EU H2020 Project "MYO-DESMOPLASIA (Modulating the behaviour of cancer myofibroblasts to control tumour..)": description, partecipants, costs and EC-fundings

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MYO-DESMOPLASIA project word cloud

Explore the words cloud of the MYO-DESMOPLASIA project. It provides you a very rough idea of what is the project "MYO-DESMOPLASIA" about.

desmoplasia absence scientific light expression international alterations physiology nano solid subsequently progression morphodynamic inter microscopy cutting modulating agents barrier atomic genes complementary reduce encoding mechanisms pattern tumor elucidate model patients force determines professional acquire personalized behavior mechanical interplay sectoral topography tumors patho extensive hypothesis mobility anti plan fibroblasts combination time career ecm stiffness determined employed survival fluorescence concentrations alone transforming proposes position extracellular poses desmoplastic tunable beta activation pcr drug additive components form maturity edge fellow myofibroblasts reaction explore tgf stromal cancer cells mainly techniques takes collagen training skills cultured place models matrix

Project "MYO-DESMOPLASIA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF CYPRUS Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 website: www.ucy.ac.cy contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Cyprus [CY]
Project website	http://www.ucy.ac.cy/cancer_biophysics/en/myodesmoplasia
Total cost	163˙648 €
EC max contribution	163˙648 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2017-05-31

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF CYPRUS	CY (NICOSIA)	coordinator	163˙648.00

UNIVERSITY OF CYPRUS

CY (NICOSIA)

coordinator

163˙648.00

Project objective

In many tumors a desmoplastic reaction takes place during progression, which results in extensive production of collagen by stromal cells of the tumor, mainly fibroblasts and myofibroblasts. Tumor desmoplasia determines in large part the patho-physiology of solid tumors and poses a major barrier to effective drug delivery, affecting the overall survival of cancer patients. Here, the applicant proposes to test the hypothesis that the increase in extracellular matrix (ECM) stiffness and transforming growth factor-beta (TGFβ) activation often observed during tumor progression have additive effects on tumor desmoplasia. Therefore, targeting any of these parameters alone or in combination can reduce the desmoplastic response of the stromal cells. To explore this hypothesis, a combination of cutting-edge techniques will be employed. Specifically, a collagen ECM model, with pre-determined topography and tunable stiffness will be developed. Subsequently, fibroblasts and myofibroblasts will be cultured in the ECM models. Cells nano-mechanical behavior and their morphodynamic alterations will be investigated with Atomic Force Microscopy and light/fluorescence microscopy under the presence or absence of TGFβ or anti-TGFβ agents. Finally, the effects of matrix stiffness along with different TGFβ concentrations in the expression pattern of genes encoding ECM components will be investigated using real-time PCR. The research results will elucidate the mechanisms of the interplay between matrix stiffness and TGFβ production in modulating the ability of fibroblasts and myofibroblasts to form tumor desmoplasia. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and inter-sectoral mobility will reach a position of professional maturity in research.

Publications

List of publications.
year	authors and title	journal	last update
2017	Andreas Stylianou Atomic Force Microscopy for Collagen-Based Nanobiomaterials published pages: 1-14, ISSN: 1687-4110, DOI: 10.1155/2017/9234627	Journal of Nanomaterials 2017	2019-06-14
2016	Andreas Stylianou, Triantafyllos Stylianopoulos Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components published pages: 33-46, ISSN: 2191-1630, DOI: 10.1007/s12668-015-0187-4	BioNanoScience 6/1	2019-06-14
2017	S V Kontomaris, A Stylianou Atomic force microscopy for university students: applications in biomaterials published pages: 33003, ISSN: 0143-0807, DOI: 10.1088/1361-6404/aa5cd6	European Journal of Physics 38/3	2019-06-14

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