Opendata, web and dolomites

STOP-Beta

Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 STOP-Beta project word cloud

Explore the words cloud of the STOP-Beta project. It provides you a very rough idea of what is the project "STOP-Beta" about.

suppression    heavily    oxford    physiological    rhythm    offers    beta    technological    brown    disabling    firing    selectively    electrical    motor    human    researcher    electrodes    13    causal    obtain    adjust    group    signals    treatment    world    ongoing    leaving    brain    whilst    headed    neurology    interrupt    neural    disorder    nucleus    disease    synchronous    hypothesis    pathological    connectivity    normal    stimulation    neurological    selective    quality    university    innovative    laboratory    function    render    movements    intriguing    parkinson    implanted    hz    clinical    peter    record    seated    abnormal    deep    experimental    dbs    unaltered    neurons    perform    read    avoiding    conduct    shown    preservation    benefit    functions    stn    send    surface    simultaneously    prof    frequent    significantly    possibility    closed    receiving    probing    subthalamic    patients    impairment    revealing    mechanisms    region    suppress    localized    loop    impairs    life   

Project "STOP-Beta" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.mrcbndu.ox.ac.uk/people/dr-damian-m-herz
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.

 Publications

year authors and title journal last update
List of publications.
2017 Damian M Herz, Huiling Tan, John-Stuart Brittain, Petra Fischer, Binith Cheeran, Alexander L Green, James FitzGerald, Tipu Z Aziz, Keyoumars Ashkan, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Rafal Bogacz, Peter Brown
Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.21481
eLife 6 2019-07-23
2016 Damian M. Herz, Baltazar A. Zavala, Rafal Bogacz, Peter Brown
Neural Correlates of Decision Thresholds in the Human Subthalamic Nucleus
published pages: 916-920, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.01.051
Current Biology 26/7 2019-07-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STOP-BETA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STOP-BETA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More