Explore the words cloud of the STOP-Beta project. It provides you a very rough idea of what is the project "STOP-Beta" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-05-01 to 2017-04-30|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||183˙454.00|
Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.
|year||authors and title||journal||last update|
Damian M Herz, Huiling Tan, John-Stuart Brittain, Petra Fischer, Binith Cheeran, Alexander L Green, James FitzGerald, Tipu Z Aziz, Keyoumars Ashkan, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Rafal Bogacz, Peter Brown
Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.21481
DamianÂ M. Herz, BaltazarÂ A. Zavala, Rafal Bogacz, Peter Brown
Neural Correlates of Decision Thresholds in the Human Subthalamic Nucleus
published pages: 916-920, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.01.051
|Current Biology 26/7||2019-07-23|
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