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ImmunoFarm

IgA-based oral therapy for protection of piglets against infection with enterotoxigenic E. coli.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmunoFarm project word cloud

Explore the words cloud of the ImmunoFarm project. It provides you a very rough idea of what is the project "ImmunoFarm" about.

mucosal    strains    elite    vhhs    nicotiana    transferred    format    performed    rearing    prolong    surfaces    soya    host    global    expression    world    receiving    antibiotics    bulk    infections    prophylactic    benthamiana    formulation    pwd    economic    rest    strategy    immunotherapy    resistance    pig    vivo    responsible    platform    thaliana    fight    seed    passive    forbidden    groups    except    transient    diarrhoea    fimbriae    transformants    f18    lactogenic    feed    cocktails    regular    abundance    postweaning    caused    domains    neutralisation    treatment    coli    industry    f4    formulations    etec    adhesion    pigs    seeds    maternal    display    negative    losses    piglets    twenty    antibody    illness    post    vitro    arabidopsis    siga    weaning    additive    scalable    phage    villus    first    effect    assays    synergistic    immunity    anti    prophylaxis    oligoclonal    genes    agent    enterotoxigenic    antibodies    predominantly    engineered    biosafe    obtain    group   

Project "ImmunoFarm" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.facebook.com/ImmunoFarm-356855711413541/
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-08-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Postweaning diarrhoea (PWD) in pigs is responsible for important economic losses in the global pig rearing industry. This illness is predominantly caused by enterotoxigenic E. coli strains carrying the F4 (ETEC-F4) and F18 (ETEC-F18) fimbriae. There is no treatment available to fight PWD except using antibiotics. However, the prophylactic use of antibiotics is forbidden in Europe and is expected to become forbidden in the rest of the world because of increasing abundance of resistance genes. Delivery of sIgA to mucosal surfaces as passive immunotherapy agent is a very promising strategy to prolong maternal lactogenic immunity against post-weaning infections. The aim of this project is to produce sIgA-like anti-ETEC antibodies in a cost-effective platform. Twenty different anti ETEC-F18 antibodies in a sIgA-like format will be engineered from phage display-selected variable domains (VHHs) currently available in the host institute. The synergistic or additive neutralisation effect of oligoclonal antibody cocktails will be evaluated using ETEC-F18 in vitro villus adhesion assays. The different antibodies will be produced first by transient expression in Nicotiana benthamiana and second in seeds of Arabidopsis thaliana transformants. An in vivo ETEC-F18 challenge will then be performed using two groups of piglets, one receiving the most effective seed-derived feed formulations and the other one receiving regular feed (negative control group). The sIgA antibodies of the elite oligoclonal formulation will then be transferred to biosafe soya seeds as production platform. These steps will lead towards the development of scalable procedures to obtain a cost effective bulk production of a feed based prophylaxis against ETEC.

 Publications

year authors and title journal last update
List of publications.
2016 Vikram Virdi, Paloma Juarez, Veronique Boudolf, Ann Depicker
Recombinant IgA production for mucosal passive immunization, advancing beyond the hurdles
published pages: 535-545, ISSN: 1420-682X, DOI: 10.1007/s00018-015-2074-0
Cellular and Molecular Life Sciences 73/3 2019-07-24
2016 Paloma Juarez, Vikram Virdi, Ann Depicker, Diego Orzaez
Biomanufacturing of protective antibodies and other therapeutics in edible plant tissues for oral applications
published pages: n/a-n/a, ISSN: 1467-7644, DOI: 10.1111/pbi.12541
Plant Biotechnology Journal 2019-07-24

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The information about "IMMUNOFARM" are provided by the European Opendata Portal: CORDIS opendata.

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