenoids in VAC, and to express these genes in a biotechnological platform for the sustainable production of pure bioactive diterpenoids. State-of-the-art imaging mass spectrometry tools will be used to identify diterpenoid rich tissues which will be targeted for transcriptomics. Then, through the integration of bioinformatic, molecular biology and analytical chemistry techniques, the diterpene synthases and cytochrome P450 enzymes involved in VAC diterpenoid biosynthesis will be identified and functionally characterised. The resulting molecular toolbox of diterpenoid genes will be stably integrated into yeast for the production of bioactive diterpenoids. The engineered host strains hold potential for the future development of an industrial scale production platform able to produce high-purity, bioactive diterpenoids for the pharmaceutical industry. Implementation of this proposal will provide the research fellow with essential training in the field of molecular biology and further her plant metabolic profiling expertise, leaving her with a unique and highly sought after skill set.

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The information about "MEDIVAC" are provided by the European Opendata Portal: CORDIS opendata.

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