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URBANEPIGENETICS

The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress

Total Cost €

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EC-Contrib. €

0

Partnership

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 URBANEPIGENETICS project word cloud

Explore the words cloud of the URBANEPIGENETICS project. It provides you a very rough idea of what is the project "URBANEPIGENETICS" about.

global    date    direct    thereby    disease    profound    wildlife    mechanistically    stressors    linked    skills    relationships    alters    modification    gene    humans    attrition    combining    pilot    mechanism    career    phenotypic    shown    exposure    genes    dynamics    methylation    telomere    genome    length    wild    first    epigenetic    fitness    disentangle    urban    environmental    pollutant    stability    framework    urbanisation    damage    bird    later    basis    antioxidant    stress    lab    developmental    prospects    oxidative    experimental    modifications    ageing    resistance    multiple    altricial    pollutants    researcher    modify    stages    outlines    mechanisms    perform    influencing    birds    mediating    performance    species    indirect    exposed    expertise    decoupled    life    link    survival    influenced    populations    mechanistic    implications    policies    patterns    examine    dna    multidisciplinary    cues    modifies    rural    data    epigenome    expression   

Project "URBANEPIGENETICS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.biology.lu.se/hannah-watson
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researcher’s existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.

 Publications

year authors and title journal last update
List of publications.
2017 Hannah Watson, Elin Videvall, Martin N. Andersson, Caroline Isaksson
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
published pages: 44180, ISSN: 2045-2322, DOI: 10.1038/srep44180
Scientific Reports 7 2019-07-22

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