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FiBRO SIGNED

Fibroblasts in the Biology of Rectal Cancer Progression

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FiBRO" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://science.institut-curie.org/research/multiscale-physics-biology-chemistry/umr144-subcellular-structure-and-cellular-dynamics/team-vignjevic/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 173˙076.00

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 Project objective

Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patient’s quality of life, tumor relapse still constitutes to be a factor that determines patient survival. These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas. The importance of tumor stroma for the development, progression and invasion of cancer is increasingly gaining weight, however, the biological basis of fibrosis, as well as the consequences that it has in terms of therapy resistance and tumor relapse remain unknown. The major objective of this proposal is to understand the effect of CRT on fibroblasts and its consequences on tumor relapse and formation of distant metastasis. To reach this, we propose a multidisciplinary approach that combines the analysis of unique patient-derived biological samples using innovative and advanced techniques in molecular and cell biology. More specifically, using a proteomic approach and primary cultures of fibroblasts derived from rectal tumors taken before and after CRT from the same patient, we will determine the effect of CRT on the molecular alterations in fibroblasts. Then, using 3D in vitro models we will determine if CRT-derived fibroblasts play a role in therapy resistance, proliferation and invasion of cancer cells, while ortothopic mouse models will be used to test if CRT-derived fibroblasts can trigger rectal cancer progression and metastasis. Finally, using previously collected clinical data of rectal cancer patients we will analyze if tumor relapse is related to the appearance of fibrosis and, if it has a positive or negative prognosis value Altogether, the results expected from this project will improve basic biological knowledge of fibrosis-development, and will provide with new clinical tools to improve patient welfare.

 Publications

year authors and title journal last update
List of publications.
2017 Jorge Barbazán, Lorena Alonso-Alconada, Nadia Elkhatib, Sara Geraldo, Vasily Gurchenkov, Alexandros Glentis, Guillaume van Niel, Roberta Palmulli, Beatriz Fernández, Patricia Viaño, Tomas Garcia-Caballero, Rafael López-López, Miguel Abal, Danijela Matic Vignjevic
Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
published pages: 3431-3441, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-1917
Cancer Research 77/13 2019-06-18
2018 Ralitza Staneva, Jorge Barbazan, Anthony Simon, Danijela Matic Vignjevic, Denis Krndija
Cell Migration in Tissues: Explant Culture and Live Imaging
published pages: 163-173, ISSN: , DOI: 10.1007/978-1-4939-7701-7_13
Methods in Molecular Biology 2019-06-18

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