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URBANEPIGENETICS

The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 URBANEPIGENETICS project word cloud

Explore the words cloud of the URBANEPIGENETICS project. It provides you a very rough idea of what is the project "URBANEPIGENETICS" about.

stress    modifies    mechanisms    performance    later    influencing    dynamics    expertise    stages    basis    direct    career    pilot    global    developmental    combining    pollutant    profound    disease    wildlife    birds    exposed    mechanism    mechanistic    multidisciplinary    relationships    modifications    genome    ageing    cues    implications    wild    influenced    damage    urban    exposure    prospects    oxidative    attrition    policies    shown    skills    altricial    alters    epigenome    examine    methylation    bird    fitness    patterns    expression    data    perform    antioxidant    modify    species    linked    date    life    rural    indirect    dna    pollutants    telomere    thereby    epigenetic    resistance    environmental    humans    stressors    populations    survival    gene    mechanistically    stability    outlines    length    disentangle    modification    framework    link    researcher    phenotypic    decoupled    lab    urbanisation    experimental    multiple    first    genes    mediating   

Project "URBANEPIGENETICS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.biology.lu.se/hannah-watson
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researcher’s existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.

 Publications

year authors and title journal last update
List of publications.
2017 Hannah Watson, Elin Videvall, Martin N. Andersson, Caroline Isaksson
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
published pages: 44180, ISSN: 2045-2322, DOI: 10.1038/srep44180
Scientific Reports 7 2019-07-22

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