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PhotoXLink SIGNED

Development of biomolecular tools for the spatiotemporal photocontrol of AMPA receptors mobility

Total Cost €

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EC-Contrib. €

0

Partnership

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 PhotoXLink project word cloud

Explore the words cloud of the PhotoXLink project. It provides you a very rough idea of what is the project "PhotoXLink" about.

training    combined    forms    fulfil    host    ampar    underlies    mediated    oligomeric    receptor    plasticity    local    line    locally    validating    unprecedented    resolution    photobiology    successfully    nature    multidisciplinary    memory    internationally    brain    limitations    chance    acute    reversible    hence    temporal    diversify    elucidate    biology    situations    expertise    synaptic    photochemistry    mediates    spatial    photocrosslinkers    fluorescence    career    protein    recognize    ensures    research    imaging    molecular    fast    regulation    techniques    neurobiology    skills    engineer    goals    pathological    engineering    subunits    acutely    ionotropic    excitatory    cellular    neuroscience    cell    nervous    transmembrane    molecule    ampars    function    tools    quality    original    glutamate    spatiotemporal    context    learning    photoxlink    ultimately    physiological    individual    theories    central    mammalian    ampa    biochemistry    competences    transmission    mobility    optogenetic    manner    vital   

Project "PhotoXLink" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 184˙707.00

Map

 Project objective

The PhotoXLink project aims to develop original tools to elucidate the role of various AMPA receptor mediated forms of plasticity in both physiological and pathological situations. AMPAR is a transmembrane ionotropic receptor for glutamate molecule that mediates most fast excitatory synaptic transmission in the mammalian central nervous system. Its regulation is vital for their synaptic function, which underlies memory and learning theories. In the PhotoXLink project, we propose to engineer novel optogenetic tools (photocrosslinkers) that will specifically recognize AMPAR subunits and control their oligomeric state with spatial and temporal resolution. The photocrosslinkers will hence provide a unique control locally, acutely and in a reversible manner on the mobility and local number of AMPARs. The development of these photocrosslinkers will address current technical limitations and ultimately allow investigating with an unprecedented spatiotemporal resolution the impact of AMPARs mobility in short and long term plasticity in the brain function. The multidisciplinary nature of the project is strong, involving molecular/cell biology, biochemistry and protein engineering for the design and production of the tools and advanced fluorescence imaging techniques for validating them in cellular context. It will be carried out at an internationally recognized neuroscience institute that will enhance my skills and diversify my individual competences through advanced training and quality research for improving my future career development. My expertise in photochemistry and photobiology combined with the host´s in neurobiology and protein engineering ensures the best chance for successfully fulfil the goals of the PhotoXLink project. This project is in line with the brain research priority for EU research funding.

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The information about "PHOTOXLINK" are provided by the European Opendata Portal: CORDIS opendata.

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