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The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress

Total Cost €


EC-Contrib. €






 URBANEPIGENETICS project word cloud

Explore the words cloud of the URBANEPIGENETICS project. It provides you a very rough idea of what is the project "URBANEPIGENETICS" about.

genes    attrition    skills    shown    dynamics    later    mediating    indirect    pilot    stressors    telomere    mechanisms    wildlife    birds    stages    decoupled    exposure    developmental    wild    implications    link    populations    multidisciplinary    fitness    alters    expertise    altricial    dna    data    direct    disease    influencing    genome    humans    profound    ageing    modifications    mechanism    modification    cues    resistance    pollutant    stress    researcher    mechanistic    framework    disentangle    antioxidant    urbanisation    mechanistically    survival    expression    lab    pollutants    bird    performance    rural    date    life    stability    influenced    damage    linked    global    outlines    phenotypic    career    combining    perform    first    multiple    experimental    policies    prospects    methylation    patterns    epigenome    modifies    gene    urban    length    exposed    examine    epigenetic    relationships    species    thereby    modify    basis    environmental    oxidative   

Project "URBANEPIGENETICS" data sheet

The following table provides information about the project.


Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00


 Project objective

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researcher’s existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.


year authors and title journal last update
List of publications.
2017 Hannah Watson, Elin Videvall, Martin N. Andersson, Caroline Isaksson
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
published pages: 44180, ISSN: 2045-2322, DOI: 10.1038/srep44180
Scientific Reports 7 2019-07-22

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The information about "URBANEPIGENETICS" are provided by the European Opendata Portal: CORDIS opendata.

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