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Atrial Fibrillation, Fibrosis and Rotors: New Insights from Imaging and Computational Modeling

Total Cost €


EC-Contrib. €






 AFIBROTIC project word cloud

Explore the words cloud of the AFIBROTIC project. It provides you a very rough idea of what is the project "AFIBROTIC" about.

personalized    amount    atrium    debated    af    transfer    pathophysiology    incompletely    rotors    fibrillation    patient    fibrosis    framework    computational    benefit    grant    patients    experimental    rigorous    imaging    connecting    medical    mortality    connection    reentries    data    sustain    dependent    relationship    basis    ablation    arrhythmia    solid    electrophysiology    principally    showing    modeling    initiate    promise    maintained    planning    responsiveness    outcomes    instrumentation    fibrillating    career    morbidity    engineering    explaining    catheter    tool    electrical    interventional    synergy    unfortunately    host    causes    expertise    suppression    rates    deprives    implied    nonetheless    improves    correlates    first    clinical    substantial    complementary    treatment    silico    fundaments    vivo    lack    mechanistic    biomedical    model    environment    acquired    measured    mechanisms    atrial    network    enlarged    procedure    operator   

Project "AFIBROTIC" data sheet

The following table provides information about the project.


Organization address
address: VIA ZAMBONI 33
postcode: 40126

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Atrial fibrillation (AF) is the most common type of arrhythmia and causes substantial morbidity and mortality. AF is principally treated with catheter ablation. Unfortunately, the mechanisms that initiate and sustain the arrhythmia are still incompletely understood and, as such, ablation remains a highly operator-dependent procedure with low success rates. Two recent studies promise to lead to better ablation outcomes, showing that a) the amount of atrial fibrosis directly correlates with the non-responsiveness to ablation and that b) AF is maintained by electrical rotors and targeting their suppression improves the success rates. Nonetheless, the lack of a rigorous mechanistic framework of AF pathophysiology deprives those studies of solid fundaments so that their effective value is still debated.

This project aims therefore to provide such a framework by exploiting advanced biomedical engineering concepts. The focus will be on explaining and connecting recent experimental findings about fibrosis and rotors. The relationship will be first analyzed in vivo from AF patient data acquired with state-of-the-art instrumentation in the field of interventional electrophysiology. Measured data will be then integrated within a multi-scale personalized computational model of the fibrillating atrium that will determine, on a patient-specific basis, the mechanistic connection between fibrosis and reentries. Furthermore, the tool will provide an in silico environment for personalized ablation planning. Key in the project will be the synergy between complementary state-of-the-art expertise in the fields of medical imaging and computational modeling provided by applicant and host institutions. All partners will strongly benefit from the implied two way knowledge transfer, in terms of career advancement (the applicant) and enlarged network/grant proposal opportunities. The study will foster more focused clinical research aiming at better treatment for the AF patients.


year authors and title journal last update
List of publications.
2017 Maddalena Valinoti, Francesca Berto, Martino Alessandrini, Roberto Mantovan, Axel Loewe, Olaf Doessel, Stefano Severi, Cristiana Corsi
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation,
published pages: , ISSN: , DOI:
Computing in Cardiology, Rennes, FR 2019-06-17
2017 Masci A, Martino Alessandrini, Davide Forti, Filippo Menghini, Luca Dedé, Corrado Tommasi, Alfio Quarteroni, and Cristiana Corsi
A Patient-Specific Computational FluidDynamics Model of the Left Atrium in AtrialFibrillation: Development and Initial Evaluation
published pages: , ISSN: , DOI:
Proc. of Functional Imaging and Modeling of the Heart (FIMH), Toronto, CA 2019-06-17
2018 Claudio Fabbri, Maddalena Valinoti, Cristiana Corsi, Martino Alessandrini
Segmentation of cardiac structures
published pages: , ISSN: , DOI:
Cardiovascular Computing: Methodologies and Clinical Applications. Editors: Spyretta Golemati and Konstantina S. Nikita 2019-06-17
2017 Carolina Vallecilla, Martino Alessandrini, Claudio Fabbri, Corrado Tomasi, Cristiana Corsi, Stefano Severi
Preliminary Computational Framework to Map MRI Derived Markers to Predict Response to Cardiac Resynchronization Therapy
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17
2017 Martino Alessandrini, Maddalena Valinoti, Axel Loewe, Tobias Oesterlein, Olaf Doessel, Cristiana Corsi, Stefano Severi
A Computational Framework to Benchmark Basket Catheter Guided Ablation (IN PRESS)
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17
2016 M. Alessandrini, M. Valinoti, A. Pasini, R. Mantovan, S. Severi and C. Corsi
An automatic framework for the non-rigid alignment of electroanatomical maps and preoperative anatomical scans in atrial fibrillation
published pages: , ISSN: , DOI:
Proc. of Computing in Cardiology 2016, Vancouver, CA 2019-06-17
2018 M. Alessandrini
Combined techniques of filtering and speckle tracking
published pages: , ISSN: , DOI:
Handbook of Speckle Filtering and Tracking in Cardiovascular Ultrasound Imaging and Video. Editors: Christos Loizou, Constantinos Pattichis and Jan D’hooge 2019-06-17
2018 Martino Alessandrini, B. Chakraborty, B. Heyde, O. Bernard, M. De Craene, M Sermesant, J. D’hooge
Realistic Vendor Specific Sythetic Ultrasound Data for Quality Assurance of 2D Speckle Tracking Echocardiography: Simulation pipeline and Open Access Database. ACCEPTED FOR PUBLICATION.
published pages: , ISSN: 0885-3010, DOI:
IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2019-06-17
2017 Alessandro Masci, Martino Alessandrini, Luca Dedè, Davide, Forti, Filippo Menghini, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
Development of a Computational Fluid Dynamics Model of the Left Atrium in Atrial Fibrillation on a Patient Specific Basis
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17

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