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PhotoXLink SIGNED

Development of biomolecular tools for the spatiotemporal photocontrol of AMPA receptors mobility

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PhotoXLink project word cloud

Explore the words cloud of the PhotoXLink project. It provides you a very rough idea of what is the project "PhotoXLink" about.

nature    molecule    reversible    molecular    resolution    ampa    transmission    photoxlink    line    receptor    learning    ionotropic    mammalian    skills    ensures    physiological    engineer    mobility    chance    fast    optogenetic    individual    brain    synaptic    expertise    spatial    oligomeric    techniques    elucidate    ampars    temporal    spatiotemporal    subunits    regulation    vital    biology    competences    excitatory    cell    biochemistry    manner    successfully    original    neurobiology    neuroscience    locally    acutely    cellular    fluorescence    context    glutamate    local    nervous    protein    validating    acute    internationally    host    pathological    goals    hence    memory    training    underlies    fulfil    function    photochemistry    transmembrane    combined    forms    ultimately    photobiology    recognize    plasticity    career    research    photocrosslinkers    central    multidisciplinary    diversify    limitations    quality    mediated    engineering    tools    unprecedented    imaging    mediates    theories    situations    ampar   

Project "PhotoXLink" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 184˙707.00

Map

 Project objective

The PhotoXLink project aims to develop original tools to elucidate the role of various AMPA receptor mediated forms of plasticity in both physiological and pathological situations. AMPAR is a transmembrane ionotropic receptor for glutamate molecule that mediates most fast excitatory synaptic transmission in the mammalian central nervous system. Its regulation is vital for their synaptic function, which underlies memory and learning theories. In the PhotoXLink project, we propose to engineer novel optogenetic tools (photocrosslinkers) that will specifically recognize AMPAR subunits and control their oligomeric state with spatial and temporal resolution. The photocrosslinkers will hence provide a unique control locally, acutely and in a reversible manner on the mobility and local number of AMPARs. The development of these photocrosslinkers will address current technical limitations and ultimately allow investigating with an unprecedented spatiotemporal resolution the impact of AMPARs mobility in short and long term plasticity in the brain function. The multidisciplinary nature of the project is strong, involving molecular/cell biology, biochemistry and protein engineering for the design and production of the tools and advanced fluorescence imaging techniques for validating them in cellular context. It will be carried out at an internationally recognized neuroscience institute that will enhance my skills and diversify my individual competences through advanced training and quality research for improving my future career development. My expertise in photochemistry and photobiology combined with the host´s in neurobiology and protein engineering ensures the best chance for successfully fulfil the goals of the PhotoXLink project. This project is in line with the brain research priority for EU research funding.

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The information about "PHOTOXLINK" are provided by the European Opendata Portal: CORDIS opendata.

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