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URBANEPIGENETICS

The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress

Total Cost €

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EC-Contrib. €

0

Partnership

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 URBANEPIGENETICS project word cloud

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dynamics    disease    resistance    stability    researcher    disentangle    combining    link    decoupled    populations    ageing    implications    patterns    genes    bird    direct    thereby    fitness    survival    cues    date    performance    influencing    environmental    experimental    outlines    wildlife    antioxidant    life    skills    framework    lab    alters    multiple    dna    urbanisation    species    altricial    relationships    prospects    length    attrition    modifications    career    global    pollutants    expertise    wild    data    policies    influenced    humans    examine    genome    profound    mechanisms    pilot    perform    mechanistic    pollutant    developmental    phenotypic    multidisciplinary    epigenetic    rural    basis    mechanism    modify    mediating    methylation    modifies    modification    birds    mechanistically    gene    later    urban    oxidative    telomere    shown    expression    stress    first    linked    exposed    damage    stressors    stages    indirect    epigenome    exposure   

Project "URBANEPIGENETICS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.biology.lu.se/hannah-watson
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researcher’s existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.

 Publications

year authors and title journal last update
List of publications.
2017 Hannah Watson, Elin Videvall, Martin N. Andersson, Caroline Isaksson
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
published pages: 44180, ISSN: 2045-2322, DOI: 10.1038/srep44180
Scientific Reports 7 2019-07-22

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