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URBANEPIGENETICS

The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 URBANEPIGENETICS project word cloud

Explore the words cloud of the URBANEPIGENETICS project. It provides you a very rough idea of what is the project "URBANEPIGENETICS" about.

combining    profound    researcher    telomere    rural    genome    fitness    stress    populations    examine    global    species    lab    influencing    exposure    policies    expression    influenced    phenotypic    implications    stressors    mechanism    multiple    performance    mediating    indirect    survival    urban    humans    gene    skills    pollutant    wild    developmental    first    oxidative    pilot    alters    modifications    urbanisation    dynamics    later    life    dna    prospects    exposed    ageing    length    methylation    framework    career    modify    outlines    direct    shown    altricial    environmental    decoupled    epigenome    multidisciplinary    link    basis    linked    pollutants    birds    patterns    relationships    attrition    epigenetic    damage    date    expertise    mechanisms    mechanistically    modifies    bird    stages    cues    experimental    data    thereby    stability    modification    wildlife    antioxidant    perform    disease    genes    resistance    mechanistic    disentangle   

Project "URBANEPIGENETICS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.biology.lu.se/hannah-watson
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 185˙857.00

Map

 Project objective

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researcher’s existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.

 Publications

year authors and title journal last update
List of publications.
2017 Hannah Watson, Elin Videvall, Martin N. Andersson, Caroline Isaksson
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
published pages: 44180, ISSN: 2045-2322, DOI: 10.1038/srep44180
Scientific Reports 7 2019-07-22

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