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PhotoXLink SIGNED

Development of biomolecular tools for the spatiotemporal photocontrol of AMPA receptors mobility

Total Cost €

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EC-Contrib. €

0

Partnership

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 PhotoXLink project word cloud

Explore the words cloud of the PhotoXLink project. It provides you a very rough idea of what is the project "PhotoXLink" about.

elucidate    techniques    goals    cellular    quality    internationally    physiological    reversible    locally    fluorescence    limitations    mammalian    temporal    host    engineer    forms    successfully    ampar    plasticity    expertise    regulation    function    validating    ampars    original    underlies    diversify    resolution    molecule    training    oligomeric    subunits    context    local    glutamate    mediated    hence    receptor    fulfil    nature    ensures    cell    theories    pathological    mediates    chance    line    ampa    photochemistry    imaging    spatial    photoxlink    unprecedented    transmission    memory    acute    mobility    acutely    molecular    nervous    transmembrane    ultimately    central    recognize    brain    biochemistry    situations    biology    multidisciplinary    engineering    protein    research    fast    neurobiology    learning    manner    ionotropic    spatiotemporal    neuroscience    vital    synaptic    combined    excitatory    photocrosslinkers    individual    tools    competences    career    skills    optogenetic    photobiology   

Project "PhotoXLink" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 184˙707.00

Map

 Project objective

The PhotoXLink project aims to develop original tools to elucidate the role of various AMPA receptor mediated forms of plasticity in both physiological and pathological situations. AMPAR is a transmembrane ionotropic receptor for glutamate molecule that mediates most fast excitatory synaptic transmission in the mammalian central nervous system. Its regulation is vital for their synaptic function, which underlies memory and learning theories. In the PhotoXLink project, we propose to engineer novel optogenetic tools (photocrosslinkers) that will specifically recognize AMPAR subunits and control their oligomeric state with spatial and temporal resolution. The photocrosslinkers will hence provide a unique control locally, acutely and in a reversible manner on the mobility and local number of AMPARs. The development of these photocrosslinkers will address current technical limitations and ultimately allow investigating with an unprecedented spatiotemporal resolution the impact of AMPARs mobility in short and long term plasticity in the brain function. The multidisciplinary nature of the project is strong, involving molecular/cell biology, biochemistry and protein engineering for the design and production of the tools and advanced fluorescence imaging techniques for validating them in cellular context. It will be carried out at an internationally recognized neuroscience institute that will enhance my skills and diversify my individual competences through advanced training and quality research for improving my future career development. My expertise in photochemistry and photobiology combined with the host´s in neurobiology and protein engineering ensures the best chance for successfully fulfil the goals of the PhotoXLink project. This project is in line with the brain research priority for EU research funding.

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The information about "PHOTOXLINK" are provided by the European Opendata Portal: CORDIS opendata.

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