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STOP-Beta

Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

STOP-Beta project word cloud

Explore the words cloud of the STOP-Beta project. It provides you a very rough idea of what is the project "STOP-Beta" about.

normal neurological clinical deep laboratory interrupt send obtain rhythm connectivity leaving treatment perform localized record ongoing function whilst frequent innovative closed parkinson quality impairs probing neural surface read university group dbs disorder technological firing avoiding causal revealing beta synchronous world motor peter signals neurons functions brown adjust seated loop movements pathological suppress implanted hz 13 intriguing possibility abnormal nucleus electrical unaltered researcher disease preservation suppression render subthalamic human patients oxford shown significantly neurology heavily simultaneously impairment headed disabling hypothesis benefit conduct stimulation prof life brain mechanisms experimental physiological region electrodes receiving stn offers selectively selective

Project "STOP-Beta" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.mrcbndu.ox.ac.uk/people/dr-damian-m-herz
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2017-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	coordinator	183˙454.00

Map

Project objective

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.

Publications

List of publications.
year	authors and title	journal	last update
2017	Damian M Herz, Huiling Tan, John-Stuart Brittain, Petra Fischer, Binith Cheeran, Alexander L Green, James FitzGerald, Tipu Z Aziz, Keyoumars Ashkan, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Rafal Bogacz, Peter Brown Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.21481	eLife 6	2019-07-23
2016	DamianÂ M. Herz, BaltazarÂ A. Zavala, Rafal Bogacz, Peter Brown Neural Correlates of Decision Thresholds in the Human Subthalamic Nucleus published pages: 916-920, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.01.051	Current Biology 26/7	2019-07-23

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