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ISPADMEC

Integrin specificity in rigidity sensitive proliferation, activation and directional migration of endothelial cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ISPADMEC project word cloud

Explore the words cloud of the ISPADMEC project. It provides you a very rough idea of what is the project "ISPADMEC" about.

recognize    spreading    tissue    expression    answers    interdisciplinary    materials    extraordinary    malformation    engagement    extracellular    selective    regulated    mechanical    signals    nanometer    precise    science    morphology    players    precision    chemical    tunable    abnormal    tools    ecm    ecs    regulate    blood    mechanisms    adhesion    sense    presentation    microenvironment    protein    endothelial    light    deregulated    structural    length    encoded    cells    contractility    substrate    functions    healthy    healing    modulate    matrix    tension    directional    biochemical    adhesions    wound    viscoelasticity    fundamental    pathological    integrin    pressing    intricately    biology    vessel    atherosclerosis    micrometer    nanotechnology    isolate    activation    shed    migration    function    vitro    mechanics    regulation    questions    fate    strategy    cell    minimal    anticipated    summary    proliferation    scenarios    ligands    transduce    unmet    ec    unsurprisingly    physical    diversity    tumor    cues    substrates    scales    topographical    extracelullar    correlate    disease    contribution   

Project "ISPADMEC" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2018-06-26

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Cells have the extraordinary ability to regulate their morphology, functions and fate to minimal changes in the extracelullar microenvironment. Through multi-protein, cell-matrix adhesions they are able to recognize and respond not only to the chemical diversity of the extracellular matrix (ECM), but also to its physical and topographical features. Mechanical and structural cues encoded in the ECM have an essential role in healthy tissue function where contractility, spreading and proliferation are intricately regulated by cell-cell and cell-matrix adhesion and tension. Unsurprisingly, abnormal ECM mechanics are directly associated with disease and tissue malformation (atherosclerosis, wound healing and tumor formation). Understanding the mechanisms cells use to sense and transduce mechanical signals, as well as the contribution of key players in the process is a pressing, unmet challenge. To achieve this goal, I here propose the development of an in vitro strategy that allows precise regulation of both biochemical and mechanical parameters in order to isolate their contribution on fundamental endothelial cell (EC) functions. The proposed work will exploit advances in materials science and nanotechnology to modulate with high precision the presentation of highly selective integrin ligands at the nanometer and micrometer length scales, on substrates with tunable viscoelasticity and mechanics. The anticipated effects of integrin engagement and substrate mechanics on ECs will shed light on how the microenvironment affects their proliferation, activation and directional migration, and help correlate these finding with pathological scenarios where blood vessel mechanics and EC integrin expression are deregulated. In summary, the proposed interdisciplinary approach will contribute both advanced tools to study cells in vitro and crucial answers for specific questions relating to EC biology.

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The information about "ISPADMEC" are provided by the European Opendata Portal: CORDIS opendata.

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